U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    JAK1 Janus kinase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 677689, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    JAK1provided by VGNC
    Official Full Name
    Janus kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:73810
    See related
    Ensembl:ENSMMUG00000018566
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    JAK-1
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (159362861..159600374)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (64515938..64646471, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S24 pseudogene Neighboring gene 28S ribosomal protein S21, mitochondrial-like Neighboring gene microRNA mir-101-1 Neighboring gene U6 spliceosomal RNA Neighboring gene solute carrier family 2, facilitated glucose transporter member 3 pseudogene Neighboring gene cytochrome c oxidase subunit NDUFA4 pseudogene Neighboring gene ribonucleoprotein, PTB binding 2 Neighboring gene 40S ribosomal protein S26-like Neighboring gene cache domain containing 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Form deprivation modulates retinal neurogenesis in primate experimental myopia. Tkatchenko AV, et al. Proc Natl Acad Sci U S A, 2006 Mar 21. PMID 16537371, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    tyrosine-protein kinase JAK1
    Names
    Janus kinase 1 (a protein tyrosine kinase)
    NP_001244838.1
    XP_028708367.1
    XP_028708401.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257909.1 → NP_001244838.1  tyrosine-protein kinase JAK1

      See identical proteins and their annotated locations for NP_001244838.1

      Status: PROVISIONAL

      Source sequence(s)
      JU322240
      UniProtKB/TrEMBL
      F6YLX1, G7MHH7, H9EUD7
      Related
      ENSMMUP00000024423.3, ENSMMUT00000026100.4
      Conserved Domains (6) summary
      cd05079
      Location:870 → 1153
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd05077
      Location:583 → 846
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 426
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      pfam18377
      Location:147 → 277
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:36 → 129
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:426 → 527
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      159362861..159600374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028852568.1 → XP_028708401.1  tyrosine-protein kinase JAK1 isoform X2

      UniProtKB/TrEMBL
      F6YLX1, G7MHH7, H9EUD7
      Conserved Domains (6) summary
      cd05079
      Location:870 → 1153
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd05077
      Location:583 → 846
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 426
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      pfam18377
      Location:147 → 277
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:36 → 129
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:426 → 527
      SH2; Src homology 2 (SH2) domain

    2. XM_028852534.1 → XP_028708367.1  tyrosine-protein kinase JAK1 isoform X1

      UniProtKB/TrEMBL
      G7MHH7
      Related
      ENSMMUP00000064938.1, ENSMMUT00000090821.1
      Conserved Domains (5) summary
      cd05079
      Location:936 → 1219
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      smart00295
      Location:103 → 352
      B41; Band 4.1 homologues
      cd05077
      Location:649 → 912
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:348 → 492
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      cl15255
      Location:492 → 593
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Miscellaneous