Jak1 Janus kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 16451, updated on 12-Aug-2018

Summary

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Official Symbol: Jak1provided by MGI
Official Full Name: Janus kinase 1provided by MGI
Primary source: MGI:MGI:96628
See related: Ensembl:ENSMUSG00000028530 Vega:OTTMUSG00000008208
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BAP004; AA960307; C130039L05Rik
Expression: Ubiquitous expression in thymus adult (RPKM 28.5), spleen adult (RPKM 26.3) and 28 other tissues See more
Orthologs: human all

Genomic context

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See Jak1 in Genome Data Viewer

Location:: 4 C6; 4 46.19 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	4	NC_000070.6 (101151974..101265291, complement)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	4	NC_000070.5 (100824579..100937887, complement)

Chromosome 4 - NC_000070.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Blockade of JAK1-JAK3 accelerated, and selective inactivation of STAT3 decelerated differentiation of progenitor cells.
Title: Particular Role of JAK/STAT3 Signaling in Functional Control of Mesenchymal Progenitor Cells.
Downregulated SOCS1 expression activates the JAK1/STAT1 pathway and promotes polarization of macrophages into M1 type.
Title: Downregulated SOCS1 expression activates the JAK1/STAT1 pathway and promotes polarization of macrophages into M1 type.
Jak1-deficient hematopoietic stem cells exhibit increased quiescence, an inability to enter the cell cycle in response to hematopoietic stress, and a marked reduction in cytokine sensing, including in response to type I interferons and IL-3.
Title: Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.
In this study, chronic UVB irradiation induced the expression of IL-10 and JAK1 that eventually activates the STAT3 which leads to the transcription of proliferative and antiapoptotic markers.
Title: Caffeic Acid Inhibits Chronic UVB-Induced Cellular Proliferation Through JAK-STAT3 Signaling in Mouse Skin.
findings reveal a mechanism by which JAK1 function and inflammatory signaling may be suppressed in response to metabolic stress and provide a mechanistic rationale for the investigation of AMPK activators in a range of diseases associated with enhanced activation of the JAK-STAT pathway.
Title: Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.
JAK1-mediated signaling cascades in skin regulate the expression of proteases associated with the maintenance of skin barrier function and demonstrate that perturbation of these pathways can lead to the development of spontaneous pruritic dermatitis.
Title: Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis.
Small-scale in vivo screening identified several genes, including Cd109, that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 as a critical, pharmacologically targetable effector of CD109-driven lung cancer metastasis
Title: Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis.
a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.
Title: Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases.
High JAK1 expression is associated with Hepatic Fibrosis.
Title: Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway.
findings demonstrate that clinically relevant doses of the JAK1/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.
Title: Therapeutic effect of JAK1/2 blockade on the manifestations of hemophagocytic lymphohistiocytosis in mice.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Chemically induced (ENU) (2) 1 citation

Pathways from BioSystems

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ARMS-mediated activation, organism-specific biosystem (from REACTOME)
ARMS-mediated activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 interactions, organism-specific biosystem (from REACTOME)
DAP12 interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 signaling, organism-specific biosystem (from REACTOME)
DAP12 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signal transduction, organism-specific biosystem (from REACTOME)
Downstream signal transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Epstein-Barr virus infection, conserved biosystem (from KEGG)
Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
FCERI mediated MAPK activation, organism-specific biosystem (from REACTOME)
FCERI mediated MAPK activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
Fc epsilon receptor (FCERI) signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Frs2-mediated activation, organism-specific biosystem (from REACTOME)
Frs2-mediated activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G beta:gamma signalling through PI3Kgamma, organism-specific biosystem (from REACTOME)
G beta:gamma signalling through PI3Kgamma, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G-protein beta:gamma signalling, organism-specific biosystem (from REACTOME)
G-protein beta:gamma signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
GPVI-mediated activation cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GRB2 events in EGFR signaling, organism-specific biosystem (from REACTOME)
GRB2 events in EGFR signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
Hepatitis C, organism-specific biosystem (from KEGG)
Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
Hepatitis C, conserved biosystem (from KEGG)
Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
IGF1R signaling cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-2 Signaling Pathway, organism-specific biosystemIL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions rela...
IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-5 Signaling Pathway, organism-specific biosystem
IL-5 Signaling Pathway
IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-6 signaling Pathway, organism-specific biosystem
IL-6 signaling Pathway
IL-6-type cytokine receptor ligand interactions, organism-specific biosystem (from REACTOME)
IL-6-type cytokine receptor ligand interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-7 Signaling Pathway, organism-specific biosystem
IL-7 Signaling Pathway
IL-9 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-9 Signaling Pathway, organism-specific biosystem
IL-9 Signaling Pathway
IRS-mediated signalling, organism-specific biosystem (from REACTOME)
IRS-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
IRS-related events triggered by IGF1R, organism-specific biosystemcomputationally inferred pathway (not manually curated)
ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
ISG15 antiviral mechanism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Influenza A, organism-specific biosystem (from KEGG)
Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Influenza A, conserved biosystem (from KEGG)
Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
Insulin receptor signalling cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interferon Signaling, organism-specific biosystem (from REACTOME)
Interferon Signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
Interferon alpha/beta signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interferon gamma signaling, organism-specific biosystem (from REACTOME)
Interferon gamma signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
Interleukin receptor SHC signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-10 signaling, organism-specific biosystem (from REACTOME)
Interleukin-10 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
Interleukin-2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
Interleukin-4 and 13 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-6 family signaling, organism-specific biosystem (from REACTOME)
Interleukin-6 family signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-6 signaling, organism-specific biosystem (from REACTOME)
Interleukin-6 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-7 signaling, organism-specific biosystem (from REACTOME)
Interleukin-7 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
JAK-STAT signaling, organism-specific biosystem (from KEGG)
JAK-STAT signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
JAK-STAT signaling, conserved biosystem (from KEGG)
JAK-STAT signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Leishmaniasis, organism-specific biosystem (from KEGG)
Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
Leishmaniasis, conserved biosystem (from KEGG)
Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
MAPK family signaling cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MAPK1 (ERK2) activation, organism-specific biosystem (from REACTOME)
MAPK1 (ERK2) activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MAPK1/MAPK3 signaling, organism-specific biosystem (from REACTOME)
MAPK1/MAPK3 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MAPK3 (ERK1) activation, organism-specific biosystem (from REACTOME)
MAPK3 (ERK1) activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Measles, organism-specific biosystem (from KEGG)
Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Measles, conserved biosystem (from KEGG)
Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
NCAM signaling for neurite out-growth, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
Osteoclast differentiation, organism-specific biosystem (from KEGG)
Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Osteoclast differentiation, conserved biosystem (from KEGG)
Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Pancreatic cancer, organism-specific biosystem (from KEGG)
Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
Pancreatic cancer, conserved biosystem (from KEGG)
Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PluriNetWork, organism-specific biosystem (from WikiPathways)
PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
Prolonged ERK activation events, organism-specific biosystem (from REACTOME)
Prolonged ERK activation events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RAF-independent MAPK1/3 activation, organism-specific biosystem (from REACTOME)
RAF-independent MAPK1/3 activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RAF/MAP kinase cascade, organism-specific biosystem (from REACTOME)
RAF/MAP kinase cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RET signaling, organism-specific biosystem (from REACTOME)
RET signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of IFNA signaling, organism-specific biosystem (from REACTOME)
Regulation of IFNA signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of IFNG signaling, organism-specific biosystem (from REACTOME)
Regulation of IFNG signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SHC1 events in EGFR signaling, organism-specific biosystem (from REACTOME)
SHC1 events in EGFR signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SOS-mediated signalling, organism-specific biosystem (from REACTOME)
SOS-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
Signaling by Insulin receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Leptin, organism-specific biosystem (from REACTOME)
Signaling by Leptin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
Signaling by SCF-KIT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by VEGF, organism-specific biosystem (from REACTOME)
Signaling by VEGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling to ERKs, organism-specific biosystem (from REACTOME)
Signalling to ERKs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling to RAS, organism-specific biosystem (from REACTOME)
Signalling to RAS, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
Signalling to p38 via RIT and RIN, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
Th17 cell differentiation, organism-specific biosystem (from KEGG)
Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
Th17 cell differentiation, conserved biosystem (from KEGG)
Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
Toxoplasmosis, organism-specific biosystem (from KEGG)
Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Toxoplasmosis, conserved biosystem (from KEGG)
Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...
VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
VEGFA-VEGFR2 Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
VEGFR2 mediated cell proliferation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Jak1 (e-PCR), detects polymorphism
- UniSTS:143638

AA960307 (e-PCR)
- UniSTS:159262

D4Mit305 (e-PCR), detects polymorphism
- UniSTS:130097

40.MMHAP29FLF4.seq (e-PCR)
- UniSTS:124364

Homology

Homologs of the Jak1 gene: The Jak1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 232 organisms have orthologs with human gene Jak1
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
CCR5 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
growth hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
growth hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
growth hormone receptor binding	ISO Inferred from Sequence Orthology more info
kinase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	IEA Inferred from Electronic Annotation more info
protein phosphatase binding	ISO Inferred from Sequence Orthology more info
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
transferase activity	IEA Inferred from Electronic Annotation more info
ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
cellular response to interleukin-3	IDA Inferred from Direct Assay more info	PubMed
cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
enzyme linked receptor protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
interleukin-2-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of STAT cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
protein phosphorylation	IEA Inferred from Electronic Annotation more info
response to antibiotic	ISO Inferred from Sequence Orthology more info	PubMed
tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase JAK1

Names: JAK-1

NP_666257.2

EC 2.7.10.2

XP_006502875.1

EC 2.7.10.2

XP_011238753.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146145.2 → NP_666257.2 tyrosine-protein kinase JAK1

See identical proteins and their annotated locations for NP_666257.2

Status: VALIDATED

Source sequence(s)

AK141210, AK152128, AL627251, AL645668

Consensus CDS

CCDS18393.1

UniProtKB/TrEMBL

B1ASP2, Q3U8P8, Q3URU8

Related

ENSMUSP00000099842.3, OTTMUSP00000008566, ENSMUST00000102781.9, OTTMUST00000018649

Conserved Domains (6) summary

cd05079
Location:869 → 1152

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd10378
Location:426 → 526

SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:582 → 845

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:874 → 1146

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

NC_000070.6 Reference GRCm38.p4 C57BL/6J

Range

101151974..101265291 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502812.3 → XP_006502875.1 tyrosine-protein kinase JAK1 isoform X1

See identical proteins and their annotated locations for XP_006502875.1

UniProtKB/TrEMBL

B1ASP2

Conserved Domains (6) summary

cd05079
Location:869 → 1152

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd10378
Location:426 → 526

SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:582 → 845

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:874 → 1146

Pkinase_Tyr; Protein tyrosine kinase
XM_011240451.2 → XP_011238753.1 tyrosine-protein kinase JAK1 isoform X1

See identical proteins and their annotated locations for XP_011238753.1

UniProtKB/TrEMBL

B1ASP2

Conserved Domains (6) summary

cd05079
Location:869 → 1152

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd10378
Location:426 → 526

SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:582 → 845

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:874 → 1146

Pkinase_Tyr; Protein tyrosine kinase