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Jak1 Janus kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 16451, updated on 18-Apr-2024

Summary

Official Symbol
Jak1provided by MGI
Official Full Name
Janus kinase 1provided by MGI
Primary source
MGI:MGI:96628
See related
Ensembl:ENSMUSG00000028530 AllianceGenome:MGI:96628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BAP004; C130039L05Rik
Summary
Enables growth hormone receptor binding activity and protein tyrosine kinase activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to cytokine stimulus; and positive regulation of receptor signaling pathway via STAT. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; colorectal cancer; hepatocellular carcinoma; ovarian cancer; and pancreatic adenocarcinoma. Orthologous to human JAK1 (Janus kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 28.5), spleen adult (RPKM 26.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
4 C6; 4 46.19 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101009171..101122493, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (101151974..101265282, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10895 Neighboring gene predicted gene, 35956 Neighboring gene ribonucleoprotein, PTB-binding 2 Neighboring gene predicted gene, 22100 Neighboring gene STARR-positive B cell enhancer ABC_E6194 Neighboring gene predicted gene, 24468 Neighboring gene proteasome (prosome, macropain) subunit, beta type 2 pseudogene Neighboring gene predicted gene, 52754 Neighboring gene STARR-seq mESC enhancer starr_10896 Neighboring gene predicted gene, 25124 Neighboring gene STARR-positive B cell enhancer mm9_chr4:100965565-100965866 Neighboring gene predicted gene 12796

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC37919

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables CCR5 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables growth hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell surface receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell surface receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to interleukin-3 IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to interleukin-7 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in interleukin-11-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-15-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-2-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-4-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-9-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of homotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of receptor signaling pathway via STAT IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to antibiotic ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in type II interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein kinase JAK1
Names
JAK-1
NP_038595.1
NP_666257.2
XP_006502875.1
XP_030109122.1
XP_030109123.1
XP_030109125.1
XP_036019634.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013567.1NP_038595.1  tyrosine-protein kinase JAK1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627251, AL645668
    UniProtKB/TrEMBL
    Q3URU8
    Conserved Domains (5) summary
    cd05079
    Location:7681051
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    smart00295
    Location:37286
    B41; Band 4.1 homologues
    cd13332
    Location:282426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    cl21453
    Location:582750
    PKc_like; Protein Kinases, catalytic domain
  2. NM_146145.2NP_666257.2  tyrosine-protein kinase JAK1 isoform 1

    See identical proteins and their annotated locations for NP_666257.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK141210, AK152128, AL627251, AL645668
    Consensus CDS
    CCDS18393.1
    UniProtKB/TrEMBL
    B1ASP2, Q3URU8
    Related
    ENSMUSP00000099842.4, ENSMUST00000102781.10
    Conserved Domains (6) summary
    cd05079
    Location:8691152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    cd05077
    Location:582845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam18377
    Location:147277
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:52129
    FERM_F1; FERM F1 ubiquitin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    101009171..101122493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253263.2XP_030109123.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    B1ASP2, Q3URU8
    Conserved Domains (6) summary
    cd05079
    Location:8691152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    cd05077
    Location:582845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam18377
    Location:147277
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:52129
    FERM_F1; FERM F1 ubiquitin-like domain
  2. XM_036163741.1XP_036019634.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    B1ASP2, Q3URU8
    Conserved Domains (6) summary
    cd05079
    Location:8691152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    cd05077
    Location:582845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam18377
    Location:147277
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:52129
    FERM_F1; FERM F1 ubiquitin-like domain
  3. XM_030253265.2XP_030109125.1  tyrosine-protein kinase JAK1 isoform X2

    UniProtKB/TrEMBL
    Q8K0I7
    Conserved Domains (3) summary
    cd05079
    Location:473756
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd05077
    Location:186449
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cl15255
    Location:50130
    SH2; Src homology 2 (SH2) domain
  4. XM_006502812.5XP_006502875.1  tyrosine-protein kinase JAK1 isoform X1

    See identical proteins and their annotated locations for XP_006502875.1

    UniProtKB/TrEMBL
    B1ASP2, Q3URU8
    Conserved Domains (6) summary
    cd05079
    Location:8691152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    cd05077
    Location:582845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam18377
    Location:147277
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:52129
    FERM_F1; FERM F1 ubiquitin-like domain
  5. XM_030253262.2XP_030109122.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    B1ASP2, Q3URU8
    Conserved Domains (6) summary
    cd05079
    Location:8691152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    cd05077
    Location:582845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
    pfam18377
    Location:147277
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:52129
    FERM_F1; FERM F1 ubiquitin-like domain