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    RBM15 RNA binding motif protein 15 [ Homo sapiens (human) ]

    Gene ID: 64783, updated on 17-Jun-2024

    Summary

    Official Symbol
    RBM15provided by HGNC
    Official Full Name
    RNA binding motif protein 15provided by HGNC
    Primary source
    HGNC:HGNC:14959
    See related
    Ensembl:ENSG00000162775 MIM:606077; AllianceGenome:HGNC:14959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OTT; OTT1; SPEN
    Summary
    Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
    Expression
    Broad expression in bone marrow (RPKM 6.3), testis (RPKM 2.8) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RBM15 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (110339377..110346677)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (110354432..110361733)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110881999..110889299)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily C member 4 Neighboring gene uncharacterized LOC124900436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1466 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:110837163-110837321 Neighboring gene RBM15 antisense RNA 1 Neighboring gene uncharacterized LOC124904276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:110882428-110883166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110883828-110884393 Neighboring gene solute carrier family 16 member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1471 Neighboring gene LAMTOR5 and SLC16A4 antisense RNA 1 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag NXF1 upregulates the RBM15-mediated Gag expression from pNLgag-RTE, suggesting cooperation between RBM15 and NXF1 PubMed
    Rev rev HIV-1 Rev interacting protein, RNA binding motif protein 15 (RBM15), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with RBM15 is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12479, FLJ21943, MGC119584

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    RNA-binding protein 15
    Names
    one twenty two protein
    one twenty-two
    one-twenty two protein 1
    putative RNA-binding protein 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201545.2NP_001188474.1  RNA-binding protein 15 isoform 2

      See identical proteins and their annotated locations for NP_001188474.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI863760, AL355488, BC006397, BC098140
      Consensus CDS
      CCDS59198.1
      UniProtKB/TrEMBL
      A0A499FJY3
      Related
      ENSP00000473552.3, ENST00000487146.8
      Conserved Domains (5) summary
      TIGR01622
      Location:624736
      SF-CC1; splicing factor, CC1-like family
      pfam07744
      Location:781954
      SPOC; SPOC domain
      cd12553
      Location:169251
      RRM1_RBM15; RNA recognition motif 1 (RRM1) found in vertebrate RNA binding motif protein 15 (RBM15)
      cd12555
      Location:367453
      RRM2_RBM15; RNA recognition motif 2 (RRM2) found in vertebrate RNA binding motif protein 15 (RBM15)
      cd12557
      Location:456528
      RRM3_RBM15; RNA recognition motif 3 (RRM3) found in vertebrate RNA binding motif protein 15 (RBM15)
    2. NM_022768.5NP_073605.4  RNA-binding protein 15 isoform 1

      See identical proteins and their annotated locations for NP_073605.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AL355488, BC042587, BC047479, BC062316
      Consensus CDS
      CCDS822.1
      UniProtKB/Swiss-Prot
      A1A693, Q3ZB86, Q4V760, Q5D058, Q5T613, Q86VW9, Q96PE4, Q96SC9, Q96SD0, Q96T37, Q96T38, Q9BRA5, Q9H6R8, Q9H9Y0
      UniProtKB/TrEMBL
      A0A087WWP4
      Related
      ENSP00000358799.3, ENST00000369784.9
      Conserved Domains (5) summary
      TIGR01622
      Location:624736
      SF-CC1; splicing factor, CC1-like family
      pfam07744
      Location:781954
      SPOC; SPOC domain
      cd12553
      Location:169251
      RRM1_RBM15; RNA recognition motif 1 (RRM1) found in vertebrate RNA binding motif protein 15 (RBM15)
      cd12555
      Location:367453
      RRM2_RBM15; RNA recognition motif 2 (RRM2) found in vertebrate RNA binding motif protein 15 (RBM15)
      cd12557
      Location:456528
      RRM3_RBM15; RNA recognition motif 3 (RRM3) found in vertebrate RNA binding motif protein 15 (RBM15)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      110339377..110346677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      110354432..110361733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014092.1: Suppressed sequence

      Description
      NM_014092.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.