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Rbm15 RNA binding motif protein 15 [ Mus musculus (house mouse) ]

Gene ID: 229700, updated on 12-May-2024

Summary

Official Symbol
Rbm15provided by MGI
Official Full Name
RNA binding motif protein 15provided by MGI
Primary source
MGI:MGI:2443205
See related
Ensembl:ENSMUSG00000048109 AllianceGenome:MGI:2443205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1438; C230088J01Rik
Summary
Enables RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and thrombopoietin-mediated signaling pathway. Acts upstream of or within several processes, including circulatory system development; regulation of transcription by RNA polymerase II; and spleen development. Located in nucleus. Is expressed in several structures, including brain; olfactory epithelium; retina; thymus; and trophectoderm. Orthologous to human RBM15 (RNA binding motif protein 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 2.5), limb E14.5 (RPKM 1.9) and 28 other tissues See more
Orthologs
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Genomic context

See Rbm15 in Genome Data Viewer
Location:
3 F2.3; 3 46.83 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107212827..107244102, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107305511..107334460, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A630076J17 gene Neighboring gene STARR-positive B cell enhancer ABC_E6103 Neighboring gene prokineticin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:107081789-107082089 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:107136515-107136698 Neighboring gene STARR-seq mESC enhancer starr_08664 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide pseudogene Neighboring gene predicted gene, 35700

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (5)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1438

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dosage compensation by inactivation of X chromosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of myeloid cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within placenta blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription of Notch receptor target IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thrombopoietin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein 15
Names
one-twenty two protein 1
putative RNA-binding protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045807.2NP_001039272.1  RNA-binding protein 15

    See identical proteins and their annotated locations for NP_001039272.1

    Status: VALIDATED

    Source sequence(s)
    AC132405
    Consensus CDS
    CCDS38590.1
    UniProtKB/Swiss-Prot
    A0PJG5, Q0VBL3, Q3THK4, Q3TLX0, Q571M7, Q66JP8, Q6PGG1, Q7TT82
    Related
    ENSMUSP00000054424.10, ENSMUST00000061772.11
    Conserved Domains (5) summary
    cd12553
    Location:168250
    RRM1_RBM15; RNA recognition motif 1 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12555
    Location:366452
    RRM2_RBM15; RNA recognition motif 2 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12557
    Location:455527
    RRM3_RBM15; RNA recognition motif 3 in vertebrate RNA binding motif protein 15 (RBM15)
    pfam07744
    Location:781955
    SPOC; SPOC domain
    cl25887
    Location:623751
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    107212827..107244102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003954318.2 RNA Sequence

  2. XR_003954319.2 RNA Sequence

  3. XR_001783686.3 RNA Sequence

  4. XR_003954317.2 RNA Sequence