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    Park7 Parkinson disease (autosomal recessive, early onset) 7 [ Mus musculus (house mouse) ]

    Gene ID: 57320, updated on 12-Sep-2021

    Summary

    Official Symbol
    Park7provided by MGI
    Official Full Name
    Parkinson disease (autosomal recessive, early onset) 7provided by MGI
    Primary source
    MGI:MGI:2135637
    See related
    Ensembl:ENSMUSG00000028964
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dj1; DJ-1
    Expression
    Ubiquitous expression in kidney adult (RPKM 117.4), CNS E11.5 (RPKM 109.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Park7 in Genome Data Viewer
    Location:
    4; 4 E2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (150981590..150994378, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150897133..150909921, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (150271242..150284030, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700045H11 gene Neighboring gene ribosomal protein S15A, pseudogene 3 Neighboring gene ERBB receptor feedback inhibitor 1 Neighboring gene tumor necrosis factor receptor superfamily, member 9 Neighboring gene predicted gene, 23405

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-dopa decarboxylase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cupric ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cuprous ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glyoxalase (glycolic acid-forming) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mercury ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity, acting on peroxide as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxygen sensor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peroxiredoxin activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein deglycase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small protein activating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables superoxide dismutase copper chaperone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tyrosine 3-monooxygenase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like protein conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular detoxification of aldehyde ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular detoxification of methylglyoxal ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glyoxal IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to glyoxal ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detection of oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detoxification of copper ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detoxification of copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detoxification of mercury ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detoxification of mercury ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dopamine uptake involved in synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glutathione deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycolate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycolate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glyoxal metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glyoxal metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in guanine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in guanine deglycation, glyoxal removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in guanine deglycation, glyoxal removal ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in guanine deglycation, methylglyoxal removal ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone modification ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hydrogen peroxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hydrogen peroxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lactate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within membrane hyperpolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in methylglyoxal catabolic process to lactate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of NMDA glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TRAIL-activated apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hydrogen peroxide-induced cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hydrogen peroxide-induced neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hydrogen peroxide-induced neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidative stress-induced cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidative stress-induced neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of reactive oxygen species biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ubiquitin-protein transferase activity IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-arginine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-cysteine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of L-dopa biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of L-dopa decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NAD(P)H oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of acute inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of androgen receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fertilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial electron transport, NADH to ubiquinone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of oxidative phosphorylation uncoupler activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of pyrroline-5-carboxylate reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of reactive oxygen species biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of superoxide dismutase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine 3-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deglycation, glyoxal removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein deglycation, glyoxal removal ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of histone ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm head ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    Parkinson disease protein 7 homolog
    Names
    RNA-binding protein regulatory subunit
    maillard deglycase
    parkinson disease protein 7 homolog
    parkinsonism-associated deglycase
    protein DJ-1
    protein deglycase DJ-1
    protein/nucleic acid deglycase DJ-1
    NP_065594.2
    XP_036020176.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020569.3NP_065594.2  Parkinson disease protein 7 homolog

      See identical proteins and their annotated locations for NP_065594.2

      Status: VALIDATED

      Source sequence(s)
      AB015652, CA456587, CD776363
      Consensus CDS
      CCDS18975.1
      UniProtKB/Swiss-Prot
      Q99LX0
      Related
      ENSMUSP00000030805.8, ENSMUST00000030805.14
      Conserved Domains (2) summary
      cd03135
      Location:6172
      GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
      TIGR01383
      Location:5184
      not_thiJ; DJ-1 family protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      150981590..150994378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164283.1XP_036020176.1  Parkinson disease protein 7 homolog isoform X1

      Conserved Domains (1) summary
      cl00020
      Location:51128
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
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