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    Park7 Parkinson disease (autosomal recessive, early onset) 7 [ Mus musculus (house mouse) ]

    Gene ID: 57320, updated on 9-Dec-2024

    Summary

    Official Symbol
    Park7provided by MGI
    Official Full Name
    Parkinson disease (autosomal recessive, early onset) 7provided by MGI
    Primary source
    MGI:MGI:2135637
    See related
    Ensembl:ENSMUSG00000028964 AllianceGenome:MGI:2135637
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dj1; DJ-1
    Summary
    Enables oxygen sensor activity and peroxiredoxin activity. Involved in several processes, including detoxification of inorganic compound; negative regulation of intrinsic apoptotic signaling pathway; and negative regulation of protein metabolic process. Acts upstream of or within several processes, including dopamine uptake involved in synaptic transmission; membrane hyperpolarization; and positive regulation of reactive oxygen species biosynthetic process. Located in several cellular components, including cell body; endoplasmic reticulum; and mitochondrion. Is active in synaptic vesicle. Is expressed in central nervous system and retina. Used to study Parkinson's disease 7. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 117.4), CNS E11.5 (RPKM 109.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Park7 in Genome Data Viewer
    Location:
    4 E2; 4 81.52 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (150981590..150994378, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150897133..150909921, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700045H11 gene Neighboring gene ribosomal protein S15A, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E10293 Neighboring gene ERBB receptor feedback inhibitor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:150271076-150271277 Neighboring gene STARR-seq mESC enhancer starr_12178 Neighboring gene STARR-positive B cell enhancer ABC_E2733 Neighboring gene tumor necrosis factor receptor superfamily, member 9 Neighboring gene predicted gene, 23405

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-dopa decarboxylase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-dopa decarboxylase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables copper ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cupric ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cupric ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cuprous ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cuprous ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glyoxalase (glycolic acid-forming) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glyoxalase (glycolic acid-forming) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mercury ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mercury ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nuclear androgen receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity, acting on peroxide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxidoreductase activity, acting on peroxide as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxygen sensor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxiredoxin activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein deglycase activity ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables protein deglycase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein deglycase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small protein activating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small protein activating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables superoxide dismutase copper chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables superoxide dismutase copper chaperone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tyrosine 3-monooxygenase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tyrosine 3-monooxygenase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like protein conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-like protein conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables ubiquitin-specific protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in androgen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular detoxification of aldehyde ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular detoxification of aldehyde ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular detoxification of methylglyoxal ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular detoxification of methylglyoxal ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to glyoxal IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to glyoxal ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detection of oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detoxification of copper ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detoxification of copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detoxification of copper ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in detoxification of hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detoxification of hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detoxification of mercury ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detoxification of mercury ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dopamine uptake involved in synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycolate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycolate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycolate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glyoxal catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glyoxal metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glyoxal metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glyoxal metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in guanine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in guanine deglycation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in guanine deglycation, glyoxal removal ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in guanine deglycation, glyoxal removal ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in guanine deglycation, methylglyoxal removal ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in guanine deglycation, methylglyoxal removal ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within hydrogen peroxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hydrogen peroxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lactate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within membrane hyperpolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in methylglyoxal catabolic process to lactate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in methylglyoxal catabolic process to lactate ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in methylglyoxal metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in methylglyoxal metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of TRAIL-activated apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of TRAIL-activated apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of death-inducing signaling complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein K48-linked deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of reactive oxygen species biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-arginine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-cysteine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of L-dopa biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of L-dopa biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of L-dopa decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NAD(P)H oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of acute inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of androgen receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dopamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fertilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-8 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial electron transport, NADH to ubiquinone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of oxidative phosphorylation uncoupler activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of pyrroline-5-carboxylate reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of reactive oxygen species biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of superoxide dismutase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine 3-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deglycation, glyoxal removal ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deglycation, methylglyoxal removal ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deglycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of androgen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm head ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    Parkinson disease protein 7 homolog
    Names
    RNA-binding protein regulatory subunit
    maillard deglycase
    parkinson disease protein 7 homolog
    parkinsonism-associated deglycase
    protein DJ-1
    protein deglycase DJ-1
    protein/nucleic acid deglycase DJ-1
    NP_065594.2
    XP_036020176.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020569.3NP_065594.2  Parkinson disease protein 7 homolog

      See identical proteins and their annotated locations for NP_065594.2

      Status: VALIDATED

      Source sequence(s)
      AB015652, CA456587, CD776363
      Consensus CDS
      CCDS18975.1
      UniProtKB/Swiss-Prot
      O88306, Q3THB9, Q3U509, Q99LX0
      UniProtKB/TrEMBL
      A2A813
      Related
      ENSMUSP00000030805.8, ENSMUST00000030805.14
      Conserved Domains (1) summary
      TIGR01383
      Location:5184
      not_thiJ; DJ-1 family protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      150981590..150994378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164283.1XP_036020176.1  Parkinson disease protein 7 homolog isoform X1

      Conserved Domains (1) summary
      cl00020
      Location:51128
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain