U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    SLC39A10 solute carrier family 39 member 10 [ Homo sapiens (human) ]

    Gene ID: 57181, updated on 17-Jun-2024

    Summary

    Official Symbol
    SLC39A10provided by HGNC
    Official Full Name
    solute carrier family 39 member 10provided by HGNC
    Primary source
    HGNC:HGNC:20861
    See related
    Ensembl:ENSG00000196950 MIM:608733; AllianceGenome:HGNC:20861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZIP10; LZT-Hs2
    Summary
    Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in thyroid (RPKM 12.9), brain (RPKM 12.5) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC39A10 in Genome Data Viewer
    Location:
    2q32.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (195613029..195737700)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (196097362..196222040)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (196521682..196602424)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:196434945-196435535 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:196450653-196451242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:196452793-196453292 Neighboring gene long intergenic non-protein coding RNA 1827 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:196477499-196478360 Neighboring gene adenosylhomocysteinase pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16889 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12199 Neighboring gene RNA, U6 small nuclear 915, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:196559503-196560702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:196569194-196569694 Neighboring gene uncharacterized LOC107985972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:196608945-196609445 Neighboring gene dynein axonemal heavy chain 7 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:196652546-196653745 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:196722945-196724144 Neighboring gene E2F transcription factor 3 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC39A10 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of solute carrier family 39 (zinc transporter), member 10 (SLC39A10) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ31108, MGC126565, MGC138428, DKFZp781L10106

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monoatomic cation:bicarbonate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular monoatomic cation homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular zinc ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of B cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in zinc ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in zinc ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc transporter ZIP10
    Names
    ZIP-10
    ZRT/IRT-like protein 10
    solute carrier family 39 (metal ion transporter), member 10
    solute carrier family 39 (zinc transporter), member 10
    zinc transporter 10
    zrt- and Irt-like protein 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127257.2NP_001120729.1  zinc transporter ZIP10 precursor

      See identical proteins and their annotated locations for NP_001120729.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC013274, AI693720, CR749813
      Consensus CDS
      CCDS33353.1
      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
      Related
      ENSP00000386766.3, ENST00000409086.7
      Conserved Domains (1) summary
      pfam02535
      Location:404819
      Zip; ZIP Zinc transporter
    2. NM_020342.3NP_065075.1  zinc transporter ZIP10 precursor

      See identical proteins and their annotated locations for NP_065075.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC013274, AI693720, AK291241
      Consensus CDS
      CCDS33353.1
      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
      Related
      ENSP00000352655.5, ENST00000359634.10
      Conserved Domains (1) summary
      pfam02535
      Location:404819
      Zip; ZIP Zinc transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      195613029..195737700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511504.3XP_011509806.1  zinc transporter ZIP10 isoform X4

      See identical proteins and their annotated locations for XP_011509806.1

      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
      Conserved Domains (1) summary
      pfam02535
      Location:404819
      Zip; ZIP Zinc transporter
    2. XM_005246689.5XP_005246746.3  zinc transporter ZIP10 isoform X1

    3. XM_047445143.1XP_047301099.1  zinc transporter ZIP10 isoform X4

      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
    4. XM_011511507.3XP_011509809.2  zinc transporter ZIP10 isoform X5

    5. XM_017004523.2XP_016860012.2  zinc transporter ZIP10 isoform X6

    6. XM_047445144.1XP_047301100.1  zinc transporter ZIP10 isoform X4

      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
    7. XM_047445141.1XP_047301097.1  zinc transporter ZIP10 isoform X2

    8. XM_047445142.1XP_047301098.1  zinc transporter ZIP10 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      196097362..196222040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343084.1XP_054199059.1  zinc transporter ZIP10 isoform X4

      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
    2. XM_054343085.1XP_054199060.1  zinc transporter ZIP10 isoform X4

      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
    3. XM_054343081.1XP_054199056.1  zinc transporter ZIP10 isoform X7

    4. XM_054343087.1XP_054199062.1  zinc transporter ZIP10 isoform X8

    5. XM_054343088.1XP_054199063.1  zinc transporter ZIP10 isoform X9

    6. XM_054343086.1XP_054199061.1  zinc transporter ZIP10 isoform X4

      UniProtKB/Swiss-Prot
      A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
    7. XM_054343082.1XP_054199057.1  zinc transporter ZIP10 isoform X2

    8. XM_054343083.1XP_054199058.1  zinc transporter ZIP10 isoform X3