Slc39a10 solute carrier family 39 (zinc transporter), member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc39a10provided by MGI
Official Full Name: solute carrier family 39 (zinc transporter), member 10provided by MGI
Primary source: MGI:MGI:1914515
See related: Ensembl:ENSMUSG00000025986 AllianceGenome:MGI:1914515
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zip10; mKIAA1265; 5430433I10; 2900042E17Rik
Summary: Enables zinc ion transmembrane transporter activity. Acts upstream of or within several processes, including positive regulation of B cell proliferation; positive regulation of B cell receptor signaling pathway; and positive regulation of protein tyrosine phosphatase activity. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; ovary; sensory organ; and urinary system. Orthologous to human SLC39A10 (solute carrier family 39 member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 17.1), frontal lobe adult (RPKM 14.5) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 C1.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (46846704..46964952, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (46807544..46925776, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PrP and ZIP6 inherited the ability to interact with NCAM1 from their common ZIP ancestors but have since diverged to control distinct posttranslational modifications of NCAM1.
Title: A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.
The results indicate that ZIP10 plays important roles in epidermal development via, at least in part, the ZIP10-zinc-p63 signaling axis, thereby highlighting the physiological significance of zinc regulation in the maintenance of skin epidermis.
Title: Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis.
Zip10-deficiency in mature B cells attenuated both T-cell-dependent and -independent immune responses in vivo. The Zip10-deficient mature B cells proliferated poorly in response to BCR cross-linking, as a result of dysregulated BCR signaling.
Title: Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength.
Genetic ablation of Zip10 in early B-cell stages resulted in significant reductions in B-cell populations, and the inducible deletion of Zip10 in pro-B cells increased the caspase activity in parallel with a decrease in intracellular Zn levels.
Title: Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development.
Results reveal a novel repressive role for MTF-1 in the regulation of the Zip10 zinc transporter expression by pausing Pol II transcription.
Title: MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction.
mice fed low-Zn diet had reduced number of terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells compromised seminiferous tubule structure, and reduced Zip10 and Zip6 abundance (>50%; P < 0.5) compared with control diet
Title: Moderate zinc deficiency reduces testicular Zip6 and Zip10 abundance and impairs spermatogenesis in mice.
The expression of Slc30a1, Slc39a8, and Slc39a10 in the erythrocytes of zinc deficient and replete mice is reported.
Title: Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc39a10 (e-PCR), detects polymorphism
- UniSTS:547343

RH143016 (e-PCR)
- UniSTS:232263

Slc39a10 (e-PCR), detects polymorphism
- UniSTS:526926

NoName (e-PCR)
- UniSTS:234124

Homology

Homologs of the Slc39a10 gene: The Slc39a10 gene is conserved in human, chimpanzee, Rhesus monkey, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 488 organisms have orthologs with human gene Slc39a10
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables monoatomic cation:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in intracellular monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of B cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within positive regulation of B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein tyrosine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within zinc ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within zinc ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc transporter ZIP10

Names: ZIP-10; solute carrier family 39 member 10; zrt- and Irt-like protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356416.1 → NP_001343345.1 zinc transporter ZIP10 precursor

Status: VALIDATED

Source sequence(s)

AC116452, AC124185

Consensus CDS

CCDS14936.1

UniProtKB/Swiss-Prot

Q8C0L2

Conserved Domains (1) summary

pfam02535
Location:406 → 821

Zip; ZIP Zinc transporter
NM_001356417.1 → NP_001343346.1 zinc transporter ZIP10 precursor

Status: VALIDATED

Source sequence(s)

AC109276, AC116452, AC124185

Consensus CDS

CCDS14936.1

UniProtKB/Swiss-Prot

Q8C0L2

Conserved Domains (1) summary

pfam02535
Location:406 → 821

Zip; ZIP Zinc transporter
NM_172653.3 → NP_766241.2 zinc transporter ZIP10 precursor

See identical proteins and their annotated locations for NP_766241.2

Status: VALIDATED

Source sequence(s)

AC116452, AC124185

Consensus CDS

CCDS14936.1

UniProtKB/Swiss-Prot

Q6P5F6, Q8C0L2

Related

ENSMUSP00000027131.5, ENSMUST00000027131.6

Conserved Domains (1) summary

pfam02535
Location:406 → 821

Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

46846704..46964952 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164377.1 → XP_036020270.1 zinc transporter ZIP10 isoform X2

UniProtKB/Swiss-Prot

Q8C0L2

Conserved Domains (1) summary

pfam02535
Location:406 → 821

Zip; ZIP Zinc transporter
XM_006495932.3 → XP_006495995.1 zinc transporter ZIP10 isoform X1

Conserved Domains (1) summary

pfam02535
Location:416 → 831

Zip; ZIP Zinc transporter
XM_006495933.5 → XP_006495996.1 zinc transporter ZIP10 isoform X2

See identical proteins and their annotated locations for XP_006495996.1

UniProtKB/Swiss-Prot

Q6P5F6, Q8C0L2

Conserved Domains (1) summary

pfam02535
Location:406 → 821

Zip; ZIP Zinc transporter