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SLC39A10 solute carrier family 39 member 10 [ Homo sapiens (human) ]

Gene ID: 57181, updated on 24-Nov-2020

Summary

Official Symbol
SLC39A10provided by HGNC
Official Full Name
solute carrier family 39 member 10provided by HGNC
Primary source
HGNC:HGNC:20861
See related
Ensembl:ENSG00000196950 MIM:608733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LZT-Hs2
Summary
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in thyroid (RPKM 12.9), brain (RPKM 12.5) and 21 other tissues See more
Orthologs

Genomic context

See SLC39A10 in Genome Data Viewer
Location:
2q32.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (195575944..195737701)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (196477798..196602426)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376755 Neighboring gene RNA, U6 small nuclear 169, pseudogene Neighboring gene long intergenic non-protein coding RNA 1827 Neighboring gene adenosylhomocysteinase pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 4685 Neighboring gene RNA, U6 small nuclear 915, pseudogene Neighboring gene uncharacterized LOC107985972 Neighboring gene uncharacterized LOC105373819 Neighboring gene dynein axonemal heavy chain 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC39A10 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of solute carrier family 39 (zinc transporter), member 10 (SLC39A10) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31108, MGC126565, MGC138428, DKFZp781L10106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc transporter ZIP10
Names
ZIP-10
solute carrier family 39 (metal ion transporter), member 10
solute carrier family 39 (zinc transporter), member 10
zrt- and Irt-like protein 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127257.2NP_001120729.1  zinc transporter ZIP10 precursor

    See identical proteins and their annotated locations for NP_001120729.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC013274, AI693720, CR749813
    Consensus CDS
    CCDS33353.1
    UniProtKB/Swiss-Prot
    Q9ULF5
    UniProtKB/TrEMBL
    A0A024R3W5, Q05C42
    Related
    ENSP00000386766.3, ENST00000409086.7
    Conserved Domains (1) summary
    pfam02535
    Location:404819
    Zip; ZIP Zinc transporter
  2. NM_020342.3NP_065075.1  zinc transporter ZIP10 precursor

    See identical proteins and their annotated locations for NP_065075.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC013274, AI693720, AK291241
    Consensus CDS
    CCDS33353.1
    UniProtKB/Swiss-Prot
    Q9ULF5
    UniProtKB/TrEMBL
    A0A024R3W5
    Related
    ENSP00000352655.5, ENST00000359634.10
    Conserved Domains (1) summary
    pfam02535
    Location:404819
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    195575944..195737701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511505.3XP_011509807.1  zinc transporter ZIP10 isoform X1

    See identical proteins and their annotated locations for XP_011509807.1

    UniProtKB/Swiss-Prot
    Q9ULF5
    UniProtKB/TrEMBL
    A0A024R3W5
    Conserved Domains (1) summary
    pfam02535
    Location:404819
    Zip; ZIP Zinc transporter
  2. XM_011511504.2XP_011509806.1  zinc transporter ZIP10 isoform X1

    See identical proteins and their annotated locations for XP_011509806.1

    UniProtKB/Swiss-Prot
    Q9ULF5
    UniProtKB/TrEMBL
    A0A024R3W5
    Conserved Domains (1) summary
    pfam02535
    Location:404819
    Zip; ZIP Zinc transporter
  3. XM_017004522.2XP_016860011.1  zinc transporter ZIP10 isoform X2

    Conserved Domains (1) summary
    pfam02535
    Location:404716
    Zip; ZIP Zinc transporter
  4. XM_005246689.4XP_005246746.2  zinc transporter ZIP10 isoform X1

    See identical proteins and their annotated locations for XP_005246746.2

    UniProtKB/Swiss-Prot
    Q9ULF5
    UniProtKB/TrEMBL
    A0A024R3W5
    Conserved Domains (1) summary
    pfam02535
    Location:404819
    Zip; ZIP Zinc transporter
  5. XM_011511507.2XP_011509809.1  zinc transporter ZIP10 isoform X2

    Conserved Domains (1) summary
    pfam02535
    Location:404716
    Zip; ZIP Zinc transporter
  6. XM_017004523.1XP_016860012.1  zinc transporter ZIP10 isoform X3

  7. XM_011511506.3XP_011509808.1  zinc transporter ZIP10 isoform X1

    See identical proteins and their annotated locations for XP_011509808.1

    UniProtKB/Swiss-Prot
    Q9ULF5
    UniProtKB/TrEMBL
    A0A024R3W5
    Conserved Domains (1) summary
    pfam02535
    Location:404819
    Zip; ZIP Zinc transporter
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