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SLC39A10 solute carrier family 39 member 10 [ Homo sapiens (human) ]

Gene ID: 57181, updated on 1-Mar-2024

Summary

Official Symbol
SLC39A10provided by HGNC
Official Full Name
solute carrier family 39 member 10provided by HGNC
Primary source
HGNC:HGNC:20861
See related
Ensembl:ENSG00000196950 MIM:608733; AllianceGenome:HGNC:20861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIP10; LZT-Hs2
Summary
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in thyroid (RPKM 12.9), brain (RPKM 12.5) and 21 other tissues See more
Orthologs
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Genomic context

See SLC39A10 in Genome Data Viewer
Location:
2q32.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (195613029..195737700)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (196097362..196222040)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (196521682..196602424)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:196434945-196435535 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:196450653-196451242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:196452793-196453292 Neighboring gene long intergenic non-protein coding RNA 1827 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:196477499-196478360 Neighboring gene adenosylhomocysteinase pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16889 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12199 Neighboring gene RNA, U6 small nuclear 915, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:196559503-196560702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:196569194-196569694 Neighboring gene uncharacterized LOC107985972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:196608945-196609445 Neighboring gene dynein axonemal heavy chain 7 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:196652546-196653745 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:196722945-196724144 Neighboring gene E2F transcription factor 3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC39A10 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of solute carrier family 39 (zinc transporter), member 10 (SLC39A10) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ31108, MGC126565, MGC138428, DKFZp781L10106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables monoatomic cation:bicarbonate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in bicarbonate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular zinc ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in zinc ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in zinc ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc transporter ZIP10
Names
ZIP-10
ZRT/IRT-like protein 10
solute carrier family 39 (metal ion transporter), member 10
solute carrier family 39 (zinc transporter), member 10
zinc transporter 10
zrt- and Irt-like protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127257.2NP_001120729.1  zinc transporter ZIP10 precursor

    See identical proteins and their annotated locations for NP_001120729.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC013274, AI693720, CR749813
    Consensus CDS
    CCDS33353.1
    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
    Related
    ENSP00000386766.3, ENST00000409086.7
    Conserved Domains (1) summary
    pfam02535
    Location:404819
    Zip; ZIP Zinc transporter
  2. NM_020342.3NP_065075.1  zinc transporter ZIP10 precursor

    See identical proteins and their annotated locations for NP_065075.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC013274, AI693720, AK291241
    Consensus CDS
    CCDS33353.1
    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
    Related
    ENSP00000352655.5, ENST00000359634.10
    Conserved Domains (1) summary
    pfam02535
    Location:404819
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    195613029..195737700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511504.3XP_011509806.1  zinc transporter ZIP10 isoform X4

    See identical proteins and their annotated locations for XP_011509806.1

    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
    Conserved Domains (1) summary
    pfam02535
    Location:404819
    Zip; ZIP Zinc transporter
  2. XM_005246689.5XP_005246746.3  zinc transporter ZIP10 isoform X1

  3. XM_047445143.1XP_047301099.1  zinc transporter ZIP10 isoform X4

    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
  4. XM_011511507.3XP_011509809.2  zinc transporter ZIP10 isoform X5

  5. XM_017004523.2XP_016860012.2  zinc transporter ZIP10 isoform X6

  6. XM_047445144.1XP_047301100.1  zinc transporter ZIP10 isoform X4

    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
  7. XM_047445141.1XP_047301097.1  zinc transporter ZIP10 isoform X2

  8. XM_047445142.1XP_047301098.1  zinc transporter ZIP10 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    196097362..196222040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343084.1XP_054199059.1  zinc transporter ZIP10 isoform X4

    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
  2. XM_054343085.1XP_054199060.1  zinc transporter ZIP10 isoform X4

    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
  3. XM_054343081.1XP_054199056.1  zinc transporter ZIP10 isoform X7

  4. XM_054343087.1XP_054199062.1  zinc transporter ZIP10 isoform X8

  5. XM_054343088.1XP_054199063.1  zinc transporter ZIP10 isoform X9

  6. XM_054343086.1XP_054199061.1  zinc transporter ZIP10 isoform X4

    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
  7. XM_054343082.1XP_054199057.1  zinc transporter ZIP10 isoform X2

  8. XM_054343083.1XP_054199058.1  zinc transporter ZIP10 isoform X3