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    TREM2 triggering receptor expressed on myeloid cells 2 [ Homo sapiens (human) ]

    Gene ID: 54209, updated on 11-Apr-2024

    Summary

    Official Symbol
    TREM2provided by HGNC
    Official Full Name
    triggering receptor expressed on myeloid cells 2provided by HGNC
    Primary source
    HGNC:HGNC:17761
    See related
    Ensembl:ENSG00000095970 MIM:605086; AllianceGenome:HGNC:17761
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c
    Summary
    This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
    Expression
    Broad expression in brain (RPKM 11.5), lung (RPKM 7.7) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    6p21.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41158508..41163116, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (40987077..40991685, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41126246..41130854, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene nuclear transcription factor Y subunit alpha Neighboring gene MPRA-validated peak5800 silencer Neighboring gene ADCY10 pseudogene 1 Neighboring gene triggering receptor expressed on myeloid cells like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17174 Neighboring gene uncharacterized LOC107986595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41159081-41159588 Neighboring gene triggering receptor expressed on myeloid cells like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2
    MedGen: C4748657 OMIM: 618193 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
    EBI GWAS Catalog
    Variant of TREM2 associated with the risk of Alzheimer's disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of triggering receptor expressed on myeloid cells 2 (TREM2) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables amyloid-beta binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables apolipoprotein A-I binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables apolipoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables high-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables lipid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipoteichoic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables low-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidoglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylethanolamine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables sulfatide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables very-low-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect CXCL12-activated CXCR4 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in amyloid-beta clearance by cellular catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in amyloid-beta clearance by cellular catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic cell clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in astrocyte activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to amyloid-beta ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to lipoteichoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to peptidoglycan IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in complement-mediated synapse pruning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within_positive_effect defense response to Gram-negative bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dendritic cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dendritic spine maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in detection of lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of lipoteichoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of peptidoglycan IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in excitatory synapse pruning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in humoral immune response TAS
    Traceable Author Statement
    more info
     
    involved_in import into cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_positive_effect memory IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_positive_effect memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microglial cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in microglial cell activation involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microglial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of NLRP3 inflammasome complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of NLRP3 inflammasome complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of amyloid fibril formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of astrocyte activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of autophagic cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cholesterol storage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cytokine production involved in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of fat cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of glial cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of inflammatory response to antigenic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of macrophage colony-stimulating factor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuroinflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of p38MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of sequestering of triglyceride ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of toll-like receptor 2 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of toll-like receptor 4 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phagocytosis, engulfment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phagocytosis, recognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ATP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of C-C chemokine receptor CCR7 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of CAMKK-AMPK signaling cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of CD40 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of amyloid-beta clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of amyloid-beta clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of antigen processing and presentation of peptide antigen via MHC class II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of complement activation, classical pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of engulfment of apoptotic cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of establishment of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of high-density lipoprotein particle clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of inward rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of low-density lipoprotein particle clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of macrophage fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of microglial cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of microglial cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of microglial cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of microglial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of microglial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phagocytosis, engulfment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of positive regulation of phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of proteasomal protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of synapse pruning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_negative_effect pyroptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cytokine production involved in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of hippocampal neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of macrophage inflammatory protein 1 alpha production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of peptidyl-tyrosine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of plasma membrane bounded cell projection organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of plasma membrane bounded cell projection organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of plasma membrane bounded cell projection organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of resting membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of toll-like receptor 6 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in respiratory burst after phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to axon injury IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to axon injury ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_positive_effect social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    triggering receptor expressed on myeloid cells 2
    Names
    triggering receptor expressed on monocytes 2
    triggering receptor expressed on myeloid cells 2a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011561.1 RefSeqGene

      Range
      4999..9679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_631

    mRNA and Protein(s)

    1. NM_001271821.2NP_001258750.1  triggering receptor expressed on myeloid cells 2 precursor isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), alternately referred to as TREM-2V, lacks a 3' coding exon which results in a frameshift, compared to variant 1. The resulting isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AB062787
      Consensus CDS
      CCDS64422.1
      UniProtKB/Swiss-Prot
      Q9NZC2
      Related
      ENSP00000342651.4, ENST00000338469.3
      Conserved Domains (1) summary
      cl11960
      Location:23128
      Ig; Immunoglobulin domain
    2. NM_018965.4NP_061838.1  triggering receptor expressed on myeloid cells 2 precursor isoform 1 precursor

      See identical proteins and their annotated locations for NP_061838.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF213457, BC032362
      Consensus CDS
      CCDS4852.1
      UniProtKB/Swiss-Prot
      Q8N5H8, Q8WYN6, Q9NZC2
      UniProtKB/TrEMBL
      A6NDG2, Q5TCX1
      Related
      ENSP00000362205.3, ENST00000373113.8
      Conserved Domains (2) summary
      smart00410
      Location:26111
      IG_like; Immunoglobulin like
      cl11960
      Location:23128
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      41158508..41163116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      40987077..40991685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)