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Trem2 triggering receptor expressed on myeloid cells 2 [ Mus musculus (house mouse) ]

Gene ID: 83433, updated on 28-Nov-2021

Summary

Official Symbol
Trem2provided by MGI
Official Full Name
triggering receptor expressed on myeloid cells 2provided by MGI
Primary source
MGI:MGI:1913150
See related
Ensembl:ENSMUSG00000023992
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TREM-2; Trem2a; Trem2b; Trem2c
Summary
The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 19.6), ovary adult (RPKM 10.2) and 20 other tissues See more
Orthologs
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Genomic context

See Trem2 in Genome Data Viewer
Location:
17; 17 C
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48653429..48659304)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48346401..48352276)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (48485726..48491598)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene triggering receptor expressed on myeloid cells-like 2 Neighboring gene RIKEN cDNA B430306N03 gene Neighboring gene triggering receptor expressed on myeloid cells-like 1 Neighboring gene nuclear transcription factor-Y alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables apolipoprotein A-I binding ISO
Inferred from Sequence Orthology
more info
 
enables apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables high-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
enables lipoteichoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables low-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylethanolamine binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables sulfatide binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables very-low-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within_positive_effect CXCL12-activated CXCR4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in amyloid-beta clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in amyloid-beta clearance by cellular catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in amyloid-beta clearance by cellular catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in astrocyte activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to lipid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipoteichoic acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to oxidised low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to peptidoglycan IDA
Inferred from Direct Assay
more info
PubMed 
involved_in complement-mediated synapse pruning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic spine maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of lipoteichoic acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of peptidoglycan IDA
Inferred from Direct Assay
more info
PubMed 
involved_in excitatory synapse pruning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in import into cell IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in innate immune response IC
Inferred by Curator
more info
PubMed 
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipopolysaccharide-mediated signaling pathway IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within memory ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in microglial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microglial cell activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microglial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of NLRP3 inflammasome complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amyloid fibril formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of astrocyte activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of autophagic cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cholesterol storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fat cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of macrophage colony-stimulating factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuroinflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of sequestering of triglyceride IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of toll-like receptor 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phagocytosis, engulfment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagocytosis, recognition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of C-C chemokine receptor CCR7 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of CAMKK-AMPK signaling cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of CD40 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of TOR signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of amyloid-beta clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of antigen processing and presentation of peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of complement activation, classical pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of engulfment of apoptotic cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of high-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inward rectifier potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of microglial cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of microglial cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of microglial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microglial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of microglial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of microglial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synapse pruning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_negative_effect pyroptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of hippocampal neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of intracellular signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of macrophage inflammatory protein 1 alpha production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of peptidyl-tyrosine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of plasma membrane bounded cell projection organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of plasma membrane bounded cell projection organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of plasma membrane bounded cell projection organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of resting membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of toll-like receptor 6 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in respiratory burst after phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to axon injury ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within social behavior ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in intrinsic component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
triggering receptor expressed on myeloid cells 2
Names
triggering receptor expressed on monocytes 2
triggering receptor expressed on myeloid cells 2a
triggering receptor expressed on myeloid cells 2b
triggering receptor expressed on myeloid cells 2c

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272078.1NP_001259007.1  triggering receptor expressed on myeloid cells 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001259007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus that lacks a transmembrane domain, compared to isoform 1.
    Source sequence(s)
    AC166164, AK039477, AY187009, BY541740
    Consensus CDS
    CCDS70825.1
    UniProtKB/Swiss-Prot
    Q99NH8
    Related
    ENSMUSP00000108863.4, ENSMUST00000113237.4
    Conserved Domains (1) summary
    cl11960
    Location:23128
    Ig; Immunoglobulin domain
  2. NM_031254.3NP_112544.1  triggering receptor expressed on myeloid cells 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_112544.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC166164, AK039477, BY541740
    Consensus CDS
    CCDS28865.1
    UniProtKB/Swiss-Prot
    Q99NH8
    Related
    ENSMUSP00000024791.9, ENSMUST00000024791.15
    Conserved Domains (2) summary
    smart00410
    Location:23111
    IG_like; Immunoglobulin like
    cl11960
    Location:23128
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48653429..48659304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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