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    PDK4 pyruvate dehydrogenase kinase 4 [ Homo sapiens (human) ]

    Gene ID: 5166, updated on 17-Jun-2024

    Summary

    Official Symbol
    PDK4provided by HGNC
    Official Full Name
    pyruvate dehydrogenase kinase 4provided by HGNC
    Primary source
    HGNC:HGNC:8812
    See related
    Ensembl:ENSG00000004799 MIM:602527; AllianceGenome:HGNC:8812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 319.9), adrenal (RPKM 136.4) and 18 other tissues See more
    Orthologs
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    Genomic context

    See PDK4 in Genome Data Viewer
    Location:
    7q21.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (95583499..95596516, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (96819655..96832673, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (95212811..95225828, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:95099762-95100961 Neighboring gene uncharacterized LOC107986823 Neighboring gene ankyrin repeat and SOCS box containing 4 Neighboring gene Sharpr-MPRA regulatory region 3033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:95156819-95157320 Neighboring gene uncharacterized LOC124901699 Neighboring gene Sharpr-MPRA regulatory region 6047 Neighboring gene PDK4 antisense RNA 1 Neighboring gene VISTA enhancer hs1831 Neighboring gene VISTA enhancer hs2505 Neighboring gene uncharacterized LOC107986746

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr enhances PPARbeta/delta-induced PDK4, carnitine palmitoyltransferase I (CPT1), and acetyl-coenzyme A acyltransferase 2 (ACAA2) mRNA expression in cells PubMed
    vpr HIV-1 Vpr enhances PPARbeta/delta agonist GW501516-induced pyruvate dehydrogenase kinase 4 (PDK4) protein expression and phosphorylation of pyruvate dehydrogenase alpha 1 (PDHE1alpha) at serine 293 in cells PubMed
    matrix gag HIV-1 MA increases PDK4 mRNA expression in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ40832

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to fatty acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of anoikis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of bone resorption IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cellular ketone metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of pH ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    pyruvate dehydrogenase kinase, isozyme 4
    Names
    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
    [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
    pyruvate dehydrogenase kinase, isoenzyme 4
    pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial
    NP_002603.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047008.1 RefSeqGene

      Range
      5098..18115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002612.4NP_002603.1  pyruvate dehydrogenase kinase, isozyme 4

      See identical proteins and their annotated locations for NP_002603.1

      Status: REVIEWED

      Source sequence(s)
      AF334710, BC040239, DA923767, DB035430, U54617
      Consensus CDS
      CCDS5643.1
      UniProtKB/Swiss-Prot
      Q16654
      UniProtKB/TrEMBL
      A4D1H4, Q53FG1
      Related
      ENSP00000005178.5, ENST00000005178.6
      Conserved Domains (2) summary
      smart00387
      Location:245365
      HATPase_c; Histidine kinase-like ATPases
      pfam10436
      Location:34195
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      95583499..95596516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      96819655..96832673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)