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Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 [ Mus musculus (house mouse) ]

Gene ID: 27273, updated on 23-Jun-2021

Summary

Official Symbol
Pdk4provided by MGI
Official Full Name
pyruvate dehydrogenase kinase, isoenzyme 4provided by MGI
Primary source
MGI:MGI:1351481
See related
Ensembl:ENSMUSG00000019577
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AV005916
Expression
Biased expression in heart adult (RPKM 42.2), adrenal adult (RPKM 18.7) and 12 other tissues See more
Orthologs
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Genomic context

See Pdk4 in Genome Data Viewer
Location:
6 A1; 6 2.06 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (5483351..5496278, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (5483351..5496278, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (5433351..5446278, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38762 Neighboring gene ankyrin repeat and SOCS box-containing 4 Neighboring gene predicted gene, 34470 Neighboring gene predicted gene, 46983

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to fatty acid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of acetyl-CoA biosynthetic process from pyruvate TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cellular ketone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Names
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
pyruvate dehydrogenase kinase 4
NP_038771.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013743.2NP_038771.1  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

    See identical proteins and their annotated locations for NP_038771.1

    Status: PROVISIONAL

    Source sequence(s)
    AC023174
    Consensus CDS
    CCDS19902.1
    UniProtKB/Swiss-Prot
    O70571
    UniProtKB/TrEMBL
    Q544J2
    Related
    ENSMUSP00000019721.5, ENSMUST00000019721.7
    Conserved Domains (3) summary
    smart00387
    Location:245365
    HATPase_c; Histidine kinase-like ATPases
    COG0642
    Location:245373
    BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
    pfam10436
    Location:34195
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    5483351..5496278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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