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PDK4 pyruvate dehydrogenase kinase 4 [ Homo sapiens (human) ]

Gene ID: 5166, updated on 19-Sep-2021

Summary

Official Symbol
PDK4provided by HGNC
Official Full Name
pyruvate dehydrogenase kinase 4provided by HGNC
Primary source
HGNC:HGNC:8812
See related
Ensembl:ENSG00000004799 MIM:602527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 319.9), adrenal (RPKM 136.4) and 18 other tissues See more
Orthologs
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Genomic context

See PDK4 in Genome Data Viewer
Location:
7q21.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (95583499..95596516, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (95212811..95225828, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986823 Neighboring gene ankyrin repeat and SOCS box containing 4 Neighboring gene PDK4 antisense RNA 1 Neighboring gene VISTA enhancer hs1831 Neighboring gene VISTA enhancer hs2505

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr enhances PPARbeta/delta-induced PDK4, carnitine palmitoyltransferase I (CPT1), and acetyl-coenzyme A acyltransferase 2 (ACAA2) mRNA expression in cells PubMed
vpr HIV-1 Vpr enhances PPARbeta/delta agonist GW501516-induced pyruvate dehydrogenase kinase 4 (PDK4) protein expression and phosphorylation of pyruvate dehydrogenase alpha 1 (PDHE1alpha) at serine 293 in cells PubMed
matrix gag HIV-1 MA increases PDK4 mRNA expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40832

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cellular response to fatty acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate TAS
Traceable Author Statement
more info
 
involved_in regulation of bone resorption IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cellular ketone metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of pH ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pyruvate dehydrogenase kinase, isozyme 4
Names
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
pyruvate dehydrogenase kinase, isoenzyme 4
pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial
NP_002603.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047008.1 RefSeqGene

    Range
    5098..18115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002612.4NP_002603.1  pyruvate dehydrogenase kinase, isozyme 4

    See identical proteins and their annotated locations for NP_002603.1

    Status: REVIEWED

    Source sequence(s)
    AF334710, BC040239, DA923767, DB035430, U54617
    Consensus CDS
    CCDS5643.1
    UniProtKB/Swiss-Prot
    Q16654
    UniProtKB/TrEMBL
    A4D1H4
    Related
    ENSP00000005178.5, ENST00000005178.6
    Conserved Domains (2) summary
    smart00387
    Location:245365
    HATPase_c; Histidine kinase-like ATPases
    pfam10436
    Location:34195
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    95583499..95596516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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