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    NFYA nuclear transcription factor Y subunit alpha [ Homo sapiens (human) ]

    Gene ID: 4800, updated on 17-Jun-2024

    Summary

    Official Symbol
    NFYAprovided by HGNC
    Official Full Name
    nuclear transcription factor Y subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:7804
    See related
    Ensembl:ENSG00000001167 MIM:189903; AllianceGenome:HGNC:7804
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HAP2; CBF-A; CBF-B; NF-YA
    Summary
    The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 5.4), brain (RPKM 3.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NFYA in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41072974..41102403)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (40901531..40930960)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41040713..41070142)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene translocator protein 2 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17173 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene MPRA-validated peak5800 silencer Neighboring gene ADCY10 pseudogene 1 Neighboring gene triggering receptor expressed on myeloid cells like 1 Neighboring gene triggering receptor expressed on myeloid cells 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human nuclear transcription factor Y, alpha (NFYA) at amino acid residues 238-239 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11236

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CCAAT-binding factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of CCAAT-binding factor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear transcription factor Y subunit alpha
    Names
    CAAT-box DNA binding protein subunit A
    CCAAT-binding transcription factor subunit B
    HAP2 CCAAT-binding protein
    NFYA transcript
    Transcription factor NF-Y, A subunit
    nuclear transcription factor Y subunit A
    nuclear transcription factor Y, alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002505.5NP_002496.1  nuclear transcription factor Y subunit alpha isoform 1

      See identical proteins and their annotated locations for NP_002496.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) includes alternate exon B, resulting in the long isoform, isoform 1.
      Source sequence(s)
      AL031778, BM561405, BQ184804, X59711
      Consensus CDS
      CCDS4849.1
      UniProtKB/Swiss-Prot
      P23511, Q8IXU0
      Related
      ENSP00000345702.6, ENST00000341376.11
      Conserved Domains (1) summary
      pfam02045
      Location:263318
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
    2. NM_021705.4NP_068351.1  nuclear transcription factor Y subunit alpha isoform 2

      See identical proteins and their annotated locations for NP_068351.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing alternate exon B, resulting in the short isoform, isoform 2.
      Source sequence(s)
      AL031778, BC039244, BM561405, BQ184804
      Consensus CDS
      CCDS4850.1
      Related
      ENSP00000229418.6, ENST00000353205.5
      Conserved Domains (1) summary
      pfam02045
      Location:234289
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      41072974..41102403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      40901531..40930960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)