Nfya nuclear transcription factor-Y alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfyaprovided by MGI
Official Full Name: nuclear transcription factor-Y alphaprovided by MGI
Primary source: MGI:MGI:97316
See related: Ensembl:ENSMUSG00000023994 AllianceGenome:MGI:97316
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cbf-b; SEZ10; SEZ-10
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of stem cell proliferation; positive regulation of transcription, DNA-templated; and regulation of stem cell population maintenance. Located in nucleus. Is expressed in several structures, including branchial arch; cerebral cortex; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human NFYA (nuclear transcription factor Y subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 28.3), ovary adult (RPKM 24.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 23.99 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (48693913..48716848, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (48386885..48409820, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear Factor-Y in Mouse Pancreatic beta-Cells Plays a Crucial Role in Glucose Homeostasis by Regulating beta-Cell Mass and Insulin Secretion.
Title: Nuclear Factor-Y in Mouse Pancreatic β-Cells Plays a Crucial Role in Glucose Homeostasis by Regulating β-Cell Mass and Insulin Secretion.
Nuclear factor Y participates in alcoholic liver disease by activating SREBP1 expression in mice.
Title: Nuclear factor Y participates in alcoholic liver disease by activating SREBP1 expression in mice.
The Switch from NF-YAl to NF-YAs Isoform Impairs Myotubes Formation.
Title: The Switch from NF-YAl to NF-YAs Isoform Impairs Myotubes Formation.
Through genome-wide studies in mouse embryonic stem cells study finds that NF-Y is essential for the maintenance of the nucleosome-depleted region at gene promoters. Depletion of the NF-YA protein leads to the accumulation of ectopic nucleosomes over the transcription start site, reducing promoter accessibility.
Title: NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region.
The results reveal a previously unrecognized physiological function of NFYA in controlling glucose metabolism by up-regulating the gluconeogenic genes Pck1 and G6pc.
Title: Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice.
Data show that nuclear factor Y (NF-Y) binds to the inverted CCAAT element (ICE) in the Fatty acid synthase (Fasn) promoter specifically in refeeding states.
Title: A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes.
findings may point to a possible role of NF-YA in stress conditions that occur in chronic obesity, ER stress might be involved in the pathogenesis of obesity through NF-YA depletion.
Title: Obesity-induced endoplasmic reticulum stress suppresses nuclear factor-Y expression.
we conclude that NF-Y and YY1 are important for the basal transcription of Pcyt2 and that NF-Y is involved in the inhibitory effects of 25-HC on Pcyt2 transcription.
Title: Transcriptional suppression of CTP:phosphoethanolamine cytidylyltransferase by 25-hydroxycholesterol is mediated by nuclear factor-Y and Yin Yang 1.
these results indicate that the transcription factor NF-Y regulates the proximal promoter activity of mouse Col11a1 gene in chondrocytes
Title: Nuclear factor Y (NF-Y) regulates the proximal promoter activity of the mouse collagen α1(XI) gene (Col11a1) in chondrocytes.
these results raise an exciting possibility that targeting CDK1 or NF-Y in the diseased heart may inhibit fibrosis and subsequently confer cardioprotection.
Title: A novel β-adrenergic response element regulates both basal and agonist-induced expression of cyclin-dependent kinase 1 gene in cardiac fibroblasts.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nfya (e-PCR), detects polymorphism
- UniSTS:526901

RH125554 (e-PCR)
- UniSTS:162368

RH139239 (e-PCR)
- UniSTS:221325

Homology

Homologs of the Nfya gene: The Nfya gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 346 organisms have orthologs with human gene Nfya
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IGI Inferred from Genetic Interaction more info	PubMed
contributes_to transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in histone H3-K4 trimethylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of histone acetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CCAAT-binding factor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of CCAAT-binding factor complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear transcription factor Y subunit alpha

Names: CAAT box DNA-binding protein subunit A; nuclear transcription factor Y subunit A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110832.2 → NP_001104302.1 nuclear transcription factor Y subunit alpha isoform a

See identical proteins and their annotated locations for NP_001104302.1

Status: VALIDATED

Source sequence(s)

AC166164

Consensus CDS

CCDS50142.1

UniProtKB/TrEMBL

A0A6P7QKS8, A0A8C6GM79, Q9DBV7

Related

ENSMUSP00000043909.8, ENSMUST00000046719.14

Conserved Domains (1) summary

pfam02045
Location:263 → 318

CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
NM_001347401.2 → NP_001334330.1 nuclear transcription factor Y subunit alpha isoform c

Status: VALIDATED

Source sequence(s)

AC166164

Consensus CDS

CCDS84321.1

UniProtKB/Swiss-Prot

P23708

UniProtKB/TrEMBL

A0A6P5RAL0

Conserved Domains (1) summary

pfam02045
Location:262 → 317

CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
NM_001347402.2 → NP_001334331.1 nuclear transcription factor Y subunit alpha isoform d

Status: VALIDATED

Source sequence(s)

AC166164

Consensus CDS

CCDS84320.1

UniProtKB/Swiss-Prot

P23708

UniProtKB/TrEMBL

A0A0R4J1Y8, A0A6P5RAL5

Related

ENSMUSP00000124404.2, ENSMUST00000159063.8

Conserved Domains (1) summary

pfam02045
Location:228 → 283

CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
NM_001374803.2 → NP_001361732.1 nuclear transcription factor Y subunit alpha isoform e

Status: VALIDATED

Source sequence(s)

AC166164

Consensus CDS

CCDS89116.1

UniProtKB/TrEMBL

A0A6P5R487, E0CYF3

Related

ENSMUSP00000124245.2, ENSMUST00000160319.8

Conserved Domains (1) summary

pfam02045
Location:257 → 312

CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
NM_001413334.1 → NP_001400263.1 nuclear transcription factor Y subunit alpha isoform h

Status: VALIDATED

Source sequence(s)

AC166164
NM_001413335.1 → NP_001400264.1 nuclear transcription factor Y subunit alpha isoform g

Status: VALIDATED

Source sequence(s)

AC166164
NM_001413336.1 → NP_001400265.1 nuclear transcription factor Y subunit alpha isoform f

Status: VALIDATED

Source sequence(s)

AC166164

UniProtKB/TrEMBL

A0A6P5RA21
NM_001413337.1 → NP_001400266.1 nuclear transcription factor Y subunit alpha isoform i

Status: VALIDATED

Source sequence(s)

AC166164
NM_001413338.1 → NP_001400267.1 nuclear transcription factor Y subunit alpha isoform j

Status: VALIDATED

Source sequence(s)

AC166164
NM_001413339.1 → NP_001400268.1 nuclear transcription factor Y subunit alpha isoform k

Status: VALIDATED

Source sequence(s)

AC166164
NM_001413340.1 → NP_001400269.1 nuclear transcription factor Y subunit alpha isoform l

Status: VALIDATED

Source sequence(s)

AC166164
NM_001413341.1 → NP_001400270.1 nuclear transcription factor Y subunit alpha isoform m

Status: VALIDATED

Source sequence(s)

AC166164
NM_001413342.1 → NP_001400271.1 nuclear transcription factor Y subunit alpha isoform n

Status: VALIDATED

Source sequence(s)

AC166164
NM_001413343.1 → NP_001400272.1 nuclear transcription factor Y subunit alpha isoform o

Status: VALIDATED

Source sequence(s)

AC166164
NM_001413344.1 → NP_001400273.1 nuclear transcription factor Y subunit alpha isoform p

Status: VALIDATED

Source sequence(s)

AC166164
NM_010913.3 → NP_035043.1 nuclear transcription factor Y subunit alpha isoform b

See identical proteins and their annotated locations for NP_035043.1

Status: VALIDATED

Source sequence(s)

AC166164

Consensus CDS

CCDS28867.1

UniProtKB/Swiss-Prot

P23708

UniProtKB/TrEMBL

A0A6P5RGB3, A0A8C6MRW8, Q3UP82, Q9DBV7

Related

ENSMUSP00000123785.2, ENSMUST00000162460.8

Conserved Domains (1) summary

pfam02045
Location:234 → 289

CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

48693913..48716848 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317292.3 → XP_017172781.1 nuclear transcription factor Y subunit alpha isoform X2

Conserved Domains (1) summary

pfam02045
Location:262 → 317

CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
XM_030249554.2 → XP_030105414.1 nuclear transcription factor Y subunit alpha isoform X7

Conserved Domains (1) summary

pfam02045
Location:228 → 283

CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
XM_030249553.1 → XP_030105413.1 nuclear transcription factor Y subunit alpha isoform X5

Conserved Domains (1) summary

pfam02045
Location:256 → 311

CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
XM_030249551.2 → XP_030105411.1 nuclear transcription factor Y subunit alpha isoform X1

Related

ENSMUSP00000077853.7, ENSMUST00000078800.13

Conserved Domains (1) summary

pfam02045
Location:262 → 317

CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
XM_006523793.3 → XP_006523856.1 nuclear transcription factor Y subunit alpha isoform X3

Conserved Domains (1) summary

pfam02045
Location:261 → 316

CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
XM_006523795.3 → XP_006523858.1 nuclear transcription factor Y subunit alpha isoform X6

Conserved Domains (1) summary

pfam02045
Location:255 → 310

CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
XM_030249552.2 → XP_030105412.1 nuclear transcription factor Y subunit alpha isoform X4

Conserved Domains (1) summary

pfam02045
Location:256 → 311

CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B