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Nfya nuclear transcription factor-Y alpha [ Mus musculus (house mouse) ]

Gene ID: 18044, updated on 12-May-2024

Summary

Official Symbol
Nfyaprovided by MGI
Official Full Name
nuclear transcription factor-Y alphaprovided by MGI
Primary source
MGI:MGI:97316
See related
Ensembl:ENSMUSG00000023994 AllianceGenome:MGI:97316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cbf-b; SEZ10; SEZ-10
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of stem cell proliferation; positive regulation of transcription, DNA-templated; and regulation of stem cell population maintenance. Located in nucleus. Is expressed in several structures, including branchial arch; cerebral cortex; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human NFYA (nuclear transcription factor Y subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 28.3), ovary adult (RPKM 24.5) and 28 other tissues See more
Orthologs
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Genomic context

See Nfya in Genome Data Viewer
Location:
17 C; 17 23.99 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48693917..48716782, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48386885..48409820, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene triggering receptor expressed on myeloid cells 2 Neighboring gene triggering receptor expressed on myeloid cells-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E10961 Neighboring gene STARR-positive B cell enhancer ABC_E2492 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48549466-48549575 Neighboring gene STARR-positive B cell enhancer ABC_E7541 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 Neighboring gene predicted gene, 30283

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of CCAAT-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CCAAT-binding factor complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear transcription factor Y subunit alpha
Names
CAAT box DNA-binding protein subunit A
nuclear transcription factor Y subunit A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110832.2NP_001104302.1  nuclear transcription factor Y subunit alpha isoform a

    See identical proteins and their annotated locations for NP_001104302.1

    Status: VALIDATED

    Source sequence(s)
    AC166164
    Consensus CDS
    CCDS50142.1
    UniProtKB/TrEMBL
    Q8K2W1, Q9DBV7
    Related
    ENSMUSP00000043909.8, ENSMUST00000046719.14
    Conserved Domains (1) summary
    pfam02045
    Location:263318
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
  2. NM_001347401.2NP_001334330.1  nuclear transcription factor Y subunit alpha isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166164
    Consensus CDS
    CCDS84321.1
    UniProtKB/Swiss-Prot
    P23708
    UniProtKB/TrEMBL
    Q8K2W1
    Related
    ENSMUSP00000077853.7, ENSMUST00000078800.13
    Conserved Domains (1) summary
    pfam02045
    Location:262317
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
  3. NM_001347402.2NP_001334331.1  nuclear transcription factor Y subunit alpha isoform d

    Status: VALIDATED

    Source sequence(s)
    AC166164
    Consensus CDS
    CCDS84320.1
    UniProtKB/TrEMBL
    A0A0R4J1Y8, Q8K2W1
    Related
    ENSMUSP00000124404.2, ENSMUST00000159063.8
    Conserved Domains (1) summary
    pfam02045
    Location:228283
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
  4. NM_001374803.2NP_001361732.1  nuclear transcription factor Y subunit alpha isoform e

    Status: VALIDATED

    Source sequence(s)
    AC166164
    Consensus CDS
    CCDS89116.1
    UniProtKB/TrEMBL
    E0CYF3, Q8K2W1
    Related
    ENSMUSP00000124245.2, ENSMUST00000160319.8
    Conserved Domains (1) summary
    pfam02045
    Location:257312
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
  5. NM_001413334.1NP_001400263.1  nuclear transcription factor Y subunit alpha isoform h

    Status: VALIDATED

    Source sequence(s)
    AC166164
  6. NM_001413335.1NP_001400264.1  nuclear transcription factor Y subunit alpha isoform g

    Status: VALIDATED

    Source sequence(s)
    AC166164
  7. NM_001413336.1NP_001400265.1  nuclear transcription factor Y subunit alpha isoform f

    Status: VALIDATED

    Source sequence(s)
    AC166164
  8. NM_001413337.1NP_001400266.1  nuclear transcription factor Y subunit alpha isoform i

    Status: VALIDATED

    Source sequence(s)
    AC166164
  9. NM_001413338.1NP_001400267.1  nuclear transcription factor Y subunit alpha isoform j

    Status: VALIDATED

    Source sequence(s)
    AC166164
  10. NM_001413339.1NP_001400268.1  nuclear transcription factor Y subunit alpha isoform k

    Status: VALIDATED

    Source sequence(s)
    AC166164
  11. NM_001413340.1NP_001400269.1  nuclear transcription factor Y subunit alpha isoform l

    Status: VALIDATED

    Source sequence(s)
    AC166164
  12. NM_001413341.1NP_001400270.1  nuclear transcription factor Y subunit alpha isoform m

    Status: VALIDATED

    Source sequence(s)
    AC166164
  13. NM_001413342.1NP_001400271.1  nuclear transcription factor Y subunit alpha isoform n

    Status: VALIDATED

    Source sequence(s)
    AC166164
  14. NM_001413343.1NP_001400272.1  nuclear transcription factor Y subunit alpha isoform o

    Status: VALIDATED

    Source sequence(s)
    AC166164
  15. NM_001413344.1NP_001400273.1  nuclear transcription factor Y subunit alpha isoform p

    Status: VALIDATED

    Source sequence(s)
    AC166164
    Related
    ENSMUSP00000124501.2, ENSMUST00000159535.2
  16. NM_010913.3NP_035043.1  nuclear transcription factor Y subunit alpha isoform b

    See identical proteins and their annotated locations for NP_035043.1

    Status: VALIDATED

    Source sequence(s)
    AC166164
    Consensus CDS
    CCDS28867.1
    UniProtKB/TrEMBL
    Q3UP82, Q8K2W1
    Related
    ENSMUSP00000123785.2, ENSMUST00000162460.8
    Conserved Domains (1) summary
    pfam02045
    Location:234289
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48693917..48716782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)