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NFYA nuclear transcription factor Y subunit alpha [ Homo sapiens (human) ]

Gene ID: 4800, updated on 2-Nov-2024

Summary

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Official Symbol
NFYAprovided by HGNC
Official Full Name
nuclear transcription factor Y subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:7804
See related
Ensembl:ENSG00000001167 MIM:189903; AllianceGenome:HGNC:7804
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HAP2; CBF-A; CBF-B; NF-YA
Summary
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 5.4), brain (RPKM 3.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See NFYA in Genome Data Viewer
Location:
6p21.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41072974..41102403)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (40901531..40930960)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41040713..41070142)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene translocator protein 2 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17173 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene MPRA-validated peak5800 silencer Neighboring gene ADCY10 pseudogene 1 Neighboring gene triggering receptor expressed on myeloid cells like 1 Neighboring gene triggering receptor expressed on myeloid cells 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NF-YA overexpression protects from glutamine deprivation. Dolfini D, et al. Biochim Biophys Acta Mol Cell Res, 2020 Feb. PMID 31706909
  2. Direct non transcriptional role of NF-Y in DNA replication. Benatti P, et al. Biochim Biophys Acta, 2016 Apr. PMID 26732297
  3. NF-YA splice variants have different roles on muscle differentiation. Basile V, et al. Biochim Biophys Acta, 2016 Apr. PMID 26921500
  4. NF-YA promotes invasion and angiogenesis by upregulating EZH2-STAT3 signaling in human melanoma cells. Xu Z, et al. Oncol Rep, 2016 Jun. PMID 27109360
  5. Transcription factor NF-Y inhibits cell growth and decreases SOX2 expression in human embryonal carcinoma cell line NT2/D1. Mojsin M, et al. Biochemistry (Mosc), 2015 Feb. PMID 25756534

See all (145) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interaction between S100A2 and KPNA2 mediates NFYA nuclear import and is a novel therapeutic target for colorectal cancer metastasis.
    Title: The interaction between S100A2 and KPNA2 mediates NFYA nuclear import and is a novel therapeutic target for colorectal cancer metastasis.
  2. Myo-differentiation reporter screen reveals NF-Y as an activator of PAX3-FOXO1 in rhabdomyosarcoma.
    Title: Myo-differentiation reporter screen reveals NF-Y as an activator of PAX3-FOXO1 in rhabdomyosarcoma.
  3. NFYA promotes malignant behavior of triple-negative breast cancer in mice through the regulation of lipid metabolism.
    Title: NFYA promotes malignant behavior of triple-negative breast cancer in mice through the regulation of lipid metabolism.
  4. NFYAv1 is a Tumor-Promoting Transcript Associated with Poor Prognosis of Hepatocellular Carcinoma.
    Title: NFYAv1 is a Tumor-Promoting Transcript Associated with Poor Prognosis of Hepatocellular Carcinoma.
  5. KLF5 and NFYA factors as novel regulators of prostate cancer cell metabolism.
    Title: KLF5 and NFYA factors as novel regulators of prostate cancer cell metabolism.
  6. Alternative splicing of NF-YA promotes prostate cancer aggressiveness and represents a new molecular marker for clinical stratification of patients.
    Title: Alternative splicing of NF-YA promotes prostate cancer aggressiveness and represents a new molecular marker for clinical stratification of patients.
  7. Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.
    Title: Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.
  8. NF-YA promotes the cell proliferation and tumorigenic properties by transcriptional activation of SOX2 in cervical cancer.
    Title: NF-YA promotes the cell proliferation and tumorigenic properties by transcriptional activation of SOX2 in cervical cancer.
  9. Transcription factor competition at the gamma-globin promoters controls hemoglobin switching.
    Title: Transcription factor competition at the γ-globin promoters controls hemoglobin switching.
  10. NF-YA Overexpression in Lung Cancer: LUAD.
    Title: NF-YA Overexpression in Lung Cancer: LUAD.
Submit: New GeneRIF Correction See all GeneRIFs (70)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human nuclear transcription factor Y, alpha (NFYA) at amino acid residues 238-239 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11236

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of CCAAT-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCAAT-binding factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of CCAAT-binding factor complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nuclear transcription factor Y subunit alpha
Names
CAAT-box DNA binding protein subunit A
CCAAT-binding transcription factor subunit B
HAP2 CCAAT-binding protein
NFYA transcript
Transcription factor NF-Y, A subunit
nuclear transcription factor Y subunit A
nuclear transcription factor Y, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002505.5 → NP_002496.1  nuclear transcription factor Y subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_002496.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) includes alternate exon B, resulting in the long isoform, isoform 1.
    Source sequence(s)
    AL031778, BM561405, BQ184804, X59711
    Consensus CDS
    CCDS4849.1
    UniProtKB/Swiss-Prot
    P23511, Q8IXU0
    Related
    ENSP00000345702.6, ENST00000341376.11
    Conserved Domains (1) summary
    pfam02045
    Location:263 → 318
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

  2. NM_021705.4 → NP_068351.1  nuclear transcription factor Y subunit alpha isoform 2

    See identical proteins and their annotated locations for NP_068351.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing alternate exon B, resulting in the short isoform, isoform 2.
    Source sequence(s)
    AL031778, BC039244, BM561405, BQ184804
    Consensus CDS
    CCDS4850.1
    Related
    ENSP00000229418.6, ENST00000353205.5
    Conserved Domains (1) summary
    pfam02045
    Location:234 → 289
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    41072974..41102403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    40901531..40930960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23511.2 GenPept UniProtKB/Swiss-Prot:P23511

Gene LinkOut

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