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NFYA nuclear transcription factor Y subunit alpha [ Homo sapiens (human) ]

Gene ID: 4800, updated on 2-Apr-2019

Summary

Official Symbol
NFYAprovided by HGNC
Official Full Name
nuclear transcription factor Y subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:7804
See related
Ensembl:ENSG00000001167 MIM:189903
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HAP2; CBF-A; CBF-B; NF-YA
Summary
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 5.4), brain (RPKM 3.2) and 25 other tissues See more
Orthologs

Genomic context

See NFYA in Genome Data Viewer
Location:
6p21.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (41072968..41102407)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41040707..41070146)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene translocator protein 2 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene ADCY10 pseudogene 1 Neighboring gene uncharacterized LOC105375056 Neighboring gene triggering receptor expressed on myeloid cells like 1 Neighboring gene triggering receptor expressed on myeloid cells 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human nuclear transcription factor Y, alpha (NFYA) at amino acid residues 238-239 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11236

Gene Ontology Provided by GOA

Process Evidence Code Pubs
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cholesterol biosynthetic process TAS
Traceable Author Statement
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
CCAAT-binding factor complex IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear transcription factor Y subunit alpha
Names
CAAT-box DNA binding protein subunit A
CCAAT-binding transcription factor subunit B
HAP2 CCAAT-binding protein
Transcription factor NF-Y, A subunit
nuclear transcription factor Y subunit A
nuclear transcription factor Y, alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002505.4NP_002496.1  nuclear transcription factor Y subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_002496.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) includes alternate exon B, resulting in the long isoform, isoform 1.
    Source sequence(s)
    AL031778, BM561405, BQ184804, X59711
    Consensus CDS
    CCDS4849.1
    UniProtKB/Swiss-Prot
    P23511
    Related
    ENSP00000345702.6, ENST00000341376.10
    Conserved Domains (1) summary
    pfam02045
    Location:263318
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
  2. NM_021705.3NP_068351.1  nuclear transcription factor Y subunit alpha isoform 2

    See identical proteins and their annotated locations for NP_068351.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing alternate exon B, resulting in the short isoform, isoform 2.
    Source sequence(s)
    AL031778, BC039244, BM561405, BQ184804
    Consensus CDS
    CCDS4850.1
    UniProtKB/Swiss-Prot
    P23511
    UniProtKB/TrEMBL
    A0A024RD22
    Related
    ENSP00000229418.6, ENST00000353205.5
    Conserved Domains (1) summary
    pfam02045
    Location:234289
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    41072968..41102407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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