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    TRIM37 tripartite motif containing 37 [ Homo sapiens (human) ]

    Gene ID: 4591, updated on 26-Jul-2021

    Summary

    Official Symbol
    TRIM37provided by HGNC
    Official Full Name
    tripartite motif containing 37provided by HGNC
    Primary source
    HGNC:HGNC:7523
    See related
    Ensembl:ENSG00000108395 MIM:605073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MUL; POB1; TEF3
    Summary
    This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020]
    Expression
    Broad expression in testis (RPKM 19.8), brain (RPKM 14.1) and 23 other tissues See more
    Orthologs
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    Genomic context

    See TRIM37 in Genome Data Viewer
    Location:
    17q22
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (58968010..59106880, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (57060010..57184241, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1E Neighboring gene RNA, U6 small nuclear 518, pseudogene Neighboring gene ribosomal protein S12 pseudogene 30 Neighboring gene RNA, 7SL, cytoplasmic 716, pseudogene Neighboring gene RNA, U2 small nuclear 58, pseudogene Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene microRNA 454

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Meta-analysis identifies four new loci associated with testicular germ cell tumor.
    GeneReviews: Not available
    Mulibrey nanism syndrome
    MedGen: C0524582 OMIM: 253250 GeneReviews: Not available
    Compare labs

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0898

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tumor necrosis factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables tumor necrosis factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in aggresome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone H2A monoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone H2A-K119 monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H2A-K119 monoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in aggresome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in aggresome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM37
    Names
    RING-B-box-coiled-coil protein
    RING-type E3 ubiquitin transferase TRIM37
    mulibrey nanism protein
    NP_001005207.1
    NP_001307916.1
    NP_001307917.1
    NP_001307918.1
    NP_001307919.1
    NP_001340011.1
    NP_001340012.1
    NP_001340013.1
    NP_001340014.1
    NP_001340015.1
    NP_056109.1
    XP_005257442.1
    XP_011523133.1
    XP_011523134.1
    XP_011523135.1
    XP_011523136.1
    XP_011523138.1
    XP_016880151.1
    XP_016880152.1
    XP_016880153.1
    XP_016880154.1
    XP_016880156.1
    XP_016880158.1
    XP_016880159.1
    XP_016880160.1
    XP_016880161.1
    XP_016880162.1
    XP_024306533.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009298.1 RefSeqGene

      Range
      5026..129257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001005207.5NP_001005207.1  E3 ubiquitin-protein ligase TRIM37 isoform a

      See identical proteins and their annotated locations for NP_001005207.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) and variant 1 encode the same isoform (a).
      Source sequence(s)
      AI307801, AK292459, BC036012, DC351295
      Consensus CDS
      CCDS45746.1
      UniProtKB/Swiss-Prot
      O94972
      Related
      ENSP00000376785.3, ENST00000393066.7
      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      cd00162
      Location:1558
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90132
      zf-B_box; B-box zinc finger
    2. NM_001320987.3NP_001307916.1  E3 ubiquitin-protein ligase TRIM37 isoform b

      Status: REVIEWED

      Source sequence(s)
      AB020705, AC099850, AC100832, AI610736, AK294850, DC343932
      Consensus CDS
      CCDS82174.1
      UniProtKB/Swiss-Prot
      O94972
      Related
      ENSP00000376784.2, ENST00000393065.6
      Conserved Domains (3) summary
      smart00502
      Location:98220
      BBC; B-Box C-terminal domain
      cd03773
      Location:239372
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:5698
      zf-B_box; B-box zinc finger
    3. NM_001320988.3NP_001307917.1  E3 ubiquitin-protein ligase TRIM37 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) and variant 5 encode the same isoform (c).
      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      cd00162
      Location:1558
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90132
      zf-B_box; B-box zinc finger
    4. NM_001320989.3NP_001307918.1  E3 ubiquitin-protein ligase TRIM37 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) and variant 4 encode the same isoform (c).
      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      cd00162
      Location:1558
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90132
      zf-B_box; B-box zinc finger
    5. NM_001320990.3NP_001307919.1  E3 ubiquitin-protein ligase TRIM37 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC100832, BX537955, DC343932
      UniProtKB/Swiss-Prot
      O94972
      Conserved Domains (2) summary
      smart00502
      Location:10132
      BBC; B-Box C-terminal domain
      cd03773
      Location:151284
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    6. NM_001353082.2NP_001340011.1  E3 ubiquitin-protein ligase TRIM37 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (4) summary
      smart00502
      Location:98220
      BBC; B-Box C-terminal domain
      smart00336
      Location:5798
      BBOX; B-Box-type zinc finger
      cd03773
      Location:239372
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cl17238
      Location:621
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    7. NM_001353083.2NP_001340012.1  E3 ubiquitin-protein ligase TRIM37 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (1) summary
      cd03773
      Location:28161
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    8. NM_001353084.2NP_001340013.1  E3 ubiquitin-protein ligase TRIM37 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      smart00336
      Location:91132
      BBOX; B-Box-type zinc finger
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd16619
      Location:1355
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
    9. NM_001353085.2NP_001340014.1  E3 ubiquitin-protein ligase TRIM37 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (2) summary
      cd03773
      Location:119252
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cl25407
      Location:1100
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    10. NM_001353086.2NP_001340015.1  E3 ubiquitin-protein ligase TRIM37 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      smart00336
      Location:91132
      BBOX; B-Box-type zinc finger
      cd03773
      Location:270389
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd16619
      Location:1355
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
    11. NM_015294.6NP_056109.1  E3 ubiquitin-protein ligase TRIM37 isoform a

      See identical proteins and their annotated locations for NP_056109.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same isoform (a).
      Source sequence(s)
      AB020705, AK289674, CN388771, DC351295
      Consensus CDS
      CCDS32694.1
      UniProtKB/Swiss-Prot
      O94972
      Related
      ENSP00000262294.7, ENST00000262294.12
      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      cd00162
      Location:1558
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90132
      zf-B_box; B-box zinc finger

    RNA

    1. NR_148346.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832
      Related
      ENST00000577554.5
    2. NR_148347.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005207, AC036154, AC099850, AC100832

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      58968010..59106880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024663.2XP_016880152.1  E3 ubiquitin-protein ligase TRIM37 isoform X4

    2. XM_017024662.1XP_016880151.1  E3 ubiquitin-protein ligase TRIM37 isoform X2

    3. XM_005257385.1XP_005257442.1  E3 ubiquitin-protein ligase TRIM37 isoform X6

      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      smart00336
      Location:91132
      BBOX; B-Box-type zinc finger
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd16619
      Location:1355
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
    4. XM_017024667.1XP_016880156.1  E3 ubiquitin-protein ligase TRIM37 isoform X11

      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      smart00336
      Location:91132
      BBOX; B-Box-type zinc finger
      cd03773
      Location:270389
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cd16619
      Location:1355
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
    5. XM_011524832.2XP_011523134.1  E3 ubiquitin-protein ligase TRIM37 isoform X3

      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      cd00162
      Location:1558
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90132
      zf-B_box; B-box zinc finger
    6. XM_024450765.1XP_024306533.1  E3 ubiquitin-protein ligase TRIM37 isoform X14

      Conserved Domains (2) summary
      cd03773
      Location:119252
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cl25407
      Location:1100
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    7. XM_017024665.1XP_016880154.1  E3 ubiquitin-protein ligase TRIM37 isoform X9

    8. XM_011524833.1XP_011523135.1  E3 ubiquitin-protein ligase TRIM37 isoform X5

      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      cd00162
      Location:1558
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:270389
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90132
      zf-B_box; B-box zinc finger
    9. XM_011524836.1XP_011523138.1  E3 ubiquitin-protein ligase TRIM37 isoform X10

      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      cd00162
      Location:1558
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90132
      zf-B_box; B-box zinc finger
    10. XM_011524831.1XP_011523133.1  E3 ubiquitin-protein ligase TRIM37 isoform X1

      Conserved Domains (4) summary
      smart00502
      Location:132254
      BBC; B-Box C-terminal domain
      cd00162
      Location:1558
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90132
      zf-B_box; B-box zinc finger
    11. XM_011524834.1XP_011523136.1  E3 ubiquitin-protein ligase TRIM37 isoform X7

      Conserved Domains (3) summary
      smart00502
      Location:98220
      BBC; B-Box C-terminal domain
      cd03773
      Location:239372
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:5698
      zf-B_box; B-box zinc finger
    12. XM_017024673.2XP_016880162.1  E3 ubiquitin-protein ligase TRIM37 isoform X17

    13. XM_017024671.2XP_016880160.1  E3 ubiquitin-protein ligase TRIM37 isoform X15

      Conserved Domains (2) summary
      cd03773
      Location:119252
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      cl25407
      Location:1100
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    14. XM_017024664.1XP_016880153.1  E3 ubiquitin-protein ligase TRIM37 isoform X8

    15. XM_017024669.2XP_016880158.1  E3 ubiquitin-protein ligase TRIM37 isoform X12

    16. XM_017024672.1XP_016880161.1  E3 ubiquitin-protein ligase TRIM37 isoform X16

    17. XM_017024670.2XP_016880159.1  E3 ubiquitin-protein ligase TRIM37 isoform X13

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