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Trim37 tripartite motif-containing 37 [ Mus musculus (house mouse) ]

Gene ID: 68729, updated on 8-Feb-2024

Summary

Official Symbol
Trim37provided by MGI
Official Full Name
tripartite motif-containing 37provided by MGI
Primary source
MGI:MGI:2153072
See related
Ensembl:ENSMUSG00000018548 AllianceGenome:MGI:2153072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MUL; TEF3; 1110032A10Rik; 2810004E07Rik
Summary
The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which is typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. In mouse this protein is proposed to oligomerize through its coiled coil domain and has been reported to be expressed in neural crest-derived tissues as well as in tissues whose development is regulated by mesenchymal-epithelial interactions. In humans, mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder characterized by prenatal onset growth failure, cardiomyopathy and dysmorphic features. [provided by RefSeq, Jan 2013]
Expression
Biased expression in cortex adult (RPKM 34.0), testis adult (RPKM 33.1) and 14 other tissues See more
Orthologs
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Genomic context

See Trim37 in Genome Data Viewer
Location:
11 C; 11 51.93 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87017675..87141700)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87126790..87250874)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E26 Neighboring gene proline rich 11 Neighboring gene microRNA 301 Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_30287 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87059058-87059211 Neighboring gene protein phosphatase 1E (PP2C domain containing) Neighboring gene predicted gene, 33937 Neighboring gene predicted gene, 22883 Neighboring gene STARR-positive B cell enhancer ABC_E3005 Neighboring gene RAD51 paralog C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • mKIAA0898

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H2AK119 ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tumor necrosis factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aggresome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of protein import into peroxisome matrix ISO
Inferred from Sequence Orthology
more info
 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in aggresome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM37
Names
RING-type E3 ubiquitin transferase TRIM37
TRAF encompassing factor 3
tripartite motif-containing protein 37
NP_001349954.1
NP_001349955.1
NP_001349956.1
NP_001349957.1
NP_932104.1
XP_006534135.1
XP_011247512.1
XP_011247514.1
XP_036012827.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363025.1NP_001349954.1  E3 ubiquitin-protein ligase TRIM37 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL596130, AL713917, BX000355
    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    smart00336
    Location:91132
    BBOX; B-Box-type zinc finger
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd16619
    Location:1355
    mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
  2. NM_001363026.1NP_001349955.1  E3 ubiquitin-protein ligase TRIM37 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL596130, AL713917, BX000355
    Conserved Domains (3) summary
    smart00502
    Location:117239
    BBC; B-Box C-terminal domain
    smart00336
    Location:76117
    BBOX; B-Box-type zinc finger
    cd03773
    Location:258391
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
  3. NM_001363027.1NP_001349956.1  E3 ubiquitin-protein ligase TRIM37 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL596130, AL713917, BX000355
    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    smart00336
    Location:91132
    BBOX; B-Box-type zinc finger
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd16619
    Location:1355
    mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
  4. NM_001363028.1NP_001349957.1  E3 ubiquitin-protein ligase TRIM37 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL596130, AL713917, BX000355
    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    smart00336
    Location:91132
    BBOX; B-Box-type zinc finger
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd16619
    Location:1355
    mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
  5. NM_197987.2NP_932104.1  E3 ubiquitin-protein ligase TRIM37 isoform 2

    See identical proteins and their annotated locations for NP_932104.1

    Status: REVIEWED

    Source sequence(s)
    AK140822, BC058678, BY457310
    Consensus CDS
    CCDS25210.1
    UniProtKB/Swiss-Prot
    Q5SX31, Q6PCX9, Q8CHC5
    Related
    ENSMUSP00000049057.7, ENSMUST00000041282.13
    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    cd00162
    Location:1558
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90132
    zf-B_box; B-box zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    87017675..87141700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249212.4XP_011247514.1  E3 ubiquitin-protein ligase TRIM37 isoform X2

    See identical proteins and their annotated locations for XP_011247514.1

    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd16619
    Location:1355
    mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
    cd19779
    Location:93132
    Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
  2. XM_006534072.4XP_006534135.1  E3 ubiquitin-protein ligase TRIM37 isoform X2

    See identical proteins and their annotated locations for XP_006534135.1

    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd16619
    Location:1355
    mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
    cd19779
    Location:93132
    Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
  3. XM_011249210.3XP_011247512.1  E3 ubiquitin-protein ligase TRIM37 isoform X1

    See identical proteins and their annotated locations for XP_011247512.1

    Conserved Domains (3) summary
    smart00502
    Location:117239
    BBC; B-Box C-terminal domain
    cd03773
    Location:258391
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd19779
    Location:78117
    Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
  4. XM_036156934.1XP_036012827.1  E3 ubiquitin-protein ligase TRIM37 isoform X3

    Conserved Domains (3) summary
    smart00502
    Location:117239
    BBC; B-Box C-terminal domain
    cd03773
    Location:258391
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd19779
    Location:78117
    Bbox2_TRIM37_C-VIII; B-box-type 2 zinc finger found in tripartite motif-containing protein 37 (TRIM37) and similar proteins