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    LYN LYN proto-oncogene, Src family tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 4067, updated on 2-May-2024

    Summary

    Official Symbol
    LYNprovided by HGNC
    Official Full Name
    LYN proto-oncogene, Src family tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:6735
    See related
    Ensembl:ENSG00000254087 MIM:165120; AllianceGenome:HGNC:6735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JTK8; SAIDV; p53Lyn; p56Lyn
    Summary
    This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
    Expression
    Broad expression in spleen (RPKM 32.6), appendix (RPKM 29.7) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    8q12.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (55879835..56014169)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (56256887..56391325)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (56792394..56926728)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 265 Neighboring gene transmembrane protein 68 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:56684839-56685342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27376 Neighboring gene trimethylguanosine synthase 1 Neighboring gene MPRA-validated peak7024 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27377 Neighboring gene Sharpr-MPRA regulatory region 11739 Neighboring gene Sharpr-MPRA regulatory region 4705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27379 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27383 Neighboring gene Sharpr-MPRA regulatory region 4485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:56826630-56827130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:56827131-56827631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27387 Neighboring gene Sharpr-MPRA regulatory region 838 Neighboring gene small nucleolar RNA, H/ACA box 1B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27388 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:56843083-56843621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:56852106-56852621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:56892491-56892991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:56893036-56893536 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:56897215-56897411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27396 Neighboring gene RNA, 7SL, cytoplasmic 798, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19209 Neighboring gene RNA, 7SL, cytoplasmic 323, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr8:56960415-56960946 Neighboring gene proteasome 26S subunit, ATPase, 6 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Autoinflammatory disease, systemic, with vasculitis
    MedGen: C5830525 OMIM: 620376 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.
    EBI GWAS Catalog
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn PubMed
    env Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production PubMed
    env Stimulation of human monocyte-derived macrophages with HIV-1 gp120 results in the CCR5-mediated activation of Lyn and the concomitant Lyn-dependent activation of the mitogen-activated protein (MAP) kinase ERK-1/2, which leads to production of TNF-alpha PubMed
    Nef nef The primary M-group HIV-1 Nef proteins (from A, B, C, F, G, H, J, and K subtypes) strongly activate LYN in cells PubMed
    nef Interaction of HIV-1 Nef with the SH3 domain of Lyn regulates its effects on Lyn tyrosine kinase activation PubMed
    nef The interaction of HIV-1 Nef with Lyn does not induce Lyn kinase activation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ26625

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glycosphingolipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables phosphatidylinositol 3-kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphorylation-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables platelet-derived growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in C-X-C chemokine receptor CXCR4 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA damage checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Fc receptor mediated inhibitory signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Fc receptor mediated stimulatory signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Fc receptor mediated stimulatory signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    involved_in T cell costimulation TAS
    Traceable Author Statement
    more info
     
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to retinoic acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendritic cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dendritic cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in eosinophil differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT TAS
    Traceable Author Statement
    more info
     
    involved_in hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histamine secretion by mast cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response-regulating cell surface receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in immune response-regulating cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in interleukin-5-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in leukocyte migration TAS
    Traceable Author Statement
    more info
     
    involved_in lipopolysaccharide-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of inflammatory response to antigenic stimulus TAS
    Traceable Author Statement
    more info
     
    involved_in negative regulation of intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of mast cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of myeloid leukocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of toll-like receptor 2 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of toll-like receptor 4 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oligodendrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendritic cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mast cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of oligodendrocyte progenitor proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of B cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mast cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mast cell degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of monocyte chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of platelet aggregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amino acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to axon injury IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to carbohydrate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to sterol depletion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in tolerance induction to self antigen IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tolerance induction to self antigen ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tolerance induction to self antigen TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in toll-like receptor 4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of integrin alpha2-beta1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lysosomal membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrial crista IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic specialization, intracellular component IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase Lyn
    Names
    lck/Yes-related novel protein tyrosine kinase
    v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    NP_001104567.1
    NP_002341.1
    XP_011515831.2
    XP_054216452.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029593.1 RefSeqGene

      Range
      5009..139343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001111097.3NP_001104567.1  tyrosine-protein kinase Lyn isoform B

      See identical proteins and their annotated locations for NP_001104567.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame donor splice site in the 5' coding region compared to variant 1. This results in a shorter isoform (B) missing an internal protein segment compared to isoform A.
      Source sequence(s)
      AC046176, BC068551, BG059526, BU954348, DA948647
      Consensus CDS
      CCDS47859.1
      UniProtKB/TrEMBL
      A8K379
      Related
      ENSP00000428424.1, ENST00000520220.6
      Conserved Domains (3) summary
      cd10364
      Location:104204
      SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
      cd12004
      Location:46101
      SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
      cd05072
      Location:218489
      PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn
    2. NM_002350.4NP_002341.1  tyrosine-protein kinase Lyn isoform A

      See identical proteins and their annotated locations for NP_002341.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (A).
      Source sequence(s)
      AC046176, AK290494, BC068551, BG059526, BU954348, CB990993, DA948647
      Consensus CDS
      CCDS6162.1
      UniProtKB/Swiss-Prot
      A0AVQ5, P07948
      UniProtKB/TrEMBL
      A8K379
      Related
      ENSP00000428924.1, ENST00000519728.6
      Conserved Domains (3) summary
      cd10364
      Location:125225
      SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
      cd12004
      Location:67122
      SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
      cd05072
      Location:239510
      PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      55879835..56014169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517529.4XP_011515831.2  tyrosine-protein kinase Lyn isoform X1

      UniProtKB/TrEMBL
      B4DQ79

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      56256887..56391325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360477.1XP_054216452.1  tyrosine-protein kinase Lyn isoform X1

      UniProtKB/TrEMBL
      B4DQ79