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Lyn LYN proto-oncogene, Src family tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 17096, updated on 12-Feb-2024

Summary

Official Symbol
Lynprovided by MGI
Official Full Name
LYN proto-oncogene, Src family tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:96892
See related
Ensembl:ENSMUSG00000042228 AllianceGenome:MGI:96892
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hck-2; p53Lyn; p56Lyn
Summary
Enables SH3 domain binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including immune response-regulating signaling pathway; immune system development; and regulation of signal transduction. Acts upstream of or within several processes, including B cell receptor signaling pathway; peptidyl-tyrosine phosphorylation; and regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including membrane raft; nucleus; and plasma membrane. Part of protein-containing complex. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Used to study systemic lupus erythematosus. Orthologous to human LYN (LYN proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 46.2), lung adult (RPKM 24.2) and 23 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See Lyn in Genome Data Viewer
Location:
4 A1; 4 2.05 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (3676865..3791613)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (3678068..3791612)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene trimethylguanosine synthase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4609 Neighboring gene STARR-positive B cell enhancer mm9_chr4:3574269-3574569 Neighboring gene STARR-positive B cell enhancer ABC_E6150 Neighboring gene RIKEN cDNA 2210414B05 gene Neighboring gene STARR-seq mESC enhancer starr_09415 Neighboring gene predicted gene, 42250 Neighboring gene RIKEN cDNA 6330407A03 gene Neighboring gene STARR-positive B cell enhancer mm9_chr4:3651863-3652164 Neighboring gene STARR-seq mESC enhancer starr_09416 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6152 Neighboring gene STARR-seq mESC enhancer starr_09419 Neighboring gene predicted gene, 22781 Neighboring gene STARR-seq mESC enhancer starr_09421 Neighboring gene STARR-seq mESC enhancer starr_09423 Neighboring gene predicted gene, 24016 Neighboring gene ribosomal protein S20

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables erythropoietin receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables glycosphingolipid binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables non-membrane spanning protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphorylation-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within B cell receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in C-X-C chemokine receptor CXCR4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in Fc receptor mediated inhibitory signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Fc receptor mediated stimulatory signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Fc receptor mediated stimulatory signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eosinophil differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in hemoglobin biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histamine secretion by mast cell ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response-regulating cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-5-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mast cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of mast cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of myeloid leukocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of toll-like receptor 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet degranulation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in platelet degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendritic cell apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of dendritic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mast cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oligodendrocyte progenitor proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress-activated protein kinase signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of B cell apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of B cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mast cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mast cell degranulation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hormone IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in tolerance induction to self antigen IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tolerance induction to self antigen IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alpha2-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial crista ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic specialization, intracellular component ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase Lyn
Names
V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
NP_001104566.1
NP_034877.2
XP_036019675.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111096.2NP_001104566.1  tyrosine-protein kinase Lyn isoform A

    See identical proteins and their annotated locations for NP_001104566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A).
    Source sequence(s)
    AL772401
    Consensus CDS
    CCDS51109.1
    UniProtKB/Swiss-Prot
    P25911, Q62127
    UniProtKB/TrEMBL
    Q3TCS3, Q8CEI0
    Related
    ENSMUSP00000038838.7, ENSMUST00000041377.13
    Conserved Domains (4) summary
    cd10364
    Location:125225
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:67122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:239510
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn
    pfam07714
    Location:247497
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_010747.3NP_034877.2  tyrosine-protein kinase Lyn isoform B

    See identical proteins and their annotated locations for NP_034877.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform B).
    Source sequence(s)
    AL772401
    Consensus CDS
    CCDS17939.1
    UniProtKB/TrEMBL
    Q3U6Q5, Q8CEI0
    Related
    ENSMUSP00000100075.4, ENSMUST00000103010.4
    Conserved Domains (4) summary
    cd10364
    Location:104204
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:46101
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:218489
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn
    pfam07714
    Location:226476
    Pkinase_Tyr; Protein tyrosine kinase

RNA

  1. NR_185264.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772401

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    3676865..3791613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163782.1XP_036019675.1  tyrosine-protein kinase Lyn isoform X2

    Conserved Domains (3) summary
    cd12004
    Location:67122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cl15255
    Location:125225
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:235263
    PKc_like; Protein Kinases, catalytic domain