U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Luc7l3 LUC7-like 3 pre-mRNA splicing factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360602, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Luc7l3provided by RGD
    Official Full Name
    LUC7-like 3 pre-mRNA splicing factorprovided by RGD
    Primary source
    RGD:1307981
    See related
    Ensembl:ENSRNOG00000002835 AllianceGenome:RGD:1307981
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crop; RGD1307981
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site selection. Predicted to be located in nuclear speck. Predicted to be part of U1 snRNP and U2-type prespliceosome. Orthologous to human LUC7L3 (LUC7 like 3 pre-mRNA splicing factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 458.1), Spleen (RPKM 324.7) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    10q26
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (79737457..79773478, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (79240050..79276555, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (81991147..82027119, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 Neighboring gene ANKRD40 C-terminal like Neighboring gene uncharacterized LOC134480857 Neighboring gene ankyrin repeat domain 40 Neighboring gene ATP binding cassette subfamily C member 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line. Nishii Y, et al. FEBS Lett, 2000 Jan 14. PMID 10631324
    2. Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. Umehara H, et al. Biochem Biophys Res Commun, 2003 Feb 7. PMID 12565863
    3. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    luc7-like protein 3
    Names
    cisplatin resistance-associated overexpressed protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108291.1 → NP_001101761.1  luc7-like protein 3

      See identical proteins and their annotated locations for NP_001101761.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I5ZVZ0, A6HI41, D3ZFB2
      Related
      ENSRNOP00000003914.4, ENSRNOT00000003914.7
      Conserved Domains (2) summary
      COG5200
      Location:4 → 244
      LUC7; U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]
      pfam03194
      Location:4 → 240
      LUC7; LUC7 N_terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      79737457..79773478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247155.5 → XP_006247217.1  luc7-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVZ0, A0A8I6AUY1
      Related
      ENSRNOP00000091946.1
      Conserved Domains (2) summary
      COG5200
      Location:4 → 244
      LUC7; U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]
      pfam03194
      Location:4 → 240
      LUC7; LUC7 N_terminus

    2. XM_039086386.2 → XP_038942314.1  luc7-like protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVZ0, A0A8I6AE53
      Related
      ENSRNOP00000092560.1
      Conserved Domains (1) summary
      pfam03194
      Location:4 → 246
      LUC7; LUC7 N_terminus

    3. XM_063269415.1 → XP_063125485.1  luc7-like protein 3 isoform X4

    4. XM_063269414.1 → XP_063125484.1  luc7-like protein 3 isoform X4

    5. XM_017597392.3 → XP_017452881.1  luc7-like protein 3 isoform X3

      Conserved Domains (1) summary
      pfam03194
      Location:4 → 246
      LUC7; LUC7 N_terminus

    RNA

    1. XR_005489891.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous