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LUC7L3 LUC7 like 3 pre-mRNA splicing factor [ Homo sapiens (human) ]

Gene ID: 51747, updated on 12-Oct-2019

Summary

Official Symbol
LUC7L3provided by HGNC
Official Full Name
LUC7 like 3 pre-mRNA splicing factorprovided by HGNC
Primary source
HGNC:HGNC:24309
See related
Ensembl:ENSG00000108848 MIM:609434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRA; CROP; LUC7A; hLuc7A; CREAP-1; OA48-18
Summary
This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]
Expression
Ubiquitous expression in endometrium (RPKM 53.0), ovary (RPKM 46.4) and 25 other tissues See more
Orthologs

Genomic context

See LUC7L3 in Genome Data Viewer
Location:
17q21.33
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (50719565..50756219)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48796926..48830072)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily C member 3 Neighboring gene ABCC3 (B) eExon liver enhancer Neighboring gene ankyrin repeat domain 40 Neighboring gene ANKRD40 C-terminal like Neighboring gene microRNA 8059

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA splice site selection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
luc7-like protein 3
Names
CRE-associated protein 1
LUC7-like 3
cAMP regulatory element-associated protein 1
cisplatin resistance-associated-overexpressed protein
okadaic acid-inducible phosphoprotein OA48-18

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330330.2NP_001317259.1  luc7-like protein 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC005921, AK225980, BC047043, DA218563
    Consensus CDS
    CCDS82158.1
    UniProtKB/TrEMBL
    J3KPP4, Q86Y74
    Related
    ENSP00000376919.2, ENST00000393227.6
    Conserved Domains (1) summary
    pfam03194
    Location:4244
    LUC7; LUC7 N_terminus
  2. NM_006107.3NP_006098.2  luc7-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_006098.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal region in the 3' UTR, as compared to variant 1.
    Source sequence(s)
    AC005921, AK023672, CN271700, DA231851
    Consensus CDS
    CCDS11573.1
    UniProtKB/Swiss-Prot
    O95232
    Related
    ENSP00000240304.1, ENST00000240304.5
    Conserved Domains (1) summary
    pfam03194
    Location:4244
    LUC7; LUC7 N_terminus
  3. NM_016424.5NP_057508.2  luc7-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_057508.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC005921, AK290540, BC047043, CN271700, DA231851
    Consensus CDS
    CCDS11573.1
    UniProtKB/Swiss-Prot
    O95232
    UniProtKB/TrEMBL
    A8K3C5, Q86Y74
    Related
    ENSP00000425092.1, ENST00000505658.6
    Conserved Domains (1) summary
    pfam03194
    Location:4244
    LUC7; LUC7 N_terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    50719565..50756219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450799.1XP_024306567.1  luc7-like protein 3 isoform X4

    Conserved Domains (1) summary
    pfam03194
    Location:2168
    LUC7; LUC7 N_terminus
  2. XM_024450798.1XP_024306566.1  luc7-like protein 3 isoform X3

    Conserved Domains (1) summary
    pfam03194
    Location:2168
    LUC7; LUC7 N_terminus
  3. XM_005257449.2XP_005257506.1  luc7-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005257506.1

    Conserved Domains (1) summary
    pfam03194
    Location:4244
    LUC7; LUC7 N_terminus
  4. XM_005257452.1XP_005257509.1  luc7-like protein 3 isoform X2

    See identical proteins and their annotated locations for XP_005257509.1

    Conserved Domains (1) summary
    pfam03194
    Location:4244
    LUC7; LUC7 N_terminus
  5. XM_024450800.1XP_024306568.1  luc7-like protein 3 isoform X5

    Conserved Domains (1) summary
    cl27291
    Location:2168
    LUC7; LUC7 N_terminus
  6. XM_006721943.2XP_006722006.1  luc7-like protein 3 isoform X3

    See identical proteins and their annotated locations for XP_006722006.1

    Conserved Domains (1) summary
    pfam03194
    Location:2168
    LUC7; LUC7 N_terminus

RNA

  1. XR_002958022.1 RNA Sequence

  2. XR_001752531.1 RNA Sequence

  3. XR_001752527.1 RNA Sequence

  4. XR_001752528.1 RNA Sequence

  5. XR_001752529.1 RNA Sequence

  6. XR_001752530.1 RNA Sequence

  7. XR_001752532.1 RNA Sequence

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