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    FAS Fas cell surface death receptor [ Homo sapiens (human) ]

    Gene ID: 355, updated on 19-Jul-2021

    Summary

    Official Symbol
    FASprovided by HGNC
    Official Full Name
    Fas cell surface death receptorprovided by HGNC
    Primary source
    HGNC:HGNC:11920
    See related
    Ensembl:ENSG00000026103 MIM:134637
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
    Summary
    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
    Annotation information
    Note: FAS (Gene ID: 355) and FASN (Gene ID: 2194) share the FAS symbol/alias in common. FAS is a widely used alternative name for fatty acid synthase (FASN), which can be confused with the official symbol for FAS (Fas cell surface death receptor, GeneID 355). [01 Jun 2018]
    Expression
    Ubiquitous expression in colon (RPKM 4.3), lymph node (RPKM 4.0) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FAS in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (88968429..89017059)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90750555..90776816)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379869 Neighboring gene ACTA2 antisense RNA 1 Neighboring gene actin alpha 2, smooth muscle Neighboring gene FAS antisense RNA 1 Neighboring gene microRNA 4679-2 Neighboring gene microRNA 4679-1 Neighboring gene zinc finger RNA binding protein pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    GeneReviews: Not available
    Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
    GeneReviews: Not available
    Autoimmune lymphoproliferative syndrome Compare labs
    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
    GeneReviews: Not available
    Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science.
    GeneReviews: Not available
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 binds and signals through CD4, which leads to T cell activation with upregulation of the CXCR5, PD-1, Fas, and FasL expression PubMed
    env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
    env Binding of HIV-1 gp120 to CD4 downregulates Bcl-2 protein in CD4+ T lymphocytes and facilitates Fas/Fas-ligand triggered apoptosis; addition of IL-2 rescues CD4+ T cells from CD4/gp120-induced Bcl-2 down modulation and apoptosis induction PubMed
    env Apoptosis induced by HIV-1 gp120/CD4 cross-linking in Th1 clones is inhibited by anti-CD95 or anti-CD95L neutralizing monoclonal antibodies, as well as by a specific interleukin-1 beta converting enzyme (ICE) inhibitor PubMed
    env HIV-1 gp120-induced neuron apoptosis requires the upregulation of the death receptor Fas and its associated death proteins, FADD and CASP8 PubMed
    env At high concentrations, HIV-1 gp120 enhances expression of Fas and FasL and promotes apoptosis in human mesangial cells (HMC) PubMed
    env HIV-1 gp120-mediated CD4 engagement is involved in the induction of susceptibility of primary human T lymphocytes to CD95-mediated apoptosis through ezrin phosphorylation and ezrin-to-CD95 association PubMed
    env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed
    env CXCR4-tropic and CXCR4/CCR5 dual-tropic HIV-1 gp120 induce the relocalization of cytoplasmic CD95 to the cellular plasma membrane and a 23% increase in CD95-mediated apoptosis PubMed
    env Preincubation of T cells with HIV-1 gp120 accelerates the apoptosis observed during CD2-pathway stimulation of the T cells; this process is mediated by Fas/Fas ligand interaction and related to an increased induction of Fas ligand mRNA by gp120 PubMed
    env Antibodies reactive to a domain within the V3 region of HIV-1 gp120 are effective cross-linkers of Fas and increase apoptosis in peripheral T cells PubMed
    Envelope surface glycoprotein gp160, precursor env The calmodulin-binding domains in HIV-1 gp160 are involved in Fas-mediated apoptosis PubMed
    Nef nef HIV-1 Nef specifically incorporates CSF2, PPBP (NAP2), CCL5, TNF, FAS, CXCL1, IL12B, MIF and OSM into plasma extracellular vesicles from HIV-1 infected patient samples PubMed
    nef HIV-1 Nef sensitizes CD4+ T lymphoid cells to apoptosis by upregulating the expression of both Fas and Fas ligand, an effect that requires the PxxP motif (amino acids 72-75) in the core region of Nef PubMed
    nef Amino acid 106 of HIV-1 Nef is important for the inhibition of Fas-mediated apoptosis resulting from the interaction of Nef with ASK1 PubMed
    nef HIV-1 Nef inhibits Fas-mediated apoptosis by binding to and inactivating the catalytic activity of ASK1, as well as through the downregulation of caspase-3 and caspase-8 PubMed
    nef In a murine model of AIDS, CD4C/HIV transgenic (Tg) mice expressing HIV-1 Nef, it has been shown that Nef upregulates expression of Fas and FasL in CD4+ and CD8+ cells from the Tg mouse PubMed
    Tat tat HIV-1 Tat sensitizes T cells to CD95 mediated apoptosis through the upregulation of CD95 ligand and caspase 8 PubMed
    tat HIV-1 Tat activates B and T cells and upregulates expression of Fas (CD95) in these cells PubMed
    Vpr vpr Virion-associated Vpr activates caspase 3/7, 8, and 9 in Fas-mediated apoptosis in Jurkat T cells and human activated PBMCs PubMed
    Vpu vpu Increased susceptibility of HIV-infected cells to Fas killing has been mapped to the HIV-1 vpu gene PubMed
    integrase gag-pol IL-7 and CD95 synergistically promote survival and proliferation of HIV-1-latently infected CD4+ T-cells measured by increased levels of integrated HIV-1 DNA, suggesting that HIV-1 IN interacts with IL-7 and CD95 in latently infected CD4+ T-cells PubMed
    matrix gag HIV-1 MA increases FAS mRNA expression in HepG2 cells and primary hepatocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables tumor necrosis factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Fas signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation-induced cell death of T cells IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hyperoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in motor neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in necroptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in necroptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-containing complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of stress-activated MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of CD95 death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 6
    Names
    APO-1 cell surface antigen
    CD95 antigen
    FASLG receptor
    Fas (TNF receptor superfamily, member 6)
    Fas AMA
    TNF receptor superfamily member 6
    apoptosis antigen 1
    apoptosis signaling receptor FAS
    apoptosis-mediating surface antigen FAS
    mutant tumor necrosis receptor superfamily member 6
    tumor necrosis factor receptor superfamily, member 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009089.2 RefSeqGene

      Range
      5001..30255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_134

    mRNA and Protein(s)

    1. NM_000043.6NP_000034.1  tumor necrosis factor receptor superfamily member 6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000034.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK026195, AK290978, AL157394, BC012479, BU620333
      Consensus CDS
      CCDS7393.1
      UniProtKB/Swiss-Prot
      P25445
      Related
      ENSP00000498466.1, ENST00000652046.1
      Conserved Domains (2) summary
      cd08316
      Location:226319
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:39167
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
    2. NM_001320619.2NP_001307548.1  tumor necrosis factor receptor superfamily member 6 isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate exon in the 3' coding region resulting in a frameshift compared to variant 1. The encoded isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, FJ200481
      UniProtKB/Swiss-Prot
      P25445
      UniProtKB/TrEMBL
      K9J972
      Related
      ENSP00000347979.3, ENST00000355740.7
      Conserved Domains (1) summary
      cd10579
      Location:39167
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
    3. NM_152871.4NP_690610.1  tumor necrosis factor receptor superfamily member 6 isoform 2 precursor

      See identical proteins and their annotated locations for NP_690610.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as FasdeltaTM or soluble FAS, lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal region, compared to isoform 1.
      Source sequence(s)
      AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, Z47993
      Consensus CDS
      CCDS7394.1
      UniProtKB/Swiss-Prot
      P25445
      Related
      ENSP00000349896.2, ENST00000357339.6
      Conserved Domains (2) summary
      cd08316
      Location:205298
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:39167
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
    4. NM_152872.4NP_690611.1  tumor necrosis factor receptor superfamily member 6 isoform 3 precursor

      See identical proteins and their annotated locations for NP_690611.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as FASExo8Del, lacks a coding segment, which leads to a translation frameshift, compared to variant 1. The resulting isoform (3) contains a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK026195, AL157394, BC012479, BU620333, DA699562, Z66556
      Consensus CDS
      CCDS7395.1
      UniProtKB/Swiss-Prot
      P25445
      Related
      ENSP00000347426.2, ENST00000355279.2
      Conserved Domains (1) summary
      cd10579
      Location:39167
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

    RNA

    1. NR_028033.4 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate coding exons compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and likely is not translated.
      Source sequence(s)
      AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, Z70520
    2. NR_028034.4 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks three alternate exons compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and likely is not translated.
      Source sequence(s)
      AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, Z47995
    3. NR_028035.4 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and likely is not translated.
      Source sequence(s)
      AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, Z47994
    4. NR_028036.4 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an alternate coding exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and likely is not translated.
      Source sequence(s)
      AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, Z70519
    5. NR_135313.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AK026195, AK290978, AL157394, BC012479, BU620333, DA699562, X83492
    6. NR_135314.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AK026195, AK290978, AK311424, AL157394, BC012479, BU620333, DA040126
    7. NR_135315.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AK026195, AK290978, AK311424, AL157394, AV715411, BC012479, BU620333

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      88968429..89017059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717819.3XP_006717882.1  tumor necrosis factor receptor superfamily member 6 isoform X3

      See identical proteins and their annotated locations for XP_006717882.1

      UniProtKB/TrEMBL
      Q59FU8
      Conserved Domains (2) summary
      cd08316
      Location:253346
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:66194
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
    2. XM_011539764.2XP_011538066.1  tumor necrosis factor receptor superfamily member 6 isoform X1

      Conserved Domains (2) summary
      cd08316
      Location:280373
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:93221
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
    3. XM_011539765.2XP_011538067.1  tumor necrosis factor receptor superfamily member 6 isoform X2

      Conserved Domains (2) summary
      cd08316
      Location:259352
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:93221
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
    4. XM_011539766.2XP_011538068.1  tumor necrosis factor receptor superfamily member 6 isoform X3

      See identical proteins and their annotated locations for XP_011538068.1

      UniProtKB/TrEMBL
      Q59FU8
      Conserved Domains (2) summary
      cd08316
      Location:253346
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:66194
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
    5. XM_011539767.3XP_011538069.1  tumor necrosis factor receptor superfamily member 6 isoform X4

      Conserved Domains (2) summary
      cd08316
      Location:241334
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:54182
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

    RNA

    1. XR_945733.2 RNA Sequence

    2. XR_945732.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152873.1: Suppressed sequence

      Description
      NM_152873.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_152874.1: Suppressed sequence

      Description
      NM_152874.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    3. NM_152875.1: Suppressed sequence

      Description
      NM_152875.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    4. NM_152876.1: Suppressed sequence

      Description
      NM_152876.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    5. NM_152877.1: Suppressed sequence

      Description
      NM_152877.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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