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Fas Fas (TNF receptor superfamily member 6) [ Mus musculus (house mouse) ]

Gene ID: 14102, updated on 23-Nov-2021

Summary

Official Symbol
Fasprovided by MGI
Official Full Name
Fas (TNF receptor superfamily member 6)provided by MGI
Primary source
MGI:MGI:95484
See related
Ensembl:ENSMUSG00000024778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
lpr; APO1; APT1; CD95; TNFR6; Tnfrsf6; AI196731
Expression
Broad expression in liver E18 (RPKM 4.7), bladder adult (RPKM 3.9) and 19 other tissues See more
Orthologs
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Genomic context

See Fas in Genome Data Viewer
Location:
19 C1; 19 29.48 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34267926..34305175)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34290647..34327775)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (34365149..34402260)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene actin alpha 2, smooth muscle, aorta Neighboring gene predicted gene, 31355 Neighboring gene cholesterol 25-hydroxylase Neighboring gene lysosomal acid lipase A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables tumor necrosis factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tumor necrosis factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Fas signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation-induced cell death of T cells IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within activation-induced cell death of T cells IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hyperoxia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to lithium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in dendrite regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hepatocyte apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inflammatory cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within inflammatory cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lymphocyte apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in motor neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in necroptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within necroptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in necroptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of B cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Schwann cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Schwann cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of release of cytochrome c from mitochondria IC
Inferred by Curator
more info
PubMed 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of lymphocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to glucocorticoid IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CD95 death-inducing signaling complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of CD95 death-inducing signaling complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of CD95 death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 6
Names
FASLG receptor
Fas (TNF receptor superfamily member)
Fas antigen
apo-1 antigen
apoptosis-mediating surface antigen FAS
lymphoproliferation

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146708.1NP_001140180.1  tumor necrosis factor receptor superfamily member 6 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001140180.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 3' end, compared to variant 1. These differences produce a unique 3' UTR and a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK086933, BY348234
    Consensus CDS
    CCDS50420.1
    UniProtKB/TrEMBL
    Q8C350
    Related
    ENSMUSP00000108091.3, ENSMUST00000112472.4
    Conserved Domains (1) summary
    cl22855
    Location:3561
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  2. NM_007987.2NP_032013.2  tumor necrosis factor receptor superfamily member 6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032013.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC061160, BY348234
    Consensus CDS
    CCDS29758.1
    UniProtKB/Swiss-Prot
    P25446
    Related
    ENSMUSP00000025691.6, ENSMUST00000025691.13
    Conserved Domains (2) summary
    cd08316
    Location:218309
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd10579
    Location:35163
    TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    34267926..34305175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250746.2XP_030106606.1  tumor necrosis factor receptor superfamily member 6 isoform X1

    Conserved Domains (3) summary
    cd08316
    Location:193284
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd00185
    Location:5698
    TNFRSF; CRD2 [structural motif]
    cl22855
    Location:38138
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  2. XM_030250747.2XP_030106607.1  tumor necrosis factor receptor superfamily member 6 isoform X1

    Conserved Domains (3) summary
    cd08316
    Location:193284
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd00185
    Location:5698
    TNFRSF; CRD2 [structural motif]
    cl22855
    Location:38138
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  3. XM_030250749.2XP_030106609.1  tumor necrosis factor receptor superfamily member 6 isoform X1

    Conserved Domains (3) summary
    cd08316
    Location:193284
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd00185
    Location:5698
    TNFRSF; CRD2 [structural motif]
    cl22855
    Location:38138
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  4. XM_030250748.2XP_030106608.1  tumor necrosis factor receptor superfamily member 6 isoform X1

    Conserved Domains (3) summary
    cd08316
    Location:193284
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd00185
    Location:5698
    TNFRSF; CRD2 [structural motif]
    cl22855
    Location:38138
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  5. XM_030250751.2XP_030106611.1  tumor necrosis factor receptor superfamily member 6 isoform X2

    Conserved Domains (3) summary
    cd08316
    Location:148239
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd00185
    Location:1153
    TNFRSF; CRD2 [structural motif]
    cl22855
    Location:193
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  6. XM_036161430.1XP_036017323.1  tumor necrosis factor receptor superfamily member 6 isoform X2

    Conserved Domains (3) summary
    cd08316
    Location:148239
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd00185
    Location:1153
    TNFRSF; CRD2 [structural motif]
    cl22855
    Location:193
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
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