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    KCNIP3 potassium voltage-gated channel interacting protein 3 [ Homo sapiens (human) ]

    Gene ID: 30818, updated on 5-Mar-2024

    Summary

    Official Symbol
    KCNIP3provided by HGNC
    Official Full Name
    potassium voltage-gated channel interacting protein 3provided by HGNC
    Primary source
    HGNC:HGNC:15523
    See related
    Ensembl:ENSG00000115041 MIM:604662; AllianceGenome:HGNC:15523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSEN; DREAM; KCHIP3
    Summary
    This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 13.6), thyroid (RPKM 9.3) and 14 other tissues See more
    Orthologs
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    Genomic context

    See KCNIP3 in Genome Data Viewer
    Location:
    2q11.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (95297347..95386077)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (95803824..95892559)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (95963095..96051825)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16184 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11741 Neighboring gene zinc finger protein 892 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:95905736-95906935 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:95930712-95930896 Neighboring gene prominin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95964228-95964728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95971889-95972774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95974547-95975430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95981486-95981986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95984379-95984880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95992523-95993090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95996289-95996790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95996791-95997290 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:96008733-96008969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96040144-96040723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96041305-96041883 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:96047731-96047930 Neighboring gene fatty acid binding protein 7 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:96051115-96052015 Neighboring gene uncharacterized LOC124907858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96063267-96063766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:96067226-96068165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:96068166-96069104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96081056-96081556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96081557-96082057 Neighboring gene fumarylacetoacetate hydrolase domain containing 2A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of Kv channel interacting protein 3, calsenilin (KCNIP3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC18289

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    calsenilin
    Names
    A-type potassium channel modulatory protein 3
    DRE-antagonist modulator
    Kv channel interacting protein 3, calsenilin
    calsenilin, presenilin-binding protein, EF hand transcription factor
    kv channel-interacting protein 3
    potassium channel interacting protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034914.2NP_001030086.1  calsenilin isoform 2

      See identical proteins and their annotated locations for NP_001030086.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame segment in the 5' coding region and uses an alternate start codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a unique N-terminus, compared to isoform 1.
      Source sequence(s)
      AC009238, BC012850, DQ148486, HY076476
      Consensus CDS
      CCDS33245.1
      UniProtKB/TrEMBL
      A0A8V8TMV8
      Related
      ENSP00000417499.1, ENST00000468529.1
      Conserved Domains (2) summary
      COG5126
      Location:55219
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:140212
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. NM_013434.5NP_038462.1  calsenilin isoform 1

      See identical proteins and their annotated locations for NP_038462.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC012850, BI755669, BX491997
      Consensus CDS
      CCDS2013.1
      UniProtKB/Swiss-Prot
      H7BY46, Q3YAC3, Q3YAC4, Q53TJ5, Q96T40, Q9UJ84, Q9UJ85, Q9Y2W7
      Related
      ENSP00000295225.5, ENST00000295225.10
      Conserved Domains (2) summary
      COG5126
      Location:81245
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:166238
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      95297347..95386077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791760.1 Reference GRCh38.p14 PATCHES

      Range
      59451..148184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      95803824..95892559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)