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    H1-6 H1.6 linker histone, cluster member [ Homo sapiens (human) ]

    Gene ID: 3010, updated on 5-May-2024

    Summary

    Official Symbol
    H1-6provided by HGNC
    Official Full Name
    H1.6 linker histone, cluster memberprovided by HGNC
    Primary source
    HGNC:HGNC:4720
    See related
    Ensembl:ENSG00000187475 MIM:142712; AllianceGenome:HGNC:4720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H1t; H1.6; H1FT; HIST1H1T; dJ221C16.2
    Summary
    Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
    Orthologs
    NEW
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    Genomic context

    See H1-6 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26107412..26108135, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (25975560..25976283, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26107640..26108363, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene HFE antisense RNA 1 Neighboring gene homeostatic iron regulator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24188 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:26103833-26104523 Neighboring gene H4 clustered histone 3 Neighboring gene H2B clustered histone 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26121574-26122260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26122261-26122945 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:26123079-26124278 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:26124310-26125509 Neighboring gene H2A clustered histone 6

    Genomic regions, transcripts, and products

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.
    EBI GWAS Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag interacts with HIST1H1T as demonstrated by proximity dependent biotinylation proteomics PubMed
    gag Tandem affinity purification and mass spectrometry analysis identify H1t associated HIV-1 Gag in 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC163222

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    histone H1t
    Names
    H1 histone family, member T (testis-specific)
    histone 1, H1t
    histone cluster 1 H1 family member t
    histone cluster 1, H1t
    testicular H1 histone

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005323.4NP_005314.2  histone H1t

      See identical proteins and their annotated locations for NP_005314.2

      Status: REVIEWED

      Source sequence(s)
      U91328
      Consensus CDS
      CCDS34349.1
      UniProtKB/Swiss-Prot
      P22492, Q6ISI1, Q8IUE8
      UniProtKB/TrEMBL
      A1L407
      Related
      ENSP00000341214.5, ENST00000338379.6
      Conserved Domains (1) summary
      cd00073
      Location:43126
      H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      26107412..26108135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      25975560..25976283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)