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H1f6 H1.6 linker histone, cluster member [ Mus musculus (house mouse) ]

Gene ID: 107970, updated on 1-Mar-2024

Summary

Official Symbol
H1f6provided by MGI
Official Full Name
H1.6 linker histone, cluster memberprovided by MGI
Primary source
MGI:MGI:1888530
See related
Ensembl:ENSMUSG00000036211 AllianceGenome:MGI:1888530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H1t; H1-6; H1.6; H1ft; Hist1h1t
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H1f6 in Genome Data Viewer
Location:
13 A3.1; 13 9.88 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23879794..23880528)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23695811..23696545)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E384 Neighboring gene STARR-positive B cell enhancer ABC_E8514 Neighboring gene H2A clustered histone 6 Neighboring gene H2B clustered histone 4 Neighboring gene H4 clustered histone 3 Neighboring gene STARR-positive B cell enhancer ABC_E7215 Neighboring gene homeostatic iron regulator

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within binding of sperm to zona pellucida IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within flagellated sperm motility IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone H1t
Names
H1 histone family, member T (testis-specific)
histone 1, H1t
histone cluster 1, H1t
testicular H1 histone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010377.3NP_034507.2  histone H1t

    See identical proteins and their annotated locations for NP_034507.2

    Status: REVIEWED

    Source sequence(s)
    AL592149
    Consensus CDS
    CCDS26358.1
    UniProtKB/TrEMBL
    I7HFT9
    Related
    ENSMUSP00000037304.3, ENSMUST00000041052.5
    Conserved Domains (1) summary
    cd00073
    Location:37117
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    23879794..23880528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)