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    LPAR1 lysophosphatidic acid receptor 1 [ Bos taurus (cattle) ]

    Gene ID: 281136, updated on 3-Apr-2024

    Summary

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    Official Symbol
    LPAR1provided by VGNC
    Official Full Name
    lysophosphatidic acid receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:30955
    See related
    Ensembl:ENSBTAG00000009654
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    EDG2
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 8
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (100350056..100518672, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Neighboring gene uncharacterized LOC132346007 Neighboring gene muscle associated receptor tyrosine kinase Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene small nucleolar RNA SNORA71 Neighboring gene uncharacterized LOC112447838 Neighboring gene microRNA mir-2285n-5 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lysophosphatidic acid stimulates prostaglandin E2 production in cultured stromal endometrial cells through LPA1 receptor. Woclawek-Potocka I, et al. Exp Biol Med (Maywood), 2009 Aug. PMID 19491366
    2. Which bovine endometrial cells are the source of and target for lysophosphatidic acid? Boruszewska D, et al. Reprod Biol, 2013 Mar. PMID 23522079
    3. Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. Macrae AD, et al. Brain Res Mol Brain Res, 1996 Dec. PMID 9013780
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. expression is lower in epithelial cells than in stromal cells of the endometrium
      Title: Which bovine endometrial cells are the source of and target for lysophosphatidic acid?
    2. Lysophosphatidic acid stimulates PGE(2) production, cell viability, and intracellular calcium ion mobilization in cultured stromal endometrial cells via Ki16425-sensitive LPA1 receptors.
      Title: Lysophosphatidic acid stimulates prostaglandin E2 production in cultured stromal endometrial cells through LPA1 receptor.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lysophosphatidic acid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysophosphatidic acid receptor 1
    Names
    LPA receptor 1
    LPA-1
    endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
    lysophosphatidic acid receptor Edg-2
    rec1.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174047.2 → NP_776472.1  lysophosphatidic acid receptor 1

      See identical proteins and their annotated locations for NP_776472.1

      Status: PROVISIONAL

      Source sequence(s)
      U48236
      UniProtKB/Swiss-Prot
      Q28031
      UniProtKB/TrEMBL
      A0A3Q1MEZ4
      Conserved Domains (1) summary
      pfam00001
      Location:67 → 311
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      100350056..100518672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010808241.4 → XP_010806543.1  lysophosphatidic acid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_010806543.1

      UniProtKB/TrEMBL
      A0A3Q1M9C6, A0A3Q1MEZ4
      Related
      ENSBTAP00000070704.1, ENSBTAT00000085678.2
      Conserved Domains (1) summary
      cd15344
      Location:50 → 322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_005210511.5 → XP_005210568.1  lysophosphatidic acid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_005210568.1

      UniProtKB/TrEMBL
      A0A3Q1M9C6, A0A3Q1MEZ4
      Conserved Domains (1) summary
      cd15344
      Location:50 → 322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_059888945.1 → XP_059744928.1  lysophosphatidic acid receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M9C6

    4. XM_005210512.5 → XP_005210569.1  lysophosphatidic acid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_005210569.1

      UniProtKB/TrEMBL
      A0A3Q1M9C6, A0A3Q1MEZ4
      Conserved Domains (1) summary
      cd15344
      Location:50 → 322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

    5. XM_005210513.5 → XP_005210570.1  lysophosphatidic acid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_005210570.1

      UniProtKB/TrEMBL
      A0A3Q1M9C6, A0A3Q1MEZ4
      Conserved Domains (1) summary
      cd15344
      Location:50 → 322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

    6. XM_024995437.2 → XP_024851205.1  lysophosphatidic acid receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M9C6, A0A3Q1MEZ4
      Conserved Domains (1) summary
      cd15344
      Location:50 → 322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28031.1 GenPept UniProtKB/Swiss-Prot:Q28031

    Gene LinkOut

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