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LPAR1 lysophosphatidic acid receptor 1 [ Homo sapiens (human) ]

Gene ID: 1902, updated on 11-Sep-2019

Summary

Official Symbol
LPAR1provided by HGNC
Official Full Name
lysophosphatidic acid receptor 1provided by HGNC
Primary source
HGNC:HGNC:3166
See related
Ensembl:ENSG00000198121 MIM:602282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDG2; LPA1; VZG1; GPR26; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3
Summary
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 14.7), placenta (RPKM 8.1) and 22 other tissues See more
Orthologs

Genomic context

See LPAR1 in Genome Data Viewer
Location:
9q31.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (110873252..111038998, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (113635542..113801523, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene muscle associated receptor tyrosine kinase Neighboring gene uncharacterized LOC107987115 Neighboring gene ribosomal protein S21 pseudogene 5 Neighboring gene RNA, U6 small nuclear 432, pseudogene Neighboring gene uncharacterized LOC105376219 Neighboring gene RNY4 pseudogene 18 Neighboring gene VISTA enhancer hs1447

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Multiple loci are associated with white blood cell phenotypes.
NHGRI GWA Catalog

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Gap junction, organism-specific biosystem (from KEGG)
    Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Gap junction, conserved biosystem (from KEGG)
    Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
    LPA receptor mediated events, organism-specific biosystem
    LPA receptor mediated events
  • Lysosphingolipid and LPA receptors, organism-specific biosystem (from REACTOME)
    Lysosphingolipid and LPA receptors, organism-specific biosystemThe Lysophospholipid receptor (LPLR) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans there are eight LPL rec...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • NOTCH1 regulation of human endothelial cell calcification, organism-specific biosystem (from WikiPathways)
    NOTCH1 regulation of human endothelial cell calcification, organism-specific biosystemModel of NOTCH1 regulation of human endothelial cell calcification.
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
    Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Small Ligand GPCRs, organism-specific biosystem (from WikiPathways)
    Small Ligand GPCRs, organism-specific biosystem
    Small Ligand GPCRs

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
G-protein alpha-subunit binding IEA
Inferred from Electronic Annotation
more info
 
PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
lysophosphatidic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
lysophosphatidic acid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
lysophosphatidic acid receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
activation of phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
bleb assembly IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to 1-oleoyl-sn-glycerol 3-phosphate IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxygen levels IEA
Inferred from Electronic Annotation
more info
 
cerebellum development IEA
Inferred from Electronic Annotation
more info
 
corpus callosum development IEA
Inferred from Electronic Annotation
more info
 
myelination IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
oligodendrocyte development IEA
Inferred from Electronic Annotation
more info
 
optic nerve development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dendritic spine development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
lysophosphatidic acid receptor 1
Names
LPA receptor 1
LPA-1
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
lysophosphatidic acid receptor Edg-2
ventricular zone gene 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351397.2NP_001338326.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, BC036034, DA479098
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001351398.2NP_001338327.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, AK290287, BC036034, DA088664, DA479098
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001351399.2NP_001338328.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, AK290287, BC036034, DA479098
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001351400.2NP_001338329.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, AK290287, BC036034, DA088664, DC327578
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_001351401.2NP_001338330.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, AK290287, BC036034, DC327578, DC340753, DC418941
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  6. NM_001351402.2NP_001338331.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, AK290287, BC036034, DC418941
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  7. NM_001351403.2NP_001338332.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, BC036034, DC327578
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  8. NM_001351404.2NP_001338333.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, BC036034, DC327578, DC340753
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  9. NM_001351405.2NP_001338334.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, BC036034, DC327578, DC422078
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  10. NM_001351406.2NP_001338335.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, BC036034, DB477196, DC325182
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  11. NM_001351407.2NP_001338336.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, AK290287, BC036034, DA088664, DB477196, DC325182
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  12. NM_001351408.2NP_001338337.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, AK290287, BC036034, DB477196, DC418941
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  13. NM_001351409.2NP_001338338.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, AK290287, BC036034, DB477196, DC340753, DC418941
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  14. NM_001351410.2NP_001338339.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, AK290287, BC036034, DB477196, DC418941, DC422078
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  15. NM_001351411.2NP_001338340.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, BC036034, DB477196, DC325182, DC340753
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  16. NM_001351412.2NP_001338341.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, BC036034, CN360217, DB477196, DC422078
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  17. NM_001351413.2NP_001338342.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, BC036034, CN360217, DB477196, DC422078
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  18. NM_001351414.2NP_001338343.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, BC036034, DB477196, DC340753, DC422078
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  19. NM_001351415.2NP_001338344.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AC007157, AI674417, AK022808, AK290287, BC036034, DA088664, DC325182, DC418941
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  20. NM_001351416.2NP_001338345.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AC007157, AI674417, AK022808, AK290287, BC036034, DC418941
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  21. NM_001351417.2NP_001338346.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AC007157, AI674417, AK022808, BC036034, DC340753
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  22. NM_001351418.2NP_001338347.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AC007157, AI674417, AK022808, BC036034, CN360217, DB477196, DC340753, DC422078
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  23. NM_001351419.1NP_001338348.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AC007157, AI674417, AK022808, BC036034, BM988491, DC340753
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  24. NM_001351420.1NP_001338349.1  lysophosphatidic acid receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AI674417, AK022808, BC036034, BM988491, DA327368
    Consensus CDS
    CCDS6777.1
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  25. NM_001401.5NP_001392.2  lysophosphatidic acid receptor 1

    See identical proteins and their annotated locations for NP_001392.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1-26 encode the same protein.
    Source sequence(s)
    AC007157, AI674417, AK022808, BC036034
    Consensus CDS
    CCDS6777.1
    UniProtKB/Swiss-Prot
    Q92633
    UniProtKB/TrEMBL
    Q5VZX0
    Related
    ENSP00000351755.4, ENST00000358883.8
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  26. NM_057159.4NP_476500.1  lysophosphatidic acid receptor 1

    See identical proteins and their annotated locations for NP_476500.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-26 encode the same protein.
    Source sequence(s)
    AC007157, AI674417, AK022808, BC030615, BC036034
    Consensus CDS
    CCDS6777.1
    UniProtKB/Swiss-Prot
    Q92633
    UniProtKB/TrEMBL
    Q5VZX0
    Related
    ENSP00000363553.3, ENST00000374431.7
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    110873252..111038998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251782.3XP_005251839.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_005251839.1

    UniProtKB/Swiss-Prot
    Q92633
    UniProtKB/TrEMBL
    Q5VZX0
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_017014404.2XP_016869893.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q92633
    UniProtKB/TrEMBL
    Q5VZX0
    Related
    ENSP00000363552.1, ENST00000374430.6
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
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