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Lpar1 lysophosphatidic acid receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 14745, updated on 5-Jan-2023

Summary

Official Symbol
Lpar1provided by MGI
Official Full Name
lysophosphatidic acid receptor 1provided by MGI
Primary source
MGI:MGI:108429
See related
Ensembl:ENSMUSG00000038668 AllianceGenome:MGI:108429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Edg2; Kdt2; lpA1; vzg-1; Gpcr26
Summary
Enables PDZ domain binding activity and lysophosphatidic acid receptor activity. Involved in several processes, including activation of phospholipase C activity; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and positive regulation of stress fiber assembly. Acts upstream of or within bleb assembly; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 20.9), colon adult (RPKM 17.1) and 24 other tissues See more
Orthologs
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Genomic context

See Lpar1 in Genome Data Viewer
Location:
4 B3; 4 32.2 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (58435252..58554601, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (58435252..58554027, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30907 Neighboring gene muscle, skeletal, receptor tyrosine kinase Neighboring gene microRNA 3095 Neighboring gene arginine/serine-rich coiled-coil 2 pseudogene Neighboring gene predicted gene, 54282 Neighboring gene predicted gene 12579 Neighboring gene olfactory receptor family 2 subfamily K member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29102, 5031439C20

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lysophosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables lysophosphatidic acid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysophosphatidic acid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lysophosphatidic acid receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within bleb assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to 1-oleoyl-sn-glycerol 3-phosphate ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lysophosphatidic acid receptor 1
Names
G-protein coupled receptor 26
LPA receptor 1
endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2
lysophosphatidic acid receptor Edg-2
rec1.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290486.1NP_001277415.1  lysophosphatidic acid receptor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 2. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK030330, AL807748, BY126445, U48235
    Consensus CDS
    CCDS71391.1
    UniProtKB/Swiss-Prot
    P61793
    UniProtKB/TrEMBL
    A0A6P5PLF5, Q544V2
    Related
    ENSMUSP00000103196.2, ENSMUST00000107570.2
    Conserved Domains (1) summary
    cd15344
    Location:32304
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_010336.2NP_034466.2  lysophosphatidic acid receptor 1 isoform 1

    See identical proteins and their annotated locations for NP_034466.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK030330, AL807748, CJ152526
    Consensus CDS
    CCDS18212.1
    UniProtKB/Swiss-Prot
    P61793, Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Related
    ENSMUSP00000103201.3, ENSMUST00000107575.9
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_172989.1NP_766577.1  lysophosphatidic acid receptor 1 isoform 1

    See identical proteins and their annotated locations for NP_766577.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK030330, AL807748, BY716867, CJ175997
    Consensus CDS
    CCDS18212.1
    UniProtKB/Swiss-Prot
    P61793, Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Related
    ENSMUSP00000052581.5, ENSMUST00000055018.11
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    58435252..58554601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249931.4XP_011248233.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011248233.1

    UniProtKB/Swiss-Prot
    P61793, Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_030253215.2XP_030109075.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_011249929.3XP_011248231.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011248231.1

    UniProtKB/Swiss-Prot
    P61793, Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_011249932.4XP_011248234.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011248234.1

    UniProtKB/Swiss-Prot
    P61793, Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_030253214.2XP_030109074.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  6. XM_011249928.4XP_011248230.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011248230.1

    UniProtKB/Swiss-Prot
    P61793, Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  7. XM_036163687.1XP_036019580.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  8. XM_036163685.1XP_036019578.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  9. XM_011249930.3XP_011248232.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011248232.1

    UniProtKB/Swiss-Prot
    P61793, Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  10. XM_011249933.4XP_011248235.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011248235.1

    UniProtKB/Swiss-Prot
    P61793, Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  11. XM_011249934.3XP_011248236.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011248236.1

    UniProtKB/Swiss-Prot
    P61793, Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  12. XM_036163686.1XP_036019579.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q61130
    UniProtKB/TrEMBL
    A0A6P7QUC5, A0A8C6HKP9, Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors