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    STK39 serine/threonine kinase 39 [ Homo sapiens (human) ]

    Gene ID: 27347, updated on 11-Apr-2024

    Summary

    Official Symbol
    STK39provided by HGNC
    Official Full Name
    serine/threonine kinase 39provided by HGNC
    Primary source
    HGNC:HGNC:17717
    See related
    Ensembl:ENSG00000198648 MIM:607648; AllianceGenome:HGNC:17717
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCHT; PASK; SPAK
    Summary
    This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 10.6), esophagus (RPKM 7.1) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    2q24.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (167954022..168247595, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (168411922..168705066, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (168810532..169104105, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene beta-1,3-galactosyltransferase 1 Neighboring gene CTAGE family member 14, pseudogene Neighboring gene B3GALT1 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:168700657-168701624 Neighboring gene NANOG hESC enhancer GRCh37_chr2:168718058-168718586 Neighboring gene uncharacterized LOC124907903 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:168801351-168802550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16730 Neighboring gene NANOG hESC enhancer GRCh37_chr2:168920562-168921101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12071 Neighboring gene NANOG hESC enhancer GRCh37_chr2:168972872-168973411 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:169067330-169068529 Neighboring gene uncharacterized LOC124906088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12073 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12074 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12076 Neighboring gene uncharacterized LOC107985959 Neighboring gene PHF5A pseudogene 5 Neighboring gene uncharacterized LOC105373734 Neighboring gene NANOG hESC enhancer GRCh37_chr2:169211617-169212118

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.
    EBI GWAS Catalog
    Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
    EBI GWAS Catalog
    Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686K05124

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular hyperosmotic response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular hypotonic response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to chemokine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to potassium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemokine (C-X-C motif) ligand 12 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular chloride ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macrophage activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of lens transparency ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of creatine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of pancreatic juice secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of potassium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of potassium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of sodium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of T cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of T cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in renal sodium ion absorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to aldosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to dietary excess IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    STE20/SPS1-related proline-alanine-rich protein kinase
    Names
    STE20/SPS1 homolog
    Ste20-like protein kinase
    proline-alanine-rich STE20-related kinase
    serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
    serine/threonine-protein kinase 39
    small intestine SPAK-like kinase
    ste-20-related kinase
    NP_001397890.1
    NP_037365.2
    XP_016859302.1
    XP_016859303.1
    XP_016859305.1
    XP_016859306.1
    XP_047299897.1
    XP_047299900.1
    XP_054197366.1
    XP_054197367.1
    XP_054197368.1
    XP_054197369.1
    XP_054197370.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052783.1 RefSeqGene

      Range
      5001..298574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001410961.1NP_001397890.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC016723, AC017069, AC067940
      Consensus CDS
      CCDS92893.1
      UniProtKB/TrEMBL
      A0A8V8TKT5
      Related
      ENSP00000513185.1, ENST00000697205.1
    2. NM_013233.3NP_037365.2  STE20/SPS1-related proline-alanine-rich protein kinase isoform 1

      See identical proteins and their annotated locations for NP_037365.2

      Status: REVIEWED

      Source sequence(s)
      AC016723, AF099989, BF516344
      Consensus CDS
      CCDS42770.1
      UniProtKB/Swiss-Prot
      O14774, Q53S90, Q53SL7, Q53SS1, Q9UER4, Q9UEW8, X5D9C8
      UniProtKB/TrEMBL
      X5D2U3
      Related
      ENSP00000348278.4, ENST00000355999.5
      Conserved Domains (2) summary
      smart00220
      Location:63337
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06610
      Location:61337
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      167954022..168247595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443944.1XP_047299900.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X4

    2. XM_017003817.3XP_016859306.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X6

    3. XM_047443941.1XP_047299897.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X2

    4. XM_017003813.3XP_016859302.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X1

      UniProtKB/TrEMBL
      X5D2U3
    5. XM_017003814.3XP_016859303.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X3

      UniProtKB/TrEMBL
      X5D2U3
    6. XM_017003816.3XP_016859305.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      168411922..168705066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341395.1XP_054197370.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X6

    2. XM_054341392.1XP_054197367.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X2

    3. XM_054341391.1XP_054197366.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X1

    4. XM_054341393.1XP_054197368.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X3

    5. XM_054341394.1XP_054197369.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X5