STK39 serine/threonine kinase 39 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STK39provided by HGNC
Official Full Name: serine/threonine kinase 39provided by HGNC
Primary source: HGNC:HGNC:17717
See related: Ensembl:ENSG00000198648 MIM:607648; AllianceGenome:HGNC:17717
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DCHT; PASK; SPAK
Summary: This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 10.6), esophagus (RPKM 7.1) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q24.3

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (167954022..168247595, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (168411922..168705066, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (168810532..169104105, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircSTK39 suppresses the proliferation and invasion of bladder cancer by regulating the miR-135a-5p/NR3C2-mediated epithelial-mesenchymal transition signaling pathway.
Title: CircSTK39 suppresses the proliferation and invasion of bladder cancer by regulating the miR-135a-5p/NR3C2-mediated epithelial-mesenchymal transition signaling pathway.
Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.
Title: Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.
Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38.
Title: Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38.
Transcription factor specificity protein 1-mediated Serine/threonine kinase 39 upregulation promotes the proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells by activating the transforming growth factor-beta1 /Smad2/3 pathway.
Title: Transcription factor specificity protein 1-mediated Serine/threonine kinase 39 upregulation promotes the proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells by activating the transforming growth factor-β1 /Smad2/3 pathway.
Knockdown of long non-coding RNA CDKN2B-AS1 suppresses the progression of breast cancer by miR-122-5p/STK39 axis.
Title: Knockdown of long non-coding RNA CDKN2B-AS1 suppresses the progression of breast cancer by miR-122-5p/STK39 axis.
Variant rs6749447 (T > G) in the serine threonine kinase gene is associated with cardiovascular complications, the Tampere adult population cardiovascular risk study.
Title: Variant rs6749447 (T > G) in the serine threonine kinase gene is associated with cardiovascular complications, the Tampere adult population cardiovascular risk study.
STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation.
Title: STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation.
SPAK and OSR1 kinases bind and phosphorylate the beta2-Adrenergic receptor.
Title: SPAK and OSR1 kinases bind and phosphorylate the β(2)-Adrenergic receptor.
The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.
Title: The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.
Identification and characterization of alternative STK39 transcripts within human and mouse kidneys reveals species-specific regulation of blood pressure.
Title: Identification and characterization of alternative STK39 transcripts within human and mouse kidneys reveals species-specific regulation of blood pressure.

Submit: New GeneRIF Correction See all GeneRIFs (73)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. EBI GWAS Catalog EBI GWAS CatalogPubMed
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH11654 (e-PCR)
- UniSTS:58134

SHGC-144147 (e-PCR)
- UniSTS:183322

NoName (e-PCR)
- UniSTS:482333

SHGC-145855 (e-PCR)
- UniSTS:183340

RH68427 (e-PCR)
- UniSTS:31029

SHGC-104962 (e-PCR)
- UniSTS:169043

SHGC-149406 (e-PCR)
- UniSTS:176986

SHGC-32064 (e-PCR)
- UniSTS:74882

D16S325 (e-PCR)
- UniSTS:147089

26 (e-PCR), detects polymorphism
- UniSTS:26515

RH99072 (e-PCR)
- UniSTS:85155

SHGC-70162 (e-PCR)
- UniSTS:183471

RH69463 (e-PCR)
- UniSTS:41429

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell volume homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular hyperosmotic response	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular hyperosmotic response	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular hypotonic response	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to chemokine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to potassium ion	IEA Inferred from Electronic Annotation more info
involved_in chemokine (C-X-C motif) ligand 12 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in intracellular chloride ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage activation	IEA Inferred from Electronic Annotation more info
involved_in maintenance of lens transparency	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of creatine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of pancreatic juice secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of potassium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of sodium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-threonine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in renal sodium ion absorption	IDA Inferred from Direct Assay more info	PubMed
involved_in response to aldosterone	IEA Inferred from Electronic Annotation more info
involved_in response to dietary excess	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell body	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: STE20/SPS1-related proline-alanine-rich protein kinase

Names: STE20/SPS1 homolog; Ste20-like protein kinase; proline-alanine-rich STE20-related kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); serine/threonine-protein kinase 39; small intestine SPAK-like kinase; ste-20-related kinase

NP_001397890.1

EC 2.7.11.1

NP_037365.2

EC 2.7.11.1

XP_016859302.1

EC 2.7.11.1

XP_016859303.1

EC 2.7.11.1

XP_016859305.1

EC 2.7.11.1

XP_016859306.1

EC 2.7.11.1

XP_047299897.1

EC 2.7.11.1

XP_047299900.1

EC 2.7.11.1

XP_054197366.1

EC 2.7.11.1

XP_054197367.1

EC 2.7.11.1

XP_054197368.1

EC 2.7.11.1

XP_054197369.1

EC 2.7.11.1

XP_054197370.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052783.1 RefSeqGene

Range

5001..298574

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001410961.1 → NP_001397890.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform 2

Status: REVIEWED

Source sequence(s)

AC016723, AC017069, AC067940

Consensus CDS

CCDS92893.1

UniProtKB/TrEMBL

A0A8V8TKT5

Related

ENSP00000513185.1, ENST00000697205.1
NM_013233.3 → NP_037365.2 STE20/SPS1-related proline-alanine-rich protein kinase isoform 1

See identical proteins and their annotated locations for NP_037365.2

Status: REVIEWED

Source sequence(s)

AC016723, AF099989, BF516344

Consensus CDS

CCDS42770.1

UniProtKB/Swiss-Prot

O14774, Q53S90, Q53SL7, Q53SS1, Q9UER4, Q9UEW8, X5D9C8

UniProtKB/TrEMBL

X5D2U3

Related

ENSP00000348278.4, ENST00000355999.5

Conserved Domains (2) summary

smart00220
Location:63 → 337

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06610
Location:61 → 337

STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

167954022..168247595 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047443944.1 → XP_047299900.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X4
XM_017003817.3 → XP_016859306.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X6
XM_047443941.1 → XP_047299897.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X2
XM_017003813.3 → XP_016859302.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X1

UniProtKB/TrEMBL

X5D2U3
XM_017003814.3 → XP_016859303.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X3

UniProtKB/TrEMBL

X5D2U3
XM_017003816.3 → XP_016859305.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X5

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

168411922..168705066 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054341395.1 → XP_054197370.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X6
XM_054341392.1 → XP_054197367.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X2
XM_054341391.1 → XP_054197366.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X1
XM_054341393.1 → XP_054197368.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X3
XM_054341394.1 → XP_054197369.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform X5