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Stk39 serine/threonine kinase 39 [ Mus musculus (house mouse) ]

Gene ID: 53416, updated on 8-Feb-2024

Summary

Official Symbol
Stk39provided by MGI
Official Full Name
serine/threonine kinase 39provided by MGI
Primary source
MGI:MGI:1858416
See related
Ensembl:ENSMUSG00000027030 AllianceGenome:MGI:1858416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DCHT; Rnl5; SPAK; RF005; Gm50618
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including cellular hypotonic response; negative regulation of transport; and protein phosphorylation. Acts upstream of or within several processes, including negative regulation of potassium ion transmembrane transport; negative regulation of protein phosphorylation; and regulation of inflammatory response. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in brain and metanephros. Used to study Gitelman syndrome and pseudohypoaldosteronism. Orthologous to human STK39 (serine/threonine kinase 39). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 29.2), cerebellum adult (RPKM 12.7) and 19 other tissues See more
Orthologs
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Genomic context

See Stk39 in Genome Data Viewer
Location:
2; 2 C1.3
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (68040789..68302381, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (68210445..68472108, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 Neighboring gene predicted gene, 54157 Neighboring gene STARR-seq mESC enhancer starr_04706 Neighboring gene actin-like 6A pseudogene Neighboring gene STARR-seq mESC enhancer starr_04707 Neighboring gene STARR-seq mESC enhancer starr_04708 Neighboring gene STARR-seq mESC enhancer starr_04709 Neighboring gene STARR-seq mESC enhancer starr_04712 Neighboring gene predicted gene, 54158 Neighboring gene predicted gene 13596 Neighboring gene Tax1 (human T-cell leukemia virus type I) binding protein 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular hyperosmotic response ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular hypotonic response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular hypotonic response ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to potassium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chemokine (C-X-C motif) ligand 12 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular chloride ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of lens transparency IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of creatine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of pancreatic juice secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of potassium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of potassium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of potassium ion transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-threonine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of p38MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in renal sodium ion absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in response to aldosterone IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to dietary excess IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
STE20/SPS1-related proline-alanine-rich protein kinase
Names
Ste-20 related kinase
kidney-specific SPAK
serine/threonine kinase 39, STE20/SPS1 homolog
serine/threonine-protein kinase 39
ste-20-related kinase
NP_001399473.1
NP_001399474.1
NP_001399475.1
NP_001399476.1
NP_001408409.1
NP_001408410.1
NP_058562.1
XP_017174617.1
XP_017174618.1
XP_017174619.1
XP_030107738.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412544.1NP_001399473.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL844841, AL845486
  2. NM_001412545.1NP_001399474.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL844841, AL845486, BX936296
  3. NM_001412546.1NP_001399475.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL844841, AL845486, BX936296
  4. NM_001412547.1NP_001399476.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL844841, AL845486, BX936296
  5. NM_001421480.1NP_001408409.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL844841, AL845486
  6. NM_001421481.1NP_001408410.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL845486, BX936296
  7. NM_016866.3NP_058562.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform 1

    See identical proteins and their annotated locations for NP_058562.1

    Status: VALIDATED

    Source sequence(s)
    AL844841, AL845486, BX936296
    Consensus CDS
    CCDS16084.1
    UniProtKB/Swiss-Prot
    Q80W13, Q9Z1W9
    UniProtKB/TrEMBL
    A2AQL0
    Related
    ENSMUSP00000099776.4, ENSMUST00000102715.4
    Conserved Domains (2) summary
    smart00220
    Location:75349
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:73349
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RNA

  1. NR_178213.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL844841, AL845486, BX936296

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    68040789..68302381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319130.2XP_017174619.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X4

    Conserved Domains (2) summary
    cd06610
    Location:11277
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
    pfam12202
    Location:391448
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
  2. XM_017319129.1XP_017174618.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X2

    Conserved Domains (2) summary
    cd06610
    Location:5271
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
    pfam12202
    Location:364421
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
  3. XM_017319128.1XP_017174617.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X1

    Conserved Domains (2) summary
    cd06610
    Location:5271
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
    pfam12202
    Location:385442
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
  4. XM_030251878.2XP_030107738.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X5

    UniProtKB/TrEMBL
    G1JLS7, Q3V256
    Conserved Domains (2) summary
    pfam12202
    Location:213270
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    cl21453
    Location:199
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_003953672.1 RNA Sequence

  2. XR_001783147.1 RNA Sequence