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Stk39 serine/threonine kinase 39 [ Mus musculus (house mouse) ]

Gene ID: 53416, updated on 3-Oct-2018

Summary

Official Symbol
Stk39provided by MGI
Official Full Name
serine/threonine kinase 39provided by MGI
Primary source
MGI:MGI:1858416
See related
Ensembl:ENSMUSG00000027030 Vega:OTTMUSG00000012975
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DCHT; Rnl5; SPAK; RF005; AW227544; AW556857
Expression
Broad expression in testis adult (RPKM 29.2), cerebellum adult (RPKM 12.7) and 19 other tissues See more
Orthologs

Genomic context

See Stk39 in Genome Data Viewer
Location:
2; 2 C1.3
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (68210445..68471981, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (68048504..68310038, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 Neighboring gene microRNA 6335 Neighboring gene actin-like 6A pseudogene Neighboring gene uncharacterized LOC108168764 Neighboring gene predicted gene 13596 Neighboring gene Tax1 (human T-cell leukemia virus type I) binding protein 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Chemically induced (ENU) (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinase activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular hypotonic response IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
 
chemokine (C-X-C motif) ligand 12 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of lens transparency IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of creatine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pancreatic juice secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of potassium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of potassium ion transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction by protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
signal transduction by trans-phosphorylation ISO
Inferred from Sequence Orthology
more info
 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
STE20/SPS1-related proline-alanine-rich protein kinase
Names
Ste-20 related kinase
kidney-specific SPAK
serine/threonine kinase 39, STE20/SPS1 homolog
serine/threonine-protein kinase 39
ste-20-related kinase
NP_058562.1
XP_011237995.1
XP_017174617.1
XP_017174618.1
XP_017174619.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016866.2NP_058562.1  STE20/SPS1-related proline-alanine-rich protein kinase

    See identical proteins and their annotated locations for NP_058562.1

    Status: PROVISIONAL

    Source sequence(s)
    BC064443
    Consensus CDS
    CCDS16084.1
    UniProtKB/Swiss-Prot
    Q9Z1W9
    UniProtKB/TrEMBL
    A2AQL0
    Related
    ENSMUSP00000099776.3, OTTMUSP00000013981, ENSMUST00000102715.3, OTTMUST00000031247
    Conserved Domains (2) summary
    smart00220
    Location:75349
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:73349
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    68210445..68471981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319129.1XP_017174618.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X2

  2. XM_017319128.1XP_017174617.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X1

  3. XM_017319130.1XP_017174619.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X3

  4. XM_011239693.2XP_011237995.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X4

    Conserved Domains (2) summary
    pfam12202
    Location:245276
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl21453
    Location:2131
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001783147.1 RNA Sequence

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