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STK39 serine/threonine kinase 39 [ Homo sapiens (human) ]

Gene ID: 27347, updated on 21-Dec-2019

Summary

Official Symbol
STK39provided by HGNC
Official Full Name
serine/threonine kinase 39provided by HGNC
Primary source
HGNC:HGNC:17717
See related
Ensembl:ENSG00000198648 MIM:607648
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCHT; PASK; SPAK
Summary
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 10.6), esophagus (RPKM 7.1) and 23 other tissues See more
Orthologs

Genomic context

See STK39 in Genome Data Viewer
Location:
2q24.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (167954020..168247595, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (168810530..169104105, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene beta-1,3-galactosyltransferase 1 Neighboring gene CTAGE family member 14, pseudogene Neighboring gene B3GALT1 antisense RNA 1 Neighboring gene uncharacterized LOC107985959 Neighboring gene PHD finger protein 5G pseudogene Neighboring gene uncharacterized LOC105373733

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.
NHGRI GWA Catalog
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
NHGRI GWA Catalog
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686K05124

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular hypotonic response IC
Inferred by Curator
more info
PubMed 
cellular response to chemokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemokine (C-X-C motif) ligand 12 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
maintenance of lens transparency ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of creatine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of pancreatic juice secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of potassium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of sodium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction by protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction by trans-phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
STE20/SPS1-related proline-alanine-rich protein kinase
Names
STE20/SPS1 homolog
Ste20-like protein kinase
proline-alanine-rich STE20-related kinase
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
serine/threonine-protein kinase 39
small intestine SPAK-like kinase
ste-20-related kinase
NP_037365.2
XP_005246522.1
XP_016859302.1
XP_016859303.1
XP_016859304.1
XP_016859305.1
XP_016859306.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052783.1 RefSeqGene

    Range
    5001..298574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_013233.3NP_037365.2  STE20/SPS1-related proline-alanine-rich protein kinase

    See identical proteins and their annotated locations for NP_037365.2

    Status: REVIEWED

    Source sequence(s)
    AC016723, AF099989, BF516344
    Consensus CDS
    CCDS42770.1
    UniProtKB/Swiss-Prot
    Q9UEW8
    Related
    ENSP00000348278.4, ENST00000355999.5
    Conserved Domains (2) summary
    smart00220
    Location:63337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:61337
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    167954020..168247595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246465.2XP_005246522.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:63337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06610
    Location:61337
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
  2. XM_017003815.2XP_016859304.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X4

  3. XM_017003817.2XP_016859306.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X6

  4. XM_017003813.2XP_016859302.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X1

  5. XM_017003814.2XP_016859303.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X3

  6. XM_017003816.2XP_016859305.1  STE20/SPS1-related proline-alanine-rich protein kinase isoform X5

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