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    PABPC1 poly(A) binding protein cytoplasmic 1 [ Homo sapiens (human) ]

    Gene ID: 26986, updated on 5-May-2024

    Summary

    Official Symbol
    PABPC1provided by HGNC
    Official Full Name
    poly(A) binding protein cytoplasmic 1provided by HGNC
    Primary source
    HGNC:HGNC:8554
    See related
    Ensembl:ENSG00000070756 MIM:604679; AllianceGenome:HGNC:8554
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAB1; PABP; PABP1; PABPC2; PABPL1
    Summary
    This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in esophagus (RPKM 345.6), urinary bladder (RPKM 280.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    Location:
    8q22.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (100702916..100722088, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (101828977..101848145, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (101715144..101734316, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene sorting nexin 31 Neighboring gene uncharacterized LOC105375672 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:101679632-101680242 Neighboring gene RNA, U6 small nuclear 1092, pseudogene Neighboring gene microRNA 7705 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:101733555-101734387 Neighboring gene H3K27ac hESC enhancers GRCh37_chr8:101734442-101734942 and GRCh37_chr8:101734943-101735443 Neighboring gene RNA, U6atac small nuclear 41, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr8:101768155-101768656 Neighboring gene ribosomal protein S20 pseudogene 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify cytoplasmic unit 1 of polyA binding protein (PABPC1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify cytoplasmic unit 1 of polyA binding protein (PABPC1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify cytoplasmic unit 1 of polyA binding protein (PABPC1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify cytoplasmic unit 1 of polyA binding protein (PABPC1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, poly(A) binding protein 1 (PABPC1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PABPC1 is increased by RRE PubMed
    rev binding of PAB1 to HIV-1 mRNA requires the presence of Rev and results in polyadenylation of the mRNA which is necessary for the Rev-dependent nucleocytoplasmic transport of HIV-1 mRNA PubMed
    Tat tat Poly(A) binding protein, cytoplasmic 1 (PABPC1) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    retropepsin gag-pol HIV-1 PR-induced PABP cleavage is involved in the inhibition of poly(A)-dependent translation. However, PABP cleavage has little impact on the translation of polyadenylated encephalomyocarditis virus internal ribosome entry site-containing mRNAs PubMed
    gag-pol Purified HIV-1 protease cleaves poly(A)-binding protein 1 (PABP1) directly at positions 237 and 477, separating the two first RNA-recognition motifs from the C-terminal domain of PABP PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables poly(A) binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables poly(A) binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    part_of mCRD-mediated mRNA stability complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in membrane HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polyadenylate-binding protein 1
    Names
    poly(A) binding protein, cytoplasmic 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027520.1 RefSeqGene

      Range
      5000..24172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002568.4NP_002559.2  polyadenylate-binding protein 1

      See identical proteins and their annotated locations for NP_002559.2

      Status: REVIEWED

      Source sequence(s)
      AK130523, AL135187, AP001205
      Consensus CDS
      CCDS6289.1
      UniProtKB/Swiss-Prot
      P11940, Q15097, Q93004
      UniProtKB/TrEMBL
      B3KT93
      Related
      ENSP00000313007.5, ENST00000318607.10
      Conserved Domains (1) summary
      TIGR01628
      Location:11615
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      100702916..100722088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005250861.4XP_005250918.1  polyadenylate-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005250918.1

      UniProtKB/Swiss-Prot
      P11940, Q15097, Q93004
      UniProtKB/TrEMBL
      B3KT93
      Related
      ENSP00000503058.1, ENST00000679197.1
      Conserved Domains (1) summary
      TIGR01628
      Location:11615
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    2. XM_047421694.1XP_047277650.1  polyadenylate-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P11940, Q15097, Q93004
      Related
      ENSP00000429892.2, ENST00000523555.6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      101828977..101848145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360291.1XP_054216266.1  polyadenylate-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P11940, Q15097, Q93004
    2. XM_054360292.1XP_054216267.1  polyadenylate-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P11940, Q15097, Q93004