U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pabpc1 poly(A) binding protein, cytoplasmic 1 [ Mus musculus (house mouse) ]

Gene ID: 18458, updated on 5-Jan-2023

Summary

Official Symbol
Pabpc1provided by MGI
Official Full Name
poly(A) binding protein, cytoplasmic 1provided by MGI
Primary source
MGI:MGI:1349722
See related
Ensembl:ENSMUSG00000022283 AllianceGenome:MGI:1349722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PABP; ePAB; Pabp1; PabpI; Pabpl1
Summary
Predicted to enable RNA binding activity and protein C-terminus binding activity. Involved in gene silencing by RNA; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Located in cytoplasm and synapse. Is expressed in several structures, including central nervous system; early conceptus; gonad; gut; and sensory organ. Orthologous to several human genes including PABPC1 (poly(A) binding protein cytoplasmic 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 573.3), spleen adult (RPKM 194.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pabpc1 in Genome Data Viewer
Location:
15; 15 B3.1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (36595902..36609825, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (36595658..36609581, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 46 Neighboring gene sorting nexin 31 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene Neighboring gene predicted gene, 41296

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
part_of mCRD-mediated mRNA stability complex ISO
Inferred from Sequence Orthology
more info
 
part_of messenger ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polyadenylate-binding protein 1
Names
PABP-1
poly(A)-binding protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008774.3NP_032800.2  polyadenylate-binding protein 1

    See identical proteins and their annotated locations for NP_032800.2

    Status: VALIDATED

    Source sequence(s)
    AK133196, CF553208
    Consensus CDS
    CCDS27431.1
    UniProtKB/Swiss-Prot
    P29341, Q99L36
    UniProtKB/TrEMBL
    A0A8C6H9D5
    Related
    ENSMUSP00000001809.9, ENSMUST00000001809.15
    Conserved Domains (1) summary
    TIGR01628
    Location:11615
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    36595902..36609825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245339.4XP_011243641.1  polyadenylate-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011243641.1

    UniProtKB/Swiss-Prot
    P29341, Q99L36
    UniProtKB/TrEMBL
    A0A8C6H9D5
    Conserved Domains (1) summary
    TIGR01628
    Location:11615
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family