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PABPC1 poly(A) binding protein cytoplasmic 1 [ Homo sapiens (human) ]

Gene ID: 26986, updated on 4-Oct-2020

Summary

Official Symbol
PABPC1provided by HGNC
Official Full Name
poly(A) binding protein cytoplasmic 1provided by HGNC
Primary source
HGNC:HGNC:8554
See related
Ensembl:ENSG00000070756 MIM:604679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAB1; PABP; PABP1; PABPC2; PABPL1
Summary
This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in esophagus (RPKM 345.6), urinary bladder (RPKM 280.1) and 25 other tissues See more
Orthologs

Genomic context

See PABPC1 in Genome Data Viewer
Location:
8q22.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (100702916..100722088, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (101715144..101734969, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375672 Neighboring gene RNA, U6 small nuclear 1092, pseudogene Neighboring gene microRNA 7705 Neighboring gene uncharacterized LOC105375673 Neighboring gene RNA, U6atac small nuclear 41, pseudogene Neighboring gene ribosomal protein S20 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify cytoplasmic unit 1 of polyA binding protein (PABPC1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify cytoplasmic unit 1 of polyA binding protein (PABPC1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify cytoplasmic unit 1 of polyA binding protein (PABPC1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify cytoplasmic unit 1 of polyA binding protein (PABPC1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, poly(A) binding protein 1 (PABPC1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PABPC1 is increased by RRE PubMed
rev binding of PAB1 to HIV-1 mRNA requires the presence of Rev and results in polyadenylation of the mRNA which is necessary for the Rev-dependent nucleocytoplasmic transport of HIV-1 mRNA PubMed
Tat tat Poly(A) binding protein, cytoplasmic 1 (PABPC1) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
retropepsin gag-pol HIV-1 PR-induced PABP cleavage is involved in the inhibition of poly(A)-dependent translation. However, PABP cleavage has little impact on the translation of polyadenylated encephalomyocarditis virus internal ribosome entry site-containing mRNAs PubMed
gag-pol Purified HIV-1 protease cleaves poly(A)-binding protein 1 (PABP1) directly at positions 237 and 477, separating the two first RNA-recognition motifs from the C-terminal domain of PABP PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
poly(A) binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) binding TAS
Traceable Author Statement
more info
PubMed 
poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
poly(U) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation activator activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polyadenylate-binding protein 1
Names
poly(A) binding protein, cytoplasmic 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027520.1 RefSeqGene

    Range
    5000..24172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002568.4NP_002559.2  polyadenylate-binding protein 1

    See identical proteins and their annotated locations for NP_002559.2

    Status: REVIEWED

    Source sequence(s)
    AK130523, AL135187, AP001205
    Consensus CDS
    CCDS6289.1
    UniProtKB/Swiss-Prot
    P11940
    UniProtKB/TrEMBL
    A0A024R9C1
    Related
    ENSP00000313007.5, ENST00000318607.10
    Conserved Domains (1) summary
    TIGR01628
    Location:11615
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    100702916..100722088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250861.3XP_005250918.1  polyadenylate-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005250918.1

    UniProtKB/Swiss-Prot
    P11940
    UniProtKB/TrEMBL
    A0A024R9C1
    Conserved Domains (1) summary
    TIGR01628
    Location:11615
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
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