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    Shprh SNF2 histone linker PHD RING helicase [ Mus musculus (house mouse) ]

    Gene ID: 268281, updated on 5-Aug-2018

    Summary

    Official Symbol
    Shprhprovided by MGI
    Official Full Name
    SNF2 histone linker PHD RING helicaseprovided by MGI
    Primary source
    MGI:MGI:1917581
    See related
    Ensembl:ENSMUSG00000090112 Vega:OTTMUSG00000034163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA450458; AU024614; BC006883; E130018M05; 2610103K11Rik; D230017O13Rik
    Expression
    Broad expression in cerebellum adult (RPKM 3.8), CNS E18 (RPKM 3.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See Shprh in Genome Data Viewer
    Location:
    10; 10 A1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (11149319..11217595)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (10869228..10935072)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene RIKEN cDNA 4930567K20 gene Neighboring gene glutamate receptor, metabotropic 1 Neighboring gene F-box protein 30 Neighboring gene ribosomal protein L17, pseudogene 11 Neighboring gene epilepsy, progressive myoclonic epilepsy, type 2 gene alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase SHPRH
    Names
    RING-type E3 ubiquitin transferase SHPRH
    SNF2, histone-linker, PHD and RING finger domain-containing helicase
    NP_001071175.1
    NP_001271283.1
    NP_766525.3
    XP_006512803.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077707.1NP_001071175.1  E3 ubiquitin-protein ligase SHPRH isoform a

      See identical proteins and their annotated locations for NP_001071175.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK082160, BB650602, BC055003, BP757728
      Consensus CDS
      CCDS35838.1
      UniProtKB/Swiss-Prot
      Q7TPQ3
      Related
      ENSMUSP00000039422.6, OTTMUSP00000046890, ENSMUST00000044053.12, OTTMUST00000086593
      Conserved Domains (7) summary
      COG0553
      Location:13141669
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:14231473
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15547
      Location:651697
      PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
      pfam00176
      Location:707978
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:15041613
      Helicase_C; Helicase conserved C-terminal domain
      pfam00538
      Location:435506
      Linker_histone; linker histone H1 and H5 family
      pfam13424
      Location:10111095
      TPR_12; Tetratricopeptide repeat
    2. NM_001284354.1NP_001271283.1  E3 ubiquitin-protein ligase SHPRH isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform c which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK044720, AK053448, BB650602, BC055003
      Consensus CDS
      CCDS70003.1
      UniProtKB/Swiss-Prot
      Q7TPQ3
      Related
      ENSMUSP00000132870.1, OTTMUSP00000051850, ENSMUST00000159541.7, OTTMUST00000086597
      Conserved Domains (7) summary
      COG0553
      Location:13141619
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:14231473
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15547
      Location:651697
      PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
      pfam00176
      Location:707978
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:15041613
      Helicase_C; Helicase conserved C-terminal domain
      pfam00538
      Location:435506
      Linker_histone; linker histone H1 and H5 family
      pfam13424
      Location:10111095
      TPR_12; Tetratricopeptide repeat
    3. NM_172937.3NP_766525.3  E3 ubiquitin-protein ligase SHPRH isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two exons and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a distinct 3' UTR compared to variant 1. It encodes isoform b which is truncated at the C-terminus, compared to isoform a.
      Source sequence(s)
      AC158601, AK044720, AK082160, BB650602, BC055003
      Consensus CDS
      CCDS35839.1
      UniProtKB/Swiss-Prot
      Q7TPQ3
      Related
      ENSMUSP00000125849.1, OTTMUSP00000051849, ENSMUST00000054814.13, OTTMUST00000086596
      Conserved Domains (7) summary
      COG0553
      Location:13141616
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:14231473
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15547
      Location:651697
      PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
      pfam00176
      Location:707978
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:15041613
      Helicase_C; Helicase conserved C-terminal domain
      pfam00538
      Location:435506
      Linker_histone; linker histone H1 and H5 family
      pfam13424
      Location:10111095
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      11149319..11217595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512740.3XP_006512803.1  E3 ubiquitin-protein ligase SHPRH isoform X1

      See identical proteins and their annotated locations for XP_006512803.1

      UniProtKB/Swiss-Prot
      Q7TPQ3
      Conserved Domains (7) summary
      COG0553
      Location:13141669
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00162
      Location:14231473
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15547
      Location:651697
      PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
      pfam00176
      Location:707978
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:15041613
      Helicase_C; Helicase conserved C-terminal domain
      pfam00538
      Location:435506
      Linker_histone; linker histone H1 and H5 family
      pfam13424
      Location:10111095
      TPR_12; Tetratricopeptide repeat

    RNA

    1. XR_380065.3 RNA Sequence

      Related
      ENSMUST00000159810.7, OTTMUST00000086594
    2. XR_871438.2 RNA Sequence

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