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SHPRH SNF2 histone linker PHD RING helicase [ Homo sapiens (human) ]

Gene ID: 257218, updated on 19-Jun-2019

Summary

Official Symbol
SHPRHprovided by HGNC
Official Full Name
SNF2 histone linker PHD RING helicaseprovided by HGNC
Primary source
HGNC:HGNC:19336
See related
Ensembl:ENSG00000146414 MIM:608048
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bA545I5.2
Summary
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in ovary (RPKM 1.7), thyroid (RPKM 1.5) and 25 other tissues See more
Orthologs

Genomic context

See SHPRH in Genome Data Viewer
Location:
6q24.3
Exon count:
37
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (145857838..145964358, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (146205943..146285421, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene EPM2A glucan phosphatase, laforin Neighboring gene zinc finger protein 131 pseudogene Neighboring gene uncharacterized LOC100507557 Neighboring gene uncharacterized LOC105378039 Neighboring gene F-box protein 30 Neighboring gene glutamate metabotropic receptor 1 Neighboring gene FUN14 domain containing 2 pseudogene 3 Neighboring gene RNA, 5S ribosomal pseudogene 222

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27258, FLJ37625, FLJ45012, FLJ90837, KIAA2023, MGC134886

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity EXP
Inferred from Experiment
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase SHPRH
Names
2610103K11Rik
RING-type E3 ubiquitin transferase SHPRH
SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
SNF2, histone-linker, PHD and RING finger domain-containing helicase
NP_001036148.2
NP_001357256.1
NP_001357257.1
NP_775105.1
XP_006715502.1
XP_006715506.1
XP_011534021.1
XP_011534024.1
XP_016866180.1
XP_016866181.1
XP_016866182.1
XP_016866185.1
XP_024302161.1
XP_024302162.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042683.3NP_001036148.2  E3 ubiquitin-protein ligase SHPRH isoform a

    See identical proteins and their annotated locations for NP_001036148.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AA315737, AK126959, AL451145, AY161136, AY163808, BC117686, BX648322
    Consensus CDS
    CCDS43513.2
    UniProtKB/Swiss-Prot
    Q149N8
    UniProtKB/TrEMBL
    B3KX98
    Related
    ENSP00000275233.7, ENST00000275233.12
    Conserved Domains (7) summary
    COG0553
    Location:15111678
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00162
    Location:14321482
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15547
    Location:660706
    PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
    pfam00176
    Location:716987
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:15131622
    Helicase_C; Helicase conserved C-terminal domain
    pfam00538
    Location:440511
    Linker_histone; linker histone H1 and H5 family
    pfam13424
    Location:10201104
    TPR_12; Tetratricopeptide repeat
  2. NM_001370327.1NP_001357256.1  E3 ubiquitin-protein ligase SHPRH isoform a

    Status: VALIDATED

    Source sequence(s)
    AL356599, AL451145
  3. NM_001370328.1NP_001357257.1  E3 ubiquitin-protein ligase SHPRH isoform c

    Status: VALIDATED

    Source sequence(s)
    AL356599, AL451145
  4. NM_173082.3NP_775105.1  E3 ubiquitin-protein ligase SHPRH isoform b

    See identical proteins and their annotated locations for NP_775105.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses three alternate splice sites in the coding region, one of which results in a frameshift, compared to variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AA315737, AY161136, AY163808, BX648322
    Consensus CDS
    CCDS47496.1
    UniProtKB/Swiss-Prot
    Q149N8
    Related
    ENSP00000412797.2, ENST00000438092.6
    Conserved Domains (7) summary
    COG0553
    Location:15151652
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00162
    Location:14361486
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15547
    Location:660706
    PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
    pfam00176
    Location:716987
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:15171626
    Helicase_C; Helicase conserved C-terminal domain
    pfam00538
    Location:440511
    Linker_histone; linker histone H1 and H5 family
    pfam13424
    Location:10291113
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    145857838..145964358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715439.4XP_006715502.1  E3 ubiquitin-protein ligase SHPRH isoform X2

    See identical proteins and their annotated locations for XP_006715502.1

    Conserved Domains (7) summary
    COG0553
    Location:15111648
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00162
    Location:14321482
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15547
    Location:660706
    PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
    pfam00176
    Location:716987
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:15131622
    Helicase_C; Helicase conserved C-terminal domain
    pfam00538
    Location:440511
    Linker_histone; linker histone H1 and H5 family
    pfam13424
    Location:10201104
    TPR_12; Tetratricopeptide repeat
  2. XM_006715443.4XP_006715506.1  E3 ubiquitin-protein ligase SHPRH isoform X6

    Conserved Domains (5) summary
    cd00162
    Location:14321482
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15547
    Location:660706
    PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
    pfam00176
    Location:716987
    SNF2_N; SNF2 family N-terminal domain
    pfam00538
    Location:440511
    Linker_histone; linker histone H1 and H5 family
    pfam13424
    Location:10201104
    TPR_12; Tetratricopeptide repeat
  3. XM_017010693.2XP_016866182.1  E3 ubiquitin-protein ligase SHPRH isoform X3

  4. XM_024446394.1XP_024302162.1  E3 ubiquitin-protein ligase SHPRH isoform X8

    Conserved Domains (4) summary
    COG0553
    Location:10301167
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd15547
    Location:179225
    PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
    pfam00176
    Location:236506
    SNF2_N; SNF2 family N-terminal domain
    cd16569
    Location:948998
    RING-HC_SHPRH; RING finger, HC subclass, found in SNF2 histone-linker PHD finger RING finger helicase (SHPRH) and similar proteins
  5. XM_017010696.2XP_016866185.1  E3 ubiquitin-protein ligase SHPRH isoform X8

    Conserved Domains (4) summary
    COG0553
    Location:10301167
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd15547
    Location:179225
    PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
    pfam00176
    Location:236506
    SNF2_N; SNF2 family N-terminal domain
    cd16569
    Location:948998
    RING-HC_SHPRH; RING finger, HC subclass, found in SNF2 histone-linker PHD finger RING finger helicase (SHPRH) and similar proteins
  6. XM_017010691.2XP_016866180.1  E3 ubiquitin-protein ligase SHPRH isoform X1

  7. XM_024446393.1XP_024302161.1  E3 ubiquitin-protein ligase SHPRH isoform X7

    Conserved Domains (6) summary
    COG0553
    Location:11971334
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd15547
    Location:346392
    PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
    pfam00176
    Location:403673
    SNF2_N; SNF2 family N-terminal domain
    pfam00538
    Location:126197
    Linker_histone; linker histone H1 and H5 family
    cd16569
    Location:11151165
    RING-HC_SHPRH; RING finger, HC subclass, found in SNF2 histone-linker PHD finger RING finger helicase (SHPRH) and similar proteins
    cl26465
    Location:5377
    SNF2_N; SNF2 family N-terminal domain
  8. XM_017010692.1XP_016866181.1  E3 ubiquitin-protein ligase SHPRH isoform X1

  9. XM_011535719.3XP_011534021.1  E3 ubiquitin-protein ligase SHPRH isoform X5

    Conserved Domains (7) summary
    COG0553
    Location:15111658
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00162
    Location:14321482
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15547
    Location:660706
    PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
    pfam00176
    Location:716987
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:15131622
    Helicase_C; Helicase conserved C-terminal domain
    pfam00538
    Location:440511
    Linker_histone; linker histone H1 and H5 family
    pfam13424
    Location:10201104
    TPR_12; Tetratricopeptide repeat
  10. XM_011535722.3XP_011534024.1  E3 ubiquitin-protein ligase SHPRH isoform X9

    Conserved Domains (3) summary
    COG0553
    Location:24389
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd15547
    Location:660706
    PHD_SHPRH; PHD finger found in E3 ubiquitin-protein ligase SHPRH
    pfam00538
    Location:440511
    Linker_histone; linker histone H1 and H5 family

RNA

  1. XR_942391.3 RNA Sequence

  2. XR_942393.3 RNA Sequence

  3. XR_942392.3 RNA Sequence

  4. XR_942390.3 RNA Sequence

  5. XR_002956273.1 RNA Sequence

  6. XR_245512.4 RNA Sequence

  7. XR_001743308.2 RNA Sequence

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