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    TES testin LIM domain protein [ Homo sapiens (human) ]

    Gene ID: 26136, updated on 7-Apr-2024

    Summary

    Official Symbol
    TESprovided by HGNC
    Official Full Name
    testin LIM domain proteinprovided by HGNC
    Primary source
    HGNC:HGNC:14620
    See related
    Ensembl:ENSG00000135269 MIM:606085; AllianceGenome:HGNC:14620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TESS; TESS-2
    Summary
    Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a common fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Aug 2023]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 42.6), thyroid (RPKM 41.1) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TES in Genome Data Viewer
    Location:
    7q31.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (116210539..116258783)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (117525529..117573770)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (115850593..115898837)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724407 Neighboring gene VISTA enhancer hs1798 Neighboring gene transcription factor EC Neighboring gene Sharpr-MPRA regulatory region 6568 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:115807196-115807710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:115825203-115826194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:115826195-115827184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18555 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:115850475-115850737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26529 Neighboring gene uncharacterized LOC124901730 Neighboring gene uncharacterized LOC102724434 Neighboring gene uncharacterized LOC105375463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26531 Neighboring gene Sharpr-MPRA regulatory region 1934 Neighboring gene uncharacterized LOC124900233

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC1146, DKFZp586B2022

    General protein information

    Preferred Names
    testin
    Names
    testis derived transcript (3 LIM domains)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015641.4NP_056456.1  testin isoform 1

      See identical proteins and their annotated locations for NP_056456.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform.
      Source sequence(s)
      AF245356, DC341259
      Consensus CDS
      CCDS5763.1
      UniProtKB/Swiss-Prot
      A4D0U6, Q9GZQ1, Q9HAJ9, Q9UGI8
      UniProtKB/TrEMBL
      A4D0U5, B2RDR4
      Related
      ENSP00000350937.4, ENST00000358204.9
      Conserved Domains (4) summary
      cd09413
      Location:236293
      LIM1_Testin; The first LIM domain of Testin
      cd09416
      Location:299354
      LIM2_Testin; The second LIM domain of Testin
      cd09419
      Location:361419
      LIM3_Testin; The third LIM domain of Testin
      cd09829
      Location:109196
      PET_testin; The PET domain of Testin
    2. NM_152829.3NP_690042.1  testin isoform 2

      See identical proteins and their annotated locations for NP_690042.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' UTR and uses a downstream start codon, compared to variant 1. Thus isoform 2 is nine amino acids shorter than isoform 1.
      Source sequence(s)
      AF245357, AK310995
      Consensus CDS
      CCDS5764.1
      UniProtKB/TrEMBL
      B2RDR4
      Related
      ENSP00000377121.2, ENST00000393481.6
      Conserved Domains (4) summary
      cd09413
      Location:227284
      LIM1_Testin; The first LIM domain of Testin
      cd09416
      Location:290345
      LIM2_Testin; The second LIM domain of Testin
      cd09419
      Location:352410
      LIM3_Testin; The third LIM domain of Testin
      cd09829
      Location:100187
      PET_testin; The PET domain of Testin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      116210539..116258783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      117525529..117573770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)