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    HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 [ Homo sapiens (human) ]

    Gene ID: 26091, updated on 3-Apr-2024

    Summary

    Official Symbol
    HERC4provided by HGNC
    Official Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase 4provided by HGNC
    Primary source
    HGNC:HGNC:24521
    See related
    Ensembl:ENSG00000148634 MIM:609248; AllianceGenome:HGNC:24521
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 8.1), adrenal (RPKM 7.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HERC4 in Genome Data Viewer
    Location:
    10q21.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (67921905..68075283, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (68790646..68944156, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (69681662..69835040, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene SIRT1 promoter region Neighboring gene Sharpr-MPRA regulatory region 7890 Neighboring gene ribosomal protein L12 pseudogene 8 Neighboring gene sirtuin 1 Neighboring gene RPS3A pseudogene 38 Neighboring gene RNA, 7SL, cytoplasmic 220, pseudogene Neighboring gene POU class 5 homeobox 1 pseudogene 5 Neighboring gene MPRA-validated peak985 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2417 Neighboring gene uncharacterized LOC124902442 Neighboring gene myopalladin Neighboring gene uncharacterized LOC107984240 Neighboring gene RN7SK pseudogene 202

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of HECT and RLD domain containing E3 ubiquitin protein ligase 4 (HERC4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1593, DKFZp564G092

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    probable E3 ubiquitin-protein ligase HERC4
    Names
    HECT domain and RCC1-like domain-containing protein 4
    HECT-type E3 ubiquitin transferase HERC4
    hect domain and RLD 4
    NP_001265114.1
    NP_001265115.1
    NP_001265116.1
    NP_056416.2
    NP_071362.1
    XP_011537894.1
    XP_011537895.1
    XP_011537899.1
    XP_016871530.1
    XP_024303695.1
    XP_024303696.1
    XP_024303698.1
    XP_047280946.1
    XP_047280947.1
    XP_047280948.1
    XP_047280949.1
    XP_047280951.1
    XP_047280952.1
    XP_047280953.1
    XP_047280954.1
    XP_047280955.1
    XP_047280956.1
    XP_047280957.1
    XP_047280958.1
    XP_054221433.1
    XP_054221434.1
    XP_054221435.1
    XP_054221436.1
    XP_054221437.1
    XP_054221438.1
    XP_054221439.1
    XP_054221440.1
    XP_054221441.1
    XP_054221442.1
    XP_054221443.1
    XP_054221444.1
    XP_054221445.1
    XP_054221446.1
    XP_054221447.1
    XP_054221448.1
    XP_054221449.1
    XP_054221450.1
    XP_054221451.1
    XP_054221452.1
    XP_054221453.1
    XP_054221454.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278185.2NP_001265114.1  probable E3 ubiquitin-protein ligase HERC4 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AY650032, AY650033, BC018114
      Consensus CDS
      CCDS60541.1
      UniProtKB/TrEMBL
      A8K9U4
      Related
      ENSP00000416504.2, ENST00000412272.6
      Conserved Domains (3) summary
      smart00119
      Location:735976
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:709977
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:208257
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    2. NM_001278186.2NP_001265115.1  probable E3 ubiquitin-protein ligase HERC4 isoform d

      See identical proteins and their annotated locations for NP_001265115.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons compared to variant 1, and one causes a frameshift. These differences cause translation initiation at a downstream AUG and result in an isoform (d) with a shorter and distinct N-terminus and lacking an alternate internal segment, compared to isoform 1.
      Source sequence(s)
      AY650032, BC018114
      UniProtKB/Swiss-Prot
      Q5GLZ8
      Conserved Domains (3) summary
      smart00119
      Location:472791
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:446792
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:553
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    3. NM_001278187.2NP_001265116.1  probable E3 ubiquitin-protein ligase HERC4 isoform e

      See identical proteins and their annotated locations for NP_001265116.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 3'-most exon in place of most of the rest of the transcript compared to variant 1. The resulting isoform (e) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC024258, AY650034, BX101651
      Consensus CDS
      CCDS60542.1
      UniProtKB/Swiss-Prot
      Q5GLZ8
      Related
      ENSP00000422383.1, ENST00000492996.6
      Conserved Domains (1) summary
      COG5184
      Location:269
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    4. NM_015601.4NP_056416.2  probable E3 ubiquitin-protein ligase HERC4 isoform b

      See identical proteins and their annotated locations for NP_056416.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC018114, BC039600, DB459623
      Consensus CDS
      CCDS7274.1
      UniProtKB/TrEMBL
      A8K9U4
      Related
      ENSP00000362804.4, ENST00000373700.9
      Conserved Domains (2) summary
      cd00078
      Location:7011047
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl27697
      Location:2344
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    5. NM_022079.3NP_071362.1  probable E3 ubiquitin-protein ligase HERC4 isoform a

      See identical proteins and their annotated locations for NP_071362.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AY221963, BC015043, BC018114
      Consensus CDS
      CCDS41533.1
      UniProtKB/Swiss-Prot
      Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
      UniProtKB/TrEMBL
      A8K9U4
      Related
      ENSP00000378624.3, ENST00000395198.7
      Conserved Domains (2) summary
      cd00078
      Location:7091055
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl27697
      Location:2344
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      67921905..68075283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424999.1XP_047280955.1  probable E3 ubiquitin-protein ligase HERC4 isoform X11

    2. XM_017016041.3XP_016871530.1  probable E3 ubiquitin-protein ligase HERC4 isoform X10

      UniProtKB/TrEMBL
      A8K9U4
    3. XM_047424998.1XP_047280954.1  probable E3 ubiquitin-protein ligase HERC4 isoform X9

    4. XM_011539597.4XP_011537899.1  probable E3 ubiquitin-protein ligase HERC4 isoform X8

      UniProtKB/TrEMBL
      A8K9U4
      Conserved Domains (3) summary
      smart00119
      Location:638957
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:612958
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:232281
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    5. XM_011539593.4XP_011537895.1  probable E3 ubiquitin-protein ligase HERC4 isoform X2

      UniProtKB/TrEMBL
      A8K9U4
      Conserved Domains (3) summary
      smart00119
      Location:7511070
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:7251071
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:232281
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    6. XM_011539592.4XP_011537894.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

      UniProtKB/TrEMBL
      A8K9U4
      Conserved Domains (2) summary
      COG5184
      Location:2368
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:7331079
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    7. XM_024447930.2XP_024303698.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

      UniProtKB/Swiss-Prot
      Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
      UniProtKB/TrEMBL
      A8K9U4
      Conserved Domains (2) summary
      cd00078
      Location:7091055
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl27697
      Location:2344
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    8. XM_047424990.1XP_047280946.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    9. XM_047425000.1XP_047280956.1  probable E3 ubiquitin-protein ligase HERC4 isoform X11

    10. XM_047424992.1XP_047280948.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

    11. XM_024447927.2XP_024303695.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

      UniProtKB/TrEMBL
      A8K9U4
      Conserved Domains (2) summary
      COG5184
      Location:2368
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:7331079
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    12. XM_047424993.1XP_047280949.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

    13. XM_047424991.1XP_047280947.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

      UniProtKB/Swiss-Prot
      Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
    14. XM_024447928.2XP_024303696.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

      UniProtKB/TrEMBL
      A8K9U4
      Conserved Domains (2) summary
      COG5184
      Location:2368
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:7331079
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    15. XM_047424997.1XP_047280953.1  probable E3 ubiquitin-protein ligase HERC4 isoform X7

    16. XM_047424996.1XP_047280952.1  probable E3 ubiquitin-protein ligase HERC4 isoform X6

    17. XM_047424995.1XP_047280951.1  probable E3 ubiquitin-protein ligase HERC4 isoform X5

      Related
      ENSP00000277817.6, ENST00000277817.10
    18. XM_047425001.1XP_047280957.1  probable E3 ubiquitin-protein ligase HERC4 isoform X12

    19. XM_047425002.1XP_047280958.1  probable E3 ubiquitin-protein ligase HERC4 isoform X13

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      68790646..68944156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365464.1XP_054221439.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

      UniProtKB/Swiss-Prot
      Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
    2. XM_054365476.1XP_054221451.1  probable E3 ubiquitin-protein ligase HERC4 isoform X11

    3. XM_054365459.1XP_054221434.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    4. XM_054365466.1XP_054221441.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

      UniProtKB/Swiss-Prot
      Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
    5. XM_054365460.1XP_054221435.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    6. XM_054365475.1XP_054221450.1  probable E3 ubiquitin-protein ligase HERC4 isoform X11

    7. XM_054365474.1XP_054221449.1  probable E3 ubiquitin-protein ligase HERC4 isoform X10

    8. XM_054365473.1XP_054221448.1  probable E3 ubiquitin-protein ligase HERC4 isoform X9

    9. XM_054365472.1XP_054221447.1  probable E3 ubiquitin-protein ligase HERC4 isoform X8

    10. XM_054365463.1XP_054221438.1  probable E3 ubiquitin-protein ligase HERC4 isoform X2

    11. XM_054365458.1XP_054221433.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    12. XM_054365461.1XP_054221436.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    13. XM_054365462.1XP_054221437.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    14. XM_054365477.1XP_054221452.1  probable E3 ubiquitin-protein ligase HERC4 isoform X11

    15. XM_054365465.1XP_054221440.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

      UniProtKB/Swiss-Prot
      Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
    16. XM_054365467.1XP_054221442.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

    17. XM_054365468.1XP_054221443.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

    18. XM_054365471.1XP_054221446.1  probable E3 ubiquitin-protein ligase HERC4 isoform X7

    19. XM_054365470.1XP_054221445.1  probable E3 ubiquitin-protein ligase HERC4 isoform X6

    20. XM_054365469.1XP_054221444.1  probable E3 ubiquitin-protein ligase HERC4 isoform X5

    21. XM_054365478.1XP_054221453.1  probable E3 ubiquitin-protein ligase HERC4 isoform X12

    22. XM_054365479.1XP_054221454.1  probable E3 ubiquitin-protein ligase HERC4 isoform X13

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001017972.1: Suppressed sequence

      Description
      NM_001017972.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.