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    Tnf tumor necrosis factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24835, updated on 2-May-2024

    Summary

    Symbol
    Tnfprovided by RGD
    Full Name
    tumor necrosis factorprovided by RGD
    Primary source
    RGD:3876
    See related
    Ensembl:ENSRNOG00000070745 AllianceGenome:RGD:3876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tnfa; RATTNF; TNF-alpha
    Summary
    Enables tumor necrosis factor receptor binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of macromolecule metabolic process; and positive regulation of neuron death. Located in several cellular components, including external side of plasma membrane; extracellular space; and neuronal cell body. Used to study several diseases, including cerebrovascular disease (multiple); liver disease (multiple); peptic esophagitis; perinatal necrotizing enterocolitis; and periventricular leukomalacia. Biomarker of several diseases, including brain disease (multiple); congestive heart failure (multiple); inflammatory bowel disease (multiple); lung disease (multiple); and non-alcoholic fatty liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 30.7), Spleen (RPKM 26.5) and 9 other tissues See more
    Orthologs
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    Try the new Transcript table

    Genomic context

    See Tnf in Genome Data Viewer
    Location:
    20p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3626685..3629303)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3622011..3624629)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5189382..5192000, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit G2 Neighboring gene NFKB inhibitor like 1 Neighboring gene lymphotoxin alpha Neighboring gene lymphotoxin beta Neighboring gene leukocyte specific transcript 1 Neighboring gene natural cytotoxicity triggering receptor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC124630

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables death receptor agonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tumor necrosis factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tumor necrosis factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tumor necrosis factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tumor necrosis factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amyloid-beta IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to molecule of bacterial origin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to type II interferon IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chronic inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of mechanical stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic digestive tract development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within humoral immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte migration involved in inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in macrophage activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in necroptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within necroptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in necroptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in necroptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of L-glutamate import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of amyloid-beta clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of bile acid secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of branching involved in lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glucose import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidative phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein-containing complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of I-kappaB phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of action potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of amide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood microparticle formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of chronic inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of estradiol secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of fever generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fractalkine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hair follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hepatocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of hepatocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-18 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of positive regulation of interleukin-33 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte adhesion to arterial endothelial cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of synoviocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of translational initiation by iron ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vitamin D biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of biological quality IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of multicellular organismal process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to 3,3',5-triiodo-L-thyronine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to Gram-negative bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to L-glutamate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to fructose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to gold nanoparticle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to isolation stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to macrophage colony-stimulating factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle contraction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in toll-like receptor 3 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor
    Names
    cachectin
    tumor necrosis factor (TNF superfamily, member 2)
    tumor necrosis factor ligand superfamily member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012675.3NP_036807.1  tumor necrosis factor

      See identical proteins and their annotated locations for NP_036807.1

      Status: VALIDATED

      Source sequence(s)
      BX883046
      UniProtKB/Swiss-Prot
      P16599, Q6EE11, Q9JI26, Q9JI27
      UniProtKB/TrEMBL
      A6KTW8, E7DB74
      Related
      ENSRNOP00000001110.3, ENSRNOT00000001110.6
      Conserved Domains (1) summary
      pfam00229
      Location:105235
      TNF; TNF(tumor Necrosis Factor) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3626685..3629303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)