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Tnf tumor necrosis factor [ Mus musculus (house mouse) ]

Gene ID: 21926, updated on 29-Dec-2020

Summary

Official Symbol
Tnfprovided by MGI
Official Full Name
tumor necrosis factorprovided by MGI
Primary source
MGI:MGI:104798
See related
Ensembl:ENSMUSG00000024401
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DI; Tn; DIF; TNF-; Tnfa; Tnfs; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha
Summary
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression
Broad expression in spleen adult (RPKM 4.1), thymus adult (RPKM 3.0) and 16 other tissues See more
Orthologs
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Genomic context

See Tnf in Genome Data Viewer
Location:
17 B1; 17 18.59 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35418343..35420983, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35199367..35202007, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (35336335..35338941, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene leukocyte specific transcript 1 Neighboring gene microRNA 6973a Neighboring gene lymphotoxin B Neighboring gene microRNA 6974 Neighboring gene lymphotoxin A Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC151434

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
tumor necrosis factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tumor necrosis factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
tumor necrosis factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
tumor necrosis factor receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
activation of MAPKKK activity ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cell activation ISO
Inferred from Sequence Orthology
more info
 
cellular extravasation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
cellular response to nicotine ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
chronic inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to Gram-positive bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
detection of mechanical stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
epithelial cell proliferation involved in salivary gland morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix organization IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
humoral immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte activation involved in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
microglial cell activation IDA
Inferred from Direct Assay
more info
PubMed 
microglial cell activation TAS
Traceable Author Statement
more info
PubMed 
multicellular organism development IMP
Inferred from Mutant Phenotype
more info
PubMed 
necroptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
necroptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of L-glutamate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
negative regulation of alkaline phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of amyloid-beta clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of bile acid secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of branching involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glucose import IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
negative regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of myosin-light-chain-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of production of miRNAs involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein-containing complex disassembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular wound healing ISO
Inferred from Sequence Orthology
more info
 
negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of action potential ISO
Inferred from Sequence Orthology
more info
 
positive regulation of amyloid-beta formation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood microparticle formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcidiol 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chronic inflammatory response to antigenic stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of fever generation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of humoral immune response mediated by circulating immunoglobulin IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-gamma production IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-18 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-33 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of leukocyte adhesion to arterial endothelial cell ISO
Inferred from Sequence Orthology
more info
 
positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neutrophil activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitrogen compound metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of oxidative stress-induced neuron death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein-containing complex disassembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of superoxide dismutase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synoviocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of translational initiation by iron IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vitamin D biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of branching involved in salivary gland morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
regulation of immunoglobulin production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
response to virus ISO
Inferred from Sequence Orthology
more info
 
sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tumor necrosis factor
Names
cachectin
tumor necrosis factor ligand 1f
tumor necrosis factor ligand superfamily member 2
tumor necrosis factor-alpha

NCBI Reference Sequences (RefSeq)

NEW Try the new Data Table view

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278601.1NP_001265530.1  tumor necrosis factor isoform 2

    See identical proteins and their annotated locations for NP_001265530.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    BY167004, CR974444
    Consensus CDS
    CCDS70801.1
    UniProtKB/Swiss-Prot
    P06804
    UniProtKB/TrEMBL
    A0A0R4J210
    Related
    ENSMUSP00000126122.1, ENSMUST00000167924.1
    Conserved Domains (1) summary
    pfam00229
    Location:89219
    TNF; TNF(Tumour Necrosis Factor) family
  2. NM_013693.3NP_038721.1  tumor necrosis factor isoform 1

    See identical proteins and their annotated locations for NP_038721.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK153319, AK153800, CR974444
    Consensus CDS
    CCDS28691.1
    UniProtKB/Swiss-Prot
    P06804
    UniProtKB/TrEMBL
    Q3U593
    Related
    ENSMUSP00000025263.8, ENSMUST00000025263.14
    Conserved Domains (1) summary
    pfam00229
    Location:105235
    TNF; TNF(Tumour Necrosis Factor) family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35418343..35420983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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