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Tnf tumor necrosis factor [ Mus musculus (house mouse) ]

Gene ID: 21926, updated on 1-Oct-2024

Summary

Official Symbol
Tnfprovided by MGI
Official Full Name
tumor necrosis factorprovided by MGI
Primary source
MGI:MGI:104798
See related
Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha
Summary
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression
Broad expression in spleen adult (RPKM 4.1), thymus adult (RPKM 3.0) and 16 other tissues See more
Orthologs
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Genomic context

See Tnf in Genome Data Viewer
Location:
17 B1; 17 18.59 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35418343..35420983, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35199367..35202007, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11796 Neighboring gene leukocyte specific transcript 1 Neighboring gene microRNA 6973a Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:35337508-35337695 Neighboring gene lymphotoxin B Neighboring gene microRNA 6974 Neighboring gene lymphotoxin A Neighboring gene STARR-positive B cell enhancer ABC_E11642 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1 Neighboring gene STARR-positive B cell enhancer ABC_E5601 Neighboring gene STARR-positive B cell enhancer ABC_E7528 Neighboring gene STARR-positive B cell enhancer ABC_E1942 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC151434

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables death receptor agonist activity IDA
Inferred from Direct Assay
more info
PubMed 
enables death receptor agonist activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tumor necrosis factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antiviral innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular extravasation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nicotine IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nicotine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to type II interferon IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chronic inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in chronic inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to Gram-positive bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of mechanical stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic digestive tract development IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within humoral immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in inflammatory response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inflammatory response to wounding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte migration involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte tethering or rolling IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microglial cell activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_positive_effect microglial cell activation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within necroptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in necroptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in necroptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of D-glucose import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of D-glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of L-glutamate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of L-glutamate import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of alkaline phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of amyloid-beta clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bile acid secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of bile acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of branching involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of branching involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine production involved in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of insulin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of negative regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular wound healing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of vascular wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of amide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of amyloid-beta formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of blood microparticle formation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood microparticle formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcidiol 1-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of calcidiol 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cellular metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of chronic inflammatory response to antigenic stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of fever generation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fractalkine production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fractalkine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hepatocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-18 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-18 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-33 production IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of interleukin-33 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte adhesion to arterial endothelial cell IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of leukocyte adhesion to arterial endothelial cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil activation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neutrophil activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of podosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synoviocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of synoviocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of translational initiation by iron IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vitamin D biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vitamin D biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of establishment of endothelial barrier IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of immunoglobulin production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to 3,3',5-triiodo-L-thyronine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in response to L-glutamate IEA
Inferred from Electronic Annotation
more info
 
involved_in response to L-glutamate ISO
Inferred from Sequence Orthology
more info
 
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to fructose IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
involved_in response to gold nanoparticle IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to isolation stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to macrophage colony-stimulating factor IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in sequestering of triglyceride IEA
Inferred from Electronic Annotation
more info
 
involved_in sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 3 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of type II interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vasodilation IEA
Inferred from Electronic Annotation
more info
 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tumor necrosis factor
Names
cachectin
tumor necrosis factor ligand 1f
tumor necrosis factor ligand superfamily member 2
tumor necrosis factor-alpha

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278601.1NP_001265530.1  tumor necrosis factor isoform 2

    See identical proteins and their annotated locations for NP_001265530.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    BY167004, CR974444
    Consensus CDS
    CCDS70801.1
    UniProtKB/TrEMBL
    A0A0R4J210, Q3U4I6
    Related
    ENSMUSP00000126122.2, ENSMUST00000167924.2
    Conserved Domains (1) summary
    pfam00229
    Location:89219
    TNF; TNF(Tumour Necrosis Factor) family
  2. NM_013693.3NP_038721.1  tumor necrosis factor isoform 1

    See identical proteins and their annotated locations for NP_038721.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK153319, AK153800, CR974444
    Consensus CDS
    CCDS28691.1
    UniProtKB/Swiss-Prot
    O35853, P06804, Q62326, Q91VF3
    UniProtKB/TrEMBL
    Q3U4I6, Q3U593
    Related
    ENSMUSP00000025263.9, ENSMUST00000025263.15
    Conserved Domains (1) summary
    pfam00229
    Location:105235
    TNF; TNF(Tumour Necrosis Factor) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35418343..35420983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)