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    COMMD3 COMM domain containing 3 [ Homo sapiens (human) ]

    Gene ID: 23412, updated on 7-Apr-2024

    Summary

    Official Symbol
    COMMD3provided by HGNC
    Official Full Name
    COMM domain containing 3provided by HGNC
    Primary source
    HGNC:HGNC:23332
    See related
    Ensembl:ENSG00000148444 MIM:616700; AllianceGenome:HGNC:23332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BUP; C10orf8
    Summary
    Predicted to be involved in sodium ion transport. Predicted to be located in extracellular region and ficolin-1-rich granule lumen. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart (RPKM 26.0), appendix (RPKM 25.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See COMMD3 in Genome Data Viewer
    Location:
    10p12.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (22316388..22320306)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (22335422..22339340)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (22605317..22609235)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376447 Neighboring gene uncharacterized LOC100130992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:22542487-22543183 Neighboring gene ribosomal protein L31 pseudogene 45 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:22568695-22569196 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:22569197-22569696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3129 Neighboring gene COMMD3-BMI1 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2207 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2208 Neighboring gene BMI1 proto-oncogene, polycomb ring finger Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:22629212-22629998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:22634454-22635270 Neighboring gene sperm associated antigen 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3131 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:22697232-22697772 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:22697773-22698311

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough COMMD3-BMI1

    Readthrough gene: COMMD3-BMI1, Included gene: BMI1

    Clone Names

    • FLJ45471, DKFZp686K0399

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    COMM domain-containing protein 3
    Names
    protein Bup

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012071.4NP_036203.1  COMM domain-containing protein 3

      See identical proteins and their annotated locations for NP_036203.1

      Status: VALIDATED

      Source sequence(s)
      AF201948, BF695081
      Consensus CDS
      CCDS7137.1
      UniProtKB/Swiss-Prot
      D3DRU7, Q5T8Y9, Q9UBI1
      UniProtKB/TrEMBL
      H0Y4W0
      Related
      ENSP00000366032.3, ENST00000376836.8
      Conserved Domains (1) summary
      cd04751
      Location:98194
      Commd3; COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      22316388..22320306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      22335422..22339340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)