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COMMD3-BMI1 COMMD3-BMI1 readthrough [ Homo sapiens (human) ]

Gene ID: 100532731, updated on 23-Nov-2021

Summary

Official Symbol
COMMD3-BMI1provided by HGNC
Official Full Name
COMMD3-BMI1 readthroughprovided by HGNC
Primary source
HGNC:HGNC:48326
See related
Ensembl:ENSG00000269897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BMI1; PCGF4; RNF51
Summary
This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in testis (RPKM 24.5), endometrium (RPKM 22.5) and 25 other tissues See more
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Genomic context

See COMMD3-BMI1 in Genome Data Viewer
Location:
10p12.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (22316388..22331484)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (22605317..22620413)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376447 Neighboring gene uncharacterized LOC100130992 Neighboring gene ribosomal protein L31 pseudogene 45 Neighboring gene COMM domain containing 3 Neighboring gene BMI1 proto-oncogene, polycomb ring finger Neighboring gene sperm associated antigen 6 Neighboring gene uncharacterized LOC105376448

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434I153

General protein information

Preferred Names
COMMD3-BMI1 read-through protein
Names
Polycomb complex protein BMI-1
Polycomb group RING finger protein 4
RING finger protein 51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204062.2NP_001190991.1  COMMD3-BMI1 read-through protein

    Status: VALIDATED

    Source sequence(s)
    AK313235, AL158211
    UniProtKB/Swiss-Prot
    P35226
    UniProtKB/TrEMBL
    R4GMX3
    Related
    ENSP00000473391.1, ENST00000602390.5
    Conserved Domains (3) summary
    pfam00097
    Location:161199
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam07258
    Location:20125
    HCaRG; HCaRG protein
    pfam16207
    Location:291369
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    22316388..22331484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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