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    Lmtk2 lemur tyrosine kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 231876, updated on 5-Sep-2021

    Summary

    Official Symbol
    Lmtk2provided by MGI
    Official Full Name
    lemur tyrosine kinase 2provided by MGI
    Primary source
    MGI:MGI:3036247
    See related
    Ensembl:ENSMUSG00000038970
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KP; cp; BRE; KPI; AATY; BREK; KPI2; cprk; KPI-2; aatyk2; 2900041G10Rik; A330101P12Rik
    Expression
    Ubiquitous expression in cortex adult (RPKM 17.2), frontal lobe adult (RPKM 15.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Lmtk2 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (144037179..144125026)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144100361..144188208)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (144861305..144949073)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54312 Neighboring gene oncomodulin Neighboring gene elongation factor 1-gamma pseudogene Neighboring gene basic helix-loop-helix family, member a15 Neighboring gene tectonin beta-propeller repeat containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin VI binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within nervous system development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transferrin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase LMTK2
    Names
    apoptosis-associated tyrosine kinase 2
    brain-enriched kinase
    NP_001074578.1
    XP_006504888.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081109.2NP_001074578.1  serine/threonine-protein kinase LMTK2 precursor

      See identical proteins and their annotated locations for NP_001074578.1

      Status: VALIDATED

      Source sequence(s)
      AC121845
      Consensus CDS
      CCDS39376.1
      UniProtKB/Swiss-Prot
      Q3TYD6
      Related
      ENSMUSP00000048238.8, ENSMUST00000041804.8
      Conserved Domains (2) summary
      cd05086
      Location:138408
      PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2
      pfam07714
      Location:136406
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      144037179..144125026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504825.5XP_006504888.1  serine/threonine-protein kinase LMTK2 isoform X1

      Conserved Domains (1) summary
      cd05086
      Location:137407
      PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2
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