Lmtk2 lemur tyrosine kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lmtk2provided by MGI
Official Full Name: lemur tyrosine kinase 2provided by MGI
Primary source: MGI:MGI:3036247
See related: Ensembl:ENSMUSG00000038970 AllianceGenome:MGI:3036247
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BREK; KPI2; cprk; KPI-2; aatyk2; 2900041G10Rik; A330101P12Rik
Summary: Predicted to enable myosin VI binding activity; protein phosphatase inhibitor activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including endosomal transport; protein phosphorylation; and transferrin transport. Predicted to act upstream of or within axon guidance and neurotrophin TRK receptor signaling pathway. Predicted to be located in several cellular components, including endosome; growth cone; and neuronal cell body. Is expressed in brain; olfactory cortex marginal layer; and pancreas. Orthologous to human LMTK2 (lemur tyrosine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 17.2), frontal lobe adult (RPKM 15.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 82.85 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (144037179..144125026)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (144100361..144188208)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LMTK2 overexpression alleviated oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and oxidative damage by enhancing Nrf2/antioxidant response element antioxidant signaling via modulation of GSK-3beta phosphorylation.
Title: Overexpression of lemur tyrosine kinase-2 protects neurons from oxygen-glucose deprivation/reoxygenation-induced injury through reinforcement of Nrf2 signaling by modulating GSK-3β phosphorylation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Mit416 (e-PCR), detects polymorphism
- UniSTS:130568

A004H27 (e-PCR)
- UniSTS:63599

Lmtk2 (e-PCR), detects polymorphism
- UniSTS:507033

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables myosin VI binding	IEA Inferred from Electronic Annotation more info
enables myosin VI binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in early endosome to late endosome transport	IEA Inferred from Electronic Annotation more info
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	IEA Inferred from Electronic Annotation more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in receptor recycling	IEA Inferred from Electronic Annotation more info
involved_in receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in transferrin transport	IEA Inferred from Electronic Annotation more info
involved_in transferrin transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase LMTK2

Names: apoptosis-associated tyrosine kinase 2; brain-enriched kinase

NP_001074578.1

EC 2.7.11.1

XP_006504888.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081109.2 → NP_001074578.1 serine/threonine-protein kinase LMTK2

See identical proteins and their annotated locations for NP_001074578.1

Status: VALIDATED

Source sequence(s)

AC121845

Consensus CDS

CCDS39376.1

UniProtKB/Swiss-Prot

A6BLY9, Q3TYD6, Q6PDK6, Q6ZPY9, Q8CA34

Related

ENSMUSP00000048238.8, ENSMUST00000041804.8

Conserved Domains (2) summary

cd05086
Location:138 → 408

PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2

pfam07714
Location:136 → 406

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

144037179..144125026

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504825.5 → XP_006504888.1 serine/threonine-protein kinase LMTK2 isoform X1

Conserved Domains (1) summary

cd05086
Location:137 → 407

PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2