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LMTK2 lemur tyrosine kinase 2 [ Homo sapiens (human) ]

Gene ID: 22853, updated on 24-Nov-2020

Summary

Official Symbol
LMTK2provided by HGNC
Official Full Name
lemur tyrosine kinase 2provided by HGNC
Primary source
HGNC:HGNC:17880
See related
Ensembl:ENSG00000164715 MIM:610989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BREK; KPI2; LMR2; cprk; KPI-2; hBREK; AATYK2; PPP1R100
Summary
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in brain (RPKM 11.9), colon (RPKM 7.7) and 25 other tissues See more
Orthologs

Genomic context

See LMTK2 in Genome Data Viewer
Location:
7q21.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (98106862..98209638)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (97736197..97838945)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 478, pseudogene Neighboring gene oncomodulin 2 Neighboring gene basic helix-loop-helix family member a15 Neighboring gene tectonin beta-propeller repeat containing 1 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 1 Neighboring gene brain protein I3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
GeneReviews: Not available
Multiple newly identified loci associated with prostate cancer susceptibility.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46659, KIAA1079

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
myosin VI binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
NOT transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
transferrin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase LMTK2
Names
CDK5/p35-regulated kinase
apoptosis-associated tyrosine kinase 2
brain-enriched kinase
cyclin-dependent kinase 5/p35-regulated kinase
kinase/phosphatase/inhibitor 2
protein phosphatase 1, regulatory subunit 100
serine/threonine-protein kinase KPI-2
NP_055731.2
XP_011514283.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013375.1 RefSeqGene

    Range
    4978..107754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014916.4NP_055731.2  serine/threonine-protein kinase LMTK2 precursor

    See identical proteins and their annotated locations for NP_055731.2

    Status: REVIEWED

    Source sequence(s)
    AC073101, AC091654, AY130988, BC146773, BE049530
    Consensus CDS
    CCDS5654.1
    UniProtKB/Swiss-Prot
    Q8IWU2
    Related
    ENSP00000297293.5, ENST00000297293.6
    Conserved Domains (2) summary
    cd05086
    Location:139409
    PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2
    pfam07714
    Location:137407
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    98106862..98209638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515981.3XP_011514283.1  serine/threonine-protein kinase LMTK2 isoform X1

    Conserved Domains (2) summary
    cd05086
    Location:137407
    PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2
    pfam07714
    Location:135405
    Pkinase_Tyr; Protein tyrosine kinase
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