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    CEP68 centrosomal protein 68 [ Homo sapiens (human) ]

    Gene ID: 23177, updated on 17-Jun-2024

    Summary

    Official Symbol
    CEP68provided by HGNC
    Official Full Name
    centrosomal protein 68provided by HGNC
    Primary source
    HGNC:HGNC:29076
    See related
    Ensembl:ENSG00000011523 MIM:616889; AllianceGenome:HGNC:29076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA0582
    Summary
    Enables protein domain specific binding activity and protein kinase binding activity. Involved in centriole-centriole cohesion and protein localization to organelle. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 8.3), ovary (RPKM 8.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CEP68 in Genome Data Viewer
    Location:
    2p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (65056416..65087004)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (65066038..65096632)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (65283550..65314138)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 548, pseudogene Neighboring gene solute carrier family 1 member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15923 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:65258211-65259074 Neighboring gene long intergenic non-protein coding RNA 2576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15924 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:65277603-65277775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11573 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:65288315-65288816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:65294702-65295470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:65295471-65296237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:65297006-65297772 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:65304333-65305043 Neighboring gene RAB1A, member RAS oncogene family Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:65354445-65354984 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:65356508-65357022 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:65357023-65357536 Neighboring gene small nucleolar RNA SNORA74 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:65404421-65404957 Neighboring gene MPRA-validated peak3732 silencer Neighboring gene uncharacterized LOC124907779 Neighboring gene VDAC2 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of centrosomal protein 68kDa (CEP68) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25920, FLJ36750

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in centriole-centriole cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to organelle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    centrosomal protein of 68 kDa
    Names
    centrosomal protein 68kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319100.2NP_001306029.1  centrosomal protein of 68 kDa isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC007318, AC007386, AK299373, CA398160
      Consensus CDS
      CCDS1880.2
      UniProtKB/Swiss-Prot
      B4DRQ1, D6W5F1, D6W5F2, O60326, Q76N32, Q9BQ18, Q9UDM9
      UniProtKB/TrEMBL
      A0A994J534
      Related
      ENSP00000515601.1, ENST00000703983.1
      Conserved Domains (1) summary
      PHA03247
      Location:286443
      PHA03247; large tegument protein UL36; Provisional
    2. NM_001319101.2NP_001306030.1  centrosomal protein of 68 kDa isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB011154, AC007318, AC007386, BC004873, CA398160
      Consensus CDS
      CCDS82457.1
      UniProtKB/TrEMBL
      A0A994J770
      Related
      ENSP00000260569.4, ENST00000260569.4
      Conserved Domains (1) summary
      PHA03247
      Location:286443
      PHA03247; large tegument protein UL36; Provisional
    3. NM_001410838.1NP_001397767.1  centrosomal protein of 68 kDa isoform c

      Status: VALIDATED

      Source sequence(s)
      AC007318, AC007386, AC084278
      Consensus CDS
      CCDS92772.1
      UniProtKB/TrEMBL
      A0A994J407, A0A994J4E5
      Related
      ENSP00000515890.1, ENST00000704388.1
    4. NM_015147.3NP_055962.2  centrosomal protein of 68 kDa isoform a

      See identical proteins and their annotated locations for NP_055962.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AB011154, AC007318, CA398160
      Consensus CDS
      CCDS1880.2
      UniProtKB/Swiss-Prot
      B4DRQ1, D6W5F1, D6W5F2, O60326, Q76N32, Q9BQ18, Q9UDM9
      UniProtKB/TrEMBL
      A0A994J534
      Related
      ENSP00000367229.2, ENST00000377990.7
      Conserved Domains (1) summary
      PHA03247
      Location:286443
      PHA03247; large tegument protein UL36; Provisional

    RNA

    1. NR_134966.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB011154, AC007318, AC007386, AK299373, AK304110, CA398160
      Related
      ENST00000703915.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      65056416..65087004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      65066038..65096632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)