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    Mavs mitochondrial antiviral signaling protein [ Mus musculus (house mouse) ]

    Gene ID: 228607, updated on 6-Nov-2018

    Summary

    Official Symbol
    Mavsprovided by MGI
    Official Full Name
    mitochondrial antiviral signaling proteinprovided by MGI
    Primary source
    MGI:MGI:2444773
    See related
    Ensembl:ENSMUSG00000037523 Vega:OTTMUSG00000016041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Visa; IPS-1; cardif; D430028G21Rik
    Expression
    Ubiquitous expression in liver adult (RPKM 50.6), kidney adult (RPKM 46.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See Mavs in Genome Data Viewer
    Location:
    2; 2 F1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (131234063..131248025)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (131059874..131073761)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 25B Neighboring gene adaptor-related protein 5 complex, sigma 1 subunit Neighboring gene pantothenate kinase 2 Neighboring gene microRNA 103-2 Neighboring gene ring finger protein 24 Neighboring gene small nuclear ribonucleoprotein E, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem (from REACTOME)
      Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25836

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    CARD domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    RIG-I signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of IP-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine (C-C motif) ligand 5 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-alpha secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-beta secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myeloid dendritic cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of type I interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitochondrial antiviral-signaling protein
    Names
    CARD adapter inducing interferon beta
    IFN-beta promoter stimulator-1
    interferon beta promoter stimulator protein 1
    mitochondrial anti-viral signaling protein
    virus-induced signaling adapter

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206382.1NP_001193311.1  mitochondrial antiviral-signaling protein isoform 2

      See identical proteins and their annotated locations for NP_001193311.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK153748, AL808128
      UniProtKB/TrEMBL
      Q3U5B1
    2. NM_001206383.1NP_001193312.1  mitochondrial antiviral-signaling protein isoform 2

      See identical proteins and their annotated locations for NP_001193312.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL808128
      UniProtKB/TrEMBL
      Q3U5B1
    3. NM_001206385.1NP_001193314.1  mitochondrial antiviral-signaling protein isoform 1

      See identical proteins and their annotated locations for NP_001193314.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK028421, AK153748, AL808128
      Consensus CDS
      CCDS16760.1
      UniProtKB/Swiss-Prot
      Q8VCF0
      UniProtKB/TrEMBL
      Q3U5B1
      Related
      ENSMUSP00000038339.5, OTTMUSP00000017159, ENSMUST00000041362.11, OTTMUST00000038266
      Conserved Domains (1) summary
      cd08811
      Location:393
      CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1
    4. NM_144888.2NP_659137.1  mitochondrial antiviral-signaling protein isoform 1

      See identical proteins and their annotated locations for NP_659137.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AL808128
      Consensus CDS
      CCDS16760.1
      UniProtKB/Swiss-Prot
      Q8VCF0
      Related
      ENSMUSP00000105828.2, OTTMUSP00000017160, ENSMUST00000110199.2, OTTMUST00000038268
      Conserved Domains (1) summary
      cd08811
      Location:393
      CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      131234063..131248025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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