Format

Send to:

Choose Destination
    • Showing Current items.

    Mavs mitochondrial antiviral signaling protein [ Mus musculus (house mouse) ]

    Gene ID: 228607, updated on 7-Sep-2021

    Summary

    Official Symbol
    Mavsprovided by MGI
    Official Full Name
    mitochondrial antiviral signaling proteinprovided by MGI
    Primary source
    MGI:MGI:2444773
    See related
    Ensembl:ENSMUSG00000037523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IP; Visa; IPS-1; cardif; D430028G21Rik
    Expression
    Ubiquitous expression in liver adult (RPKM 50.6), kidney adult (RPKM 46.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mavs in Genome Data Viewer
    Location:
    2; 2 F1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131075445..131089945)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131234063..131248025)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (131059874..131073761)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cell division cycle 25B Neighboring gene adaptor-related protein 5 complex, sigma 1 subunit Neighboring gene pantothenate kinase 2 Neighboring gene microRNA 103-2 Neighboring gene ring finger protein 24 Neighboring gene small nuclear ribonucleoprotein E, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25836

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CARD domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RIG-I signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of IP-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine (C-C motif) ligand 5 production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myeloid dendritic cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of type I interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitochondrial antiviral-signaling protein
    Names
    CARD adapter inducing interferon beta
    IFN-beta promoter stimulator-1
    interferon beta promoter stimulator protein 1
    mitochondrial anti-viral signaling protein
    virus-induced signaling adapter

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206382.1NP_001193311.1  mitochondrial antiviral-signaling protein isoform 2

      See identical proteins and their annotated locations for NP_001193311.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK153748, AL808128
      UniProtKB/TrEMBL
      Q3U5B1
    2. NM_001206383.1NP_001193312.1  mitochondrial antiviral-signaling protein isoform 2

      See identical proteins and their annotated locations for NP_001193312.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL808128
      UniProtKB/TrEMBL
      Q3U5B1
    3. NM_001206385.1NP_001193314.1  mitochondrial antiviral-signaling protein isoform 1

      See identical proteins and their annotated locations for NP_001193314.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK028421, AK153748, AL808128
      Consensus CDS
      CCDS16760.1
      UniProtKB/Swiss-Prot
      Q8VCF0
      UniProtKB/TrEMBL
      Q3U5B1
      Related
      ENSMUSP00000038339.6, ENSMUST00000041362.12
      Conserved Domains (1) summary
      cd08811
      Location:393
      CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1
    4. NM_144888.2NP_659137.1  mitochondrial antiviral-signaling protein isoform 1

      See identical proteins and their annotated locations for NP_659137.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AL808128
      Consensus CDS
      CCDS16760.1
      UniProtKB/Swiss-Prot
      Q8VCF0
      Related
      ENSMUSP00000105828.3, ENSMUST00000110199.3
      Conserved Domains (1) summary
      cd08811
      Location:393
      CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      131075445..131089945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161358.1XP_036017251.1  mitochondrial antiviral-signaling protein isoform X1

    2. XM_036161359.1XP_036017252.1  mitochondrial antiviral-signaling protein isoform X1

    Support Center