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MAVS mitochondrial antiviral signaling protein [ Homo sapiens (human) ]

Gene ID: 57506, updated on 24-Nov-2020

Summary

Official Symbol
MAVSprovided by HGNC
Official Full Name
mitochondrial antiviral signaling proteinprovided by HGNC
Primary source
HGNC:HGNC:29233
See related
Ensembl:ENSG00000088888 MIM:609676
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPS1; VISA; IPS-1; CARDIF
Summary
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral innate immunity. [provided by RefSeq, Jul 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in colon (RPKM 9.9), fat (RPKM 9.0) and 25 other tissues See more
Orthologs

Genomic context

See MAVS in Genome Data Viewer
Location:
20p13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (3846834..3876118)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3827446..3856770)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 5 subunit sigma 1 Neighboring gene NFE2L2 motif-containing MPRA enhancer 155/156 Neighboring gene PANK2 antisense RNA 1 Neighboring gene pantothenate kinase 2 Neighboring gene microRNA 103a-2 Neighboring gene microRNA 103b-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef (NL4-3) degrades (leads to degradation of) MAVS PubMed
nef HIV-1 Nef (NL4-3) blocks MAVS (IPS-1) induced antiviral signalling (IFN release) of host cell (CEM) PubMed
Vpu vpu HIV-1 Vpu (NL4-3) degrades (leads to degradation of) MAVS PubMed
vpu HIV-1 Vpu (NL4-3) blocks MAVS (IPS-1) induced antiviral signalling (IFN release) of host cell (CEM) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: AP5S1

Homology

Clone Names

  • MGC3260, FLJ27482, FLJ31698, FLJ35386, FLJ38051, FLJ41962, KIAA1271, DKFZp547C224, DKFZp666M015

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CARD domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
 
negative regulation of type I interferon production TAS
Traceable Author Statement
more info
 
negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
positive regulation of IP-10 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chemokine (C-C motif) ligand 5 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-alpha production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of myeloid dendritic cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of peroxisome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial antiviral-signaling protein
Names
CARD adapter inducing interferon beta
CARD adaptor inducing IFN-beta
IFN-B promoter stimulator 1
interferon beta promoter stimulator protein 1
putative NF-kappa-B-activating protein 031N
virus-induced signaling adaptor
virus-induced-signaling adapter

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030028.1 RefSeqGene

    Range
    5036..34320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206491.2NP_001193420.1  mitochondrial antiviral-signaling protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL109804, AL353194
    Consensus CDS
    CCDS56176.1
    UniProtKB/Swiss-Prot
    Q7Z434
    Related
    ENSP00000413749.2, ENST00000416600.6
    Conserved Domains (1) summary
    PRK07003
    Location:92265
    PRK07003; DNA polymerase III subunits gamma and tau; Validated
  2. NM_001385663.1NP_001372592.1  mitochondrial antiviral-signaling protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL109804, AL353194
  3. NM_020746.5NP_065797.2  mitochondrial antiviral-signaling protein isoform 1

    See identical proteins and their annotated locations for NP_065797.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL353194, BC044952, DB219666, DQ167126
    Consensus CDS
    CCDS33437.1
    UniProtKB/Swiss-Prot
    Q7Z434
    Related
    ENSP00000401980.2, ENST00000428216.4
    Conserved Domains (1) summary
    cd08811
    Location:393
    CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1

RNA

  1. NR_037921.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL353194, DB219666, EF467324

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    3846834..3876118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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