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    DOLK dolichol kinase [ Homo sapiens (human) ]

    Gene ID: 22845, updated on 8-Jul-2021

    Summary

    Official Symbol
    DOLKprovided by HGNC
    Official Full Name
    dolichol kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:23406
    See related
    Ensembl:ENSG00000175283 MIM:610746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DK; DK1; CDG1M; SEC59; TMEM15
    Summary
    The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
    Orthologs
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    Genomic context

    See DOLK in Genome Data Viewer
    Location:
    9q34.11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128945530..128947603, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131707809..131709882, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 8 VRAC subunit A Neighboring gene uncharacterized LOC101929291 Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene nucleoporin 188 Neighboring gene uncharacterized LOC101929314 Neighboring gene SH3 domain containing GRB2 like, endophilin B2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1094

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dolichol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables dolichol kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dolichol kinase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in dolichyl diphosphate biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in dolichyl monophosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in dolichyl monophosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dolichol kinase
    Names
    SEC59 homolog
    dolichol kinase 1
    transmembrane protein 15
    NP_055723.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017009.1 RefSeqGene

      Range
      5001..7204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_744

    mRNA and Protein(s)

    1. NM_014908.4NP_055723.1  dolichol kinase

      See identical proteins and their annotated locations for NP_055723.1

      Status: REVIEWED

      Source sequence(s)
      BC035556, BF056649
      Consensus CDS
      CCDS6915.1
      UniProtKB/Swiss-Prot
      Q9UPQ8
      UniProtKB/TrEMBL
      A0A0S2Z597
      Related
      ENSP00000361667.3, ENST00000372586.4
      Conserved Domains (1) summary
      cl21502
      Location:337524
      CTP_transf_1; Cytidylyltransferase family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      128945530..128947603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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